Dietary strategies in non‐alcoholic fatty liver disease patients: From evidence to daily clinical practice, a systematic review

Hadefi, Alia; Arvanitakis, Marianna; Trépo, Eric; Zelber‐Sagi, Shira

doi:10.1002/ueg2.12443

Cited by 5 publications

(3 citation statements)

References 126 publications

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“…Moreover, our results indicate that this rising trend is evident across all ethnic groups, women, individuals with obesity, non-hypertensive individuals, and subgroups with hyperlipidemia. This signifies the urgency of strengthening the management and intervention strategies for MASLD patients and high-risk individuals [22,23]. However, there is currently a lack of effective drugs to treat MASLD and exercise and diet modification are still the mainstream ways to prevent and treat MASLD.…”

Section: Discussionmentioning

confidence: 99%

Trends in Oxidative Balance Score and Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in the United States: National Health and Nutrition Examination Survey 2001 to 2018

Tan,

Wu,

Meng

et al. 2023

Nutrients

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Background: Most studies have primarily focused on assessing the association between diet or exercise patterns and metabolic dysfunction-associated steatotic liver disease (MASLD). This study adopted a more comprehensive approach by introducing the oxidative balance score (OBS) to evaluate the combined effects of diet and lifestyle on the body’s antioxidant ability. Our main objective was to investigate the association between OBS and the burden of MASLD in the United States. Methods: Participants with complete information from 2001 to 2018 were included. In the absence of other definite liver injury factors, the United States fatty liver index (us-FLI) ≥ 30 was used as the diagnostic criterion for MASLD. We first calculated the weighted prevalence for each cycle and stratified it according to demographic and metabolic-related disease characteristics. Subsequently, weighted multiple logistic regression was used to evaluate the relationship between OBS and MASLD. In addition, we explored the body’s inflammatory state and the level of insulin resistance (IR) in mediating OBS and MASLD. Results: From 2001 to 2018, the prevalence of MASLD in the U.S. population as a whole increased from 29.76% to 36.04%, and the rate was higher in people with metabolic-related diseases. Notably, OBS exhibited a negative correlation with MASLD. Participants in the highest tertile of OBS had a significantly lower prevalence of MASLD compared to those in the lowest tertile [OR: 0.72, 95%CI: (0.57, 0.92), p < 0.001]. Moreover, a high OBS is associated with a lower inflammatory state and level of IR. The body’s inflammatory state and IR level mediated the association between OBS and MASLD by 5.2% and 39.7%, respectively (both p < 0.001). Conclusions: In this study, we observed an increasing prevalence of MASLD over the years. A higher OBS was associated with a lower risk of MASLD, especially when OBS ≥ 25. The body’s inflammatory state and IR level mediate the association between OBS and MASLD, but the mechanism needs to be further investigated.

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Section: Discussionmentioning

confidence: 99%

Trends in Oxidative Balance Score and Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in the United States: National Health and Nutrition Examination Survey 2001 to 2018

Tan,

Wu,

Meng

et al. 2023

Nutrients

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“…Several prospective studies have provided evidence for the independent, beneficial association of healthy dietary composition with NAFLD regression ( 27 , 28 , 44 , 45 ). Notably, the Mediterranean diet’s emphases on reducing sugars and refined carbohydrates, saturated fat, red and processed meats, and ultra-processed foods are all relevant to NAFLD pathogenesis and even HCC incidence ( 46 ). Saturated fat has been shown to have a negative effect on liver fat accumulation in several clinical trials ( 35 ).…”

Section: Dietary Quality Not Quantity: Nutrient Composition Is Keymentioning

confidence: 99%

Practical Lifestyle Management of Nonalcoholic Fatty Liver Disease for Busy Clinicians

Zelber-Sagi,

Moore

2024

Diabetes Spectrum

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Weight loss achieved through a combination of healthy eating patterns that encompass the principles of the Mediterranean diet and regular physical activity is the most evidence-based treatment for nonalcoholic fatty liver disease. Although other types of diets have demonstrated efficacy in liver fat reduction, the Mediterranean diet confers additional cardiometabolic benefits. Macronutrient composition, food choices, and timing of eating can be tailored to individual preferences, culture, and financial circumstances; however, recommended healthy eating patterns are characterized by minimally processed or unprocessed foods (vegetables, legumes, nuts and seeds, fruits, whole grains, and unprocessed meats and fish) that are low in sugar, refined carbohydrates, and saturated fat and high in fiber, polyphenols, vitamins, minerals, and healthy fats. Physical activity can independently improve steatosis, prevent fibrosis and cirrhosis, and reduce mortality.

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“…In recent years, several therapeutic options have been proposed for the treatment of MASLD. However, no approved drugs for these patients are available yet, and clinical strategies are mainly based on diet, physical activity, lifestyle modification and control of the associated metabolic disorders [23,24]. Moreover, the use of probiotics, prebiotics, supplements or natural substances are also able to modulate the gut microbiota and to regulate the gut-liver axis [25][26][27].…”

Section: Nutraceutical Approaches In Masld: Curcuminmentioning

confidence: 99%

Molecular Mechanisms of Curcumin in the Pathogenesis of Metabolic Dysfunction Associated Steatotic Liver Disease

Guariglia,

Saba,

Rosso

et al. 2023

Nutrients

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Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial condition characterized by insulin resistance, oxidative stress, chronic low-grade inflammation, and sometimes fibrosis. To date, no effective pharmacological therapy has been approved for the treatment of metabolic-associated steatohepatitis (MASH), the progressive form of MASLD. Recently, numerous in vitro and in vivo studies have described the efficacy of nutraceutical compounds in the diet has been tested. Among them, curcumin is the most widely used polyphenol in the diet showing potent anti-inflammatory and antifibrotic activities. This review aims to summarize the most important basic studies (in vitro and animal models studies), describing the molecular mechanisms by which curcumin acts in the context of MASLD, providing the rationale for its effective translational use in humans.

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Dietary strategies in non‐alcoholic fatty liver disease patients: From evidence to daily clinical practice, a systematic review

Cited by 5 publications

References 126 publications

Trends in Oxidative Balance Score and Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in the United States: National Health and Nutrition Examination Survey 2001 to 2018

Trends in Oxidative Balance Score and Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in the United States: National Health and Nutrition Examination Survey 2001 to 2018

Practical Lifestyle Management of Nonalcoholic Fatty Liver Disease for Busy Clinicians

Molecular Mechanisms of Curcumin in the Pathogenesis of Metabolic Dysfunction Associated Steatotic Liver Disease

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