Dietary soy protein improves adipose tissue dysfunction by modulating parameters related with oxidative stress in dyslipidemic insulin-resistant rats

Illesca, Paola; Selenscig, Dante; Ferreira, María del Rosario; Giménez, María Sofía; Lombardo, Yolanda B.; D'Alessandro, María Eugenia

doi:10.1016/j.biopha.2017.01.153

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…These findings are in accordance with previous studies that analyzed the individual Cγ effect to reduce the proinflammatory response and insulin resistance in PANC-1 cells, through the modulation of INF-γ expression, cytokines (IL-6, IL-12P70, IL-17A, and IL-27), and ROS levels, as well as an increase in antioxidant molecules [ 20 , 58 ]. Furthermore, animal studies have reported that the intake of soybean proteins directly improves oxidative stress [ 59 , 60 , 61 ]. Even if studies addressing the antioxidant or anti-inflammatory effect of lupanine have not been conducted, some reports have evaluated the effects of different alkaloids showing a gene expression reduction in proinflammatory genes such as TNF-α, IL-6, and IL-1 followed by an increase in antioxidant enzymes due to Nrf2 signaling activation and a decrease in the profibrogenic transcription factor Snail-1 [ 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Combined Gamma Conglutin and Lupanine Treatment Exhibits In Vivo an Enhanced Antidiabetic Effect by Modulating the Liver Gene Expression Profile

et al. 2023

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Previous studies have individually shown the antidiabetic potential of gamma conglutin (Cγ) and lupanine from lupins. Until now, the influence of combining both compounds and the effective dose of the combination have not been assessed. Moreover, the resulting gene expression profile from this novel combination remains to be explored. Therefore, we aimed to evaluate different dose combinations of Cγ and lupanine by the oral glucose tolerance test (OGTT) to identify the higher antidiabetic effect on a T2D rat model. Later, we administered the selected dose combination during a week. Lastly, we evaluated biochemical parameters and liver gene expression profile using DNA microarrays and bioinformatic analysis. We found that the combination of 28 mg/kg BW Cγ + 20 mg/kg BW lupanine significantly reduced glycemia and lipid levels. Moreover, this treatment positively influenced the expression of Pdk4, G6pc, Foxo1, Foxo3, Ppargc1a, Serpine1, Myc, Slc37a4, Irs2, and Igfbp1 genes. The biological processes associated with these genes are oxidative stress, apoptosis regulation, and glucose and fatty-acid homeostasis. For the first time, we report the beneficial in vivo effect of the combination of two functional lupin compounds. Nevertheless, further studies are needed to investigate the pharmacokinetics and pharmacodynamics of the Cγ + lupanine combined treatment.

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Section: Discussionmentioning

confidence: 99%

Combined Gamma Conglutin and Lupanine Treatment Exhibits In Vivo an Enhanced Antidiabetic Effect by Modulating the Liver Gene Expression Profile

et al. 2023

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“…protein has also been reported to inhibit blood pressure [35] and exhibit antioxidant activity [36], whereas soybean isoflavones exhibit anti-cancer effects [37,38] and promote bone formation [39]. Furthermore, intake of miso soup before pregnancy significantly reduces the risk of early preterm birth [40].…”

Section: Plos Onementioning

confidence: 99%

Ingestion of miso regulates immunological robustness in mice

et al. 2022

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In Japan, there is a long history of consumption of miso, a fermented soybean paste, which possesses beneficial effects on human health. However, the mechanism behind these effects is not fully understood. To clarify the effects of miso on immune cells, we evaluated its immunomodulatory activity in mice. Miso did not alter the percentage of B and T cells in the spleen; however, it increased CD69+ B cells, germinal center B cells and regulatory T cells. Anti-DNA immunoglobulin M antibodies, which prevent autoimmune disease, were increased following ingestion of miso. Transcriptome analysis of mouse spleen cells cultured with miso and its raw material revealed that the expression of genes, including interleukin (IL)-10, IL-22 and CD86, was upregulated. Furthermore, intravital imaging of the small intestinal epithelium using a calcium biosensor mouse line indicated that miso induced Ca2+ signaling in a manner similar to that of probiotics. Thus, ingestion of miso strengthened the immune response and tolerance in mice. These results appear to account, at least in part, to the salubrious effects of miso.

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“…It has also been shown that not only Nox, but also mitochondria of adipocytes can be a source of ROS [12] . The state which is similar to MS is developed in rats on diet with a sucrose-rich diet for 4 months [13] . These rats have high levels of MDA, protein carbonyl groups and TNF-α in blood plasma.…”

Section: Oxidative Stress In Metabolic Syndrome Experimental Datamentioning

confidence: 99%

Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?

Maslov

Naryzhnaya

Boshchenko

et al. 2019

Journal of Clinical & Translational Endocrinology

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Metabolic syndrome is accompanied by oxidative stress in animals and humans. The main source of ROS in experimental metabolic syndrome is NADPH oxidase and possibly adipocyte mitochondria. It is now documented that oxidative stress induces insulin resistance of adipocytes and increases secretion of leptin, MCP-1, IL-6, and TNF-α by adipocytes. It was established that oxidative stress induces a decrease in adiponectin production by adipocytes. It has also been shown that obesity itself can induce oxidative stress. Oxidative stress can cause an alteration of intracellular signaling in adipocytes that apparently leads to the formation of insulin resistance of adipocytes. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α also play an important role in the pathogenesis of oxidative stress of adipocytes. Oxidative stress is not only a consequence of metabolic syndrome, but also a reason and a foundational link in the pathogenesis of the metabolic syndrome.

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Dietary soy protein improves adipose tissue dysfunction by modulating parameters related with oxidative stress in dyslipidemic insulin-resistant rats

Cited by 12 publications

References 46 publications

Combined Gamma Conglutin and Lupanine Treatment Exhibits In Vivo an Enhanced Antidiabetic Effect by Modulating the Liver Gene Expression Profile

Combined Gamma Conglutin and Lupanine Treatment Exhibits In Vivo an Enhanced Antidiabetic Effect by Modulating the Liver Gene Expression Profile

Ingestion of miso regulates immunological robustness in mice

Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome?

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