Dietary soybean phosphatidylcholines lower lipidemia: mechanisms at the levels of intestine, endothelial cell, and hepato-biliary axis

Mastellone, Isabelle; Polichetti, Elisabeth; Grès, Sandra; Maisonneuve, Caroline; Domingo, N.; Marin, Valérie; Lorec, Anne-Marie; Farnarier, Catherine; Portugal, Henri; Kaplanski, Gilles; Chanussot, F.

doi:10.1016/s0955-2863(00)00115-7

Cited by 37 publications

(25 citation statements)

References 34 publications

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“…8,9 In the present work, soy lecithin supplementation did alter immune cell functions as indicated by the changes in macrophage phagocytic capacity and lymphocyte proliferation. The increased macrophage phagocytic capacity in non-diabetic Wistar rats strongly suggests that macrophages incorporated the dietary phosphatidylcholine at a high rate, as previously demonstrated in vitro.…”

Section: Discussionsupporting

confidence: 47%

“…This compound is very active in biological systems exerting important effects upon lipid absorption 1 and secretion of biliary lipids. [2][3][4][5][6][7] In animal feeding experiments, it was demonstrated that lecithin reduces cholesterolemia 5,8,9 and food intake, 10 both conditions associated with life-style diseases, such as diabetes. 11,12 Indeed, it has been shown that dietary lecithin supplementation improves blood lipid profile in hyperlipidemic patients.…”

Section: Introductionmentioning

confidence: 99%

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Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan‐induced diabetic rats

Miranda

Batista

Grando

et al. 2008

Cell Biochemistry & Function

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Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture of lymphocytes has been reported to alter their function. If phosphatidylcholine changes lymphocyte functions in vitro as previously shown, then it could also affect immune cells in vivo. In the present study, the effect of dietary soy lecithin on macrophage phagocytic capacity and on lymphocyte number in response to concanavalin A (ConA) stimulation was investigated in non-diabetic and alloxan-induced diabetic rats. Supplementation was carried out daily with 2 g kg(-1) b.w. lecithin during 7 days. After that, blood was drawn from fasting rats and peritoneal macrophages and mesenteric lymph node lymphocytes were collected to determine the phospholipid content. Plasma triacylglycerol (TAG), total and HDL cholesterol and glucose levels were also determined. Lymphocytes were stimulated by ConA. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) dye reduction method and flow cytometry were employed to evaluate lymphocyte metabolism and cell number, respectively. Soy lecithin supplementation significantly increased both macrophage phagocytic capacity (+29%) in non-diabetic rats and the lymphocyte number in diabetic rats (+92%). It is unlikely that plasma lipid levels indirectly affect immune cells, since plasma cholesterol, TAG, or phospholipid content was not modified by lecithin supplementation. In conclusion, lymphocyte and macrophage function were altered by lecithin supplementation, indicating an immunomodulatory effect of phosphatidylcholine.

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Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan‐induced diabetic rats

Miranda

Batista

Grando

et al. 2008

Cell Biochemistry & Function

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“…The components of the nanocarrier system for the functional food applications were carefully selected based on loading of the hydrophobic active ingredient, Generally Regarded as Safe (GRAS) status, biocompatibility and some intrinsic therapeutic activities possessed by these materials e.g., Soy lecithin. Soya lecithin is an amphiphilic lipid component of the nanocarrier and has shown numerous benefits like anti-ageing (Ueda et al 2011), anti-stress effect (Hellhammer et al 2004), anti-hypercholesterolemia (Mastellone et al 2000), immunomodulator effect (Miranda et al 2008) etc. Further, addition of lecithin in aqueous food system like fruit juices in the concentration range of 0.1-2 % has been advocated by various researchers (Oke et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications

2015

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The supramolecular nano-assemblies formed by electrostatic interactions of two oppositely charged lipid and polymer have been made and used as nanocarriers for curcumin to address its bioavailability and solubility issues. These curcumin encapsulated nano-supramolecular assemblies were characterized with respect to their size (dynamic light scattering), morphology (TEM, SEM), zeta potential (Laser Doppler Velocimetry), encapsulation efficiency (EE), curcumin loading (CL) etc. Stability of the nano-assemblies was assessed at different storage times as a function of varying pH and temperature. The physicochemical characterization of nano-assemblies was performed using Fourier Transform Infra Red Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC). The in-vitro antioxidant lipid peroxidation (TBARS), radical scavenging (DPPH, NO, H 2 O 2 , reducing power) activity assays of powdered curcumin and nanoencapsulated curcumin were performed. It was found that nano-encapsulated curcumin were roughly spherical in shape, presented high positive zeta potential (>30 mV), monodisperse (polydispersity index <0.3), amorphous in nature, stable in the pH range of 2-6 and have enhanced antioxidant potency in comparison to crystalline curcumin in aqueous media. In conclusion, the curcumin encapsulated nanocarriers system has great potential as functional food ingredient of natural origin.

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“…Growing evidence indicates that dietary PLs, especially phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS), have beneficial effects compared with dietary TGs. For example, dietary PC, PE and PS have been reported to have lipid-lowering effects and improve brain function, respectively [5][6][7][8][9][10] . Despite the fact that the use of PC and PS for nutritional and therapeutical purposes has increased in recent years, reports examining the physiological functions of dietary Phosphatidylinositol (PI) are scarce.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Phosphatidylinositol on Cholesterol Metabolism in Zucker (fa/fa) Rats

et al. 2009

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Recent studies have shown that dietary phospholipids, especially phosphatidylcholine and phosphatidylserine, have various beneficial biological effects. However, there are not enough data concerning the physiological function of dietary phosphatidylinositol (PI). The metabolic syndrome, a cluster of metabolic abnormalities such as dyslipidemia, diabetes mellitus, and hypertension, is widespread and increasingly prevalent diseases in industrialized countries. In the present study, we evaluated that the effect of dietary PI on cholesterol metabolism in metabolic syndrome model Zucker (fa/fa) rats. For 4 weeks, rats were fed semisynthetic diets containing either 7% soybean oil or 5% soybean oil plus 2% PI. Dietary PI prevented the mild hypercholesterolemia and hepatic cholesterol accumulation in Zucker (fa/fa) rats. These effects were attributable to an increased fecal bile acid excretion and to the tendencies of decreased ACAT1 mRNA level and increased CYP7A1 mRNA level in the liver. Additionally, dietary PI markedly increased microsomal PI content in the liver of Zucker (fa/fa) rats. Our study suggests that dietary PI normalizes cholesterol metabolism through the enhancement of fecal bile acid excretion in the metabolic syndrome model rats.

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Dietary soybean phosphatidylcholines lower lipidemia: mechanisms at the levels of intestine, endothelial cell, and hepato-biliary axis

Cited by 37 publications

References 34 publications

Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan‐induced diabetic rats

Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan‐induced diabetic rats

Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications

Effect of Dietary Phosphatidylinositol on Cholesterol Metabolism in Zucker (fa/fa) Rats

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