Dietary soy isoflavones during pregnancy suppressed the immune function in male offspring albino rats

Gaffer, Ghada Gamal; Elgawish, Rania Abdelrahman; Abdelrazek, Heba M. A.; Ebaid, Hala M.; Tag, Hend M.

doi:10.1016/j.toxrep.2018.02.002

Cited by 13 publications

(10 citation statements)

References 62 publications

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“…Moreover, the function of NO as an intracellular messenger in chemokine signaling pathways [80] decreased and was manifested by decreasing levels of TNF- α and IL-2 in the soy OVX group to a level comparable to sham ones. These decrements were in accordance with results of Shalaby and Elgawish [81], Azadbakht et al [26], and Gaffer et al [35]. The scavenging effect of soy isoflavones to ROS which was demonstrated by restoration of TAC as well as reduction in MDA could entangle ROS-mediated NF- κ B/TNF- α signaling activation [82].…”

Section: Discussionsupporting

confidence: 88%

“…These effects include antitumor [30], antimenopausal osteoporosis [31] and antidiabetic, antidyslipidemic [32], and anti-inflammatory effects [33] as well as protective effects against coronary heart diseases [34]. In addition, they exert a myriad of immunological [35, 36], metabolic [37], antioxidant power, and hepatoprotective effects in laboratory animal models [9]. Therefore, the current study aimed at investigating the effects of soy isoflavones as HRT on estrogen deprivation-associated metabolic, immunological, and bone health disturbances in OVX female Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

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Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Abdelrazek

Mahmoud

Tag

et al. 2019

Oxidative Medicine and Cellular Longevity

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Hormone replacement therapy (HRT) can alleviate estrogen deficiency symptoms especially during menopause. The present study aimed at investigating the effect of soy isoflavones as HRT on immunological and bone health-related parameters with a special focus on the interactions between immunological status and metabolism. Thirty healthy cyclic female Wistar rats were used in this experiment. Ten females were sham-operated, and 20 females were subjected to ovariectomy. Overiectomized (OVX) female rats were randomly divided into 2 groups: the control group (G1, OVX/casein) was fed a casein-based diet, and the second group (G2, OVX/soy) was fed a high soy isoflavone diet. Both groups were compared to a sham-operated group (G3, sham/casein). Treatments continued for 7 weeks. Feed intake, weight gain, and lymphoid organ relative weights were recorded. Some metabolic, immunological, and bone health-related parameters were measured. Moreover, nitric oxide (NO), malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined. Bone histopathology and immunohistochemistry to estrogen receptor alpha (ERα) were done. Feeding soy to OVX females reduced feed intake, weight gain, relative lymphoid organ weight, and T-lymphocytes transformation. Soy isoflavone administration normalized nearly all metabolic and immunological parameters to a level comparable to the sham group via oxidative stress amelioration and bone ERα promotion. Soy isoflavones seemed to be good HRT in estrogen deprivation which modulated the appetite, weight gain, lipid profile, proinflammation, and bone turnover.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Abdelrazek

Mahmoud

Tag

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Isoflavone compound, with C 6 -C 3 -C 6 as the mother stone, is one of the effective components of many traditional Chinese medicines and has been included into The Chinese Pharmacopoeia [27]. Isoflavone has a variety of activities such as cardiovascular protection [28], anti-tumor [29], osteoporosis prevention [30], nerve protection, neurodegeneration resistance [31], blood sugar reduction [32], and immune system regulation [33]. Its anti-cancer properties are prominent, and it can inhibit the growth and spread of cancer cells, effective to cancer cells only.…”

Section: Analysis Of Compoundsmentioning

confidence: 99%

Identification and Analysis of Secondary Metabolites from CH₃OH/H₂O Extract of Metacordyceps Neogunnii

et al. 2019

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Secondary metabolites are considered to be the major compounds in Cordyceps with anti-tumor, anti-aging and immunity-enhancing effects. The molecular structures of secondary metabolites form the basis for the development and utilization of Cordyceps. Metacordyceps neogunnii is an important Cordyceps resource, but less study has been made on the molecular structure of its secondary metabolites. In this study, gas chromatography-mass spectrometry (GC/MS) and ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) were used to analyze and identify the secondary metabolites from CH3OH/H2O extract of Metacordyceps neogunnii. The results show that a total of 22 compounds were identified by GC-MS, including 2 n-alkanes, 1 isoparaffin, 1 cycloalkane, 6 olefins and 13 esters. The predominant compounds were (E)-ocimene, (E)-β-ocimene, methyl oleate, dioctyl adipate, methyl palmitate and methyl linoleate, obtained by means of GC/MS. Five distince classes of secondary metabolites were speculated: 3 polypeptides, 2 esters, 1 isoflavone, 1 isoindrone and 3 amides, from which 10 compounds were detected using UPLC-Q-TOF/MS. (R)-N-((1-(((9H-fluorene-9-yl) methoxy) carbonyl) pyrrolidine-2-yl) methyl)-N-(2-(6-benzoylamino-9H-purin-9-yl) acetyl) glycine, benzyl (5-(2-((3-(2, 3-dihydrobenzo[b] [1, 4] dioxin-6-yl)-4-carbonyl-4H-chromene-7-yl) oxo) acetylamino) amyl) carbamate, 5, 5’-((propane-2, 2-diyl (4, 1-phenylene)) bis (oxo)) bis (2-(naphthalene-1-yl) isoindoline-1, 3-dione), 1-dodecylazepine-2-one and other compounds were the first detected in Metacordyceps neogunnii.

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“…The left foot of each experimental rat/ group was injected 0.1 mL of 10% (v/v) phytohemagglutinin (PHA) (L 9017, Sigma Aldrich, USA) in PBS. The right foot pad of the same rat was kept as control through inoculation with 0.1 mL of PBS 57,58 . The rats were kept for 24 h, then the thickness of the lateral and dorso-ventral aspects of the left foot pad at the injection point was assessed via manual micrometer.…”

Section: Phytohemagglutinin Injection and Intumesce Indexmentioning

confidence: 99%

The effect of dietary supplementation of Nigella sativa (black seeds) on cell mediated immunological function of male Wistar rats

Mahmoud¹,

Almallah

El-Hak

et al. 2020

Preprint

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This experiment aimed to investigate the effect of dietary Nigella sativa on cell mediated immune response. A total of eighteen male Wistar rats were divided equally into control and black seeds at 30 and 50 g/kg/diet (Sa30 and Sa50), respectively for 30 days. Weight gain, feed intake, feed conversion ratio (FCR), cell mediated immune response was monitored after injection of 0.1 mL of 10% phytohemagglutinin (PHA). Intumesce Index, serum total antioxidant capacity (TAC), Catalase (CAT), Interleukin-12 (IL-12), gamma interferon (γ-IF) and tumor necrosis factor alpha (TNF-α) were determined. Histopathological examination and immunohistochemistry of splenic caspase-3 and CD 8 were done. Nigella sativa significantly (p<0.05) improved weight gain and FCR in Sa30 and Sa50 groups. Significant increase for Intumesce Index in Sa50 group was observed. Total TAC, CAT, IL-12, γ-IF and TNF-αincreased significantly (P<0.05) in Sa30 and Sa50 groups. Histological examination of PHA stimulated foot pads showed more leukocytes infiltration and edema in a dose dependent pattern. Splenic caspase-3 and CD 8 showed significant (P<0.05) decrease and increase, respectively in Sa30 and Sa50 groups. Nigella sativa seeds had immunostimulatory ability through their antioxidant potential, cytokines induction, CD 8 promotion and reducing splenic apoptosis.

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Dietary soy isoflavones during pregnancy suppressed the immune function in male offspring albino rats

Abstract: Graphical abstract

Cited by 13 publications

References 62 publications

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Identification and Analysis of Secondary Metabolites from CH₃OH/H₂O Extract of Metacordyceps Neogunnii

The effect of dietary supplementation of Nigella sativa (black seeds) on cell mediated immunological function of male Wistar rats

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Dietary soy isoflavones during pregnancy suppressed the immune function in male offspring albino rats

Abstract: Graphical abstract

Cited by 13 publications

References 62 publications

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential

Identification and Analysis of Secondary Metabolites from CH3OH/H2O Extract of Metacordyceps Neogunnii

The effect of dietary supplementation of Nigella sativa (black seeds) on cell mediated immunological function of male Wistar rats

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Product

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Identification and Analysis of Secondary Metabolites from CH₃OH/H₂O Extract of Metacordyceps Neogunnii