Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study

Vogiatzoglou, Anna; Smith, A.D.; Nurk, Eha; Berstad, Paula; Drevon, Christian A.; Ueland, Per Magne; Vollset, Stein Emil; Tell, Grethe S.; Refsum, Helga

doi:10.3945/ajcn.2008.26598

Cited by 131 publications

(134 citation statements)

References 45 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…In the Czech Republic reported mean levels of serum vitamin B 12 were comparable to those in other European countries, such as Norway (40) , and above the reference value (150 pmol/l). These findings are consistent with the vitamin B 12 intake results from the present study (Fig.…”

Section: Comparison Of Micronutrient Statusmentioning

confidence: 63%

Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

Novaković

Cavelaars

Bekkering

et al. 2012

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To compare micronutrient intakes and status in Central and Eastern Europe (CEE) with those in other European countries and with reference values. Design: Review of the micronutrient intake/status data from open access and grey literature sources from CEE. Setting: Micronutrients studied were folate, iodine, Fe, vitamin B 12 and Zn (for intake and status) and Ca, Cu, Se, vitamin C and vitamin D (for intake). Intake data were based on validated dietary assessment methods; mean intakes were compared with average nutrient requirements set by the Nordic countries or the US Institute of Medicine. Nutritional status was assessed using the status biomarkers and cut-off levels recommended primarily by the WHO. Subjects: For all population groups in CEE, the mean intake and mean/median status levels were compared between countries and regions: CEE, Scandinavia, Western Europe and Mediterranean. Results: Mean micronutrient intakes of adults in the CEE region were in the same range as those from other European regions, with exception of Ca (lower in CEE). CEE children and adolescents had poorer iodine status, and intakes of Ca, folate and vitamin D were below the reference values. Conclusions: CEE countries are lacking comparable studies on micronutrient intake/ status across all age ranges, especially in children. Available evidence showed no differences in micronutrient intake/status in CEE populations in comparison with other European regions, except for Ca intake in adults and iodine and Fe status in children. The identified knowledge gaps urge further research on micronutrient intake/status of CEE populations to make a basis for evidence-based nutrition policy.

show abstract

Section: Comparison Of Micronutrient Statusmentioning

confidence: 63%

Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

Novaković

Cavelaars

Bekkering

et al. 2012

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…Thus, HO-B12 is a ubiquitous and sometimes predominant form of B12 in food [1]. The daily supply of B12 in a Western omnivorous diet is around 6 µg [3,4], well above the recommended daily allowance (RDA) of 2.4 µg [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

et al. 2017

View full text Add to dashboard Cite

Purpose We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency. Methods Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16), or a placebo (n = 20). Blood at baseline, and each following week, was examined for total cobalamin, holotranscobalamin, methylmalonic acid, and homocysteine. Results The study groups did not differ at baseline and were characterized by [median (range)] serum cobalamin [128 (68-191)

show abstract

“…However, the relationship with intake from meat, poultry or fish is weaker (5) . A Norwegian study showed that plasma vitamin B 12 increases with the amounts of vitamin B 12 provided by dairy products or fish but not with those provided by eggs or meat (6) . Moreover, for a similar intake, plasma concentrations of vitamin B 12 were higher when the vitamin was supplied by dairy products than by fish, suggesting that the bioavailability of the vitamin from dairy products is higher than from the other sources (6) .…”

mentioning

confidence: 99%

“…A Norwegian study showed that plasma vitamin B 12 increases with the amounts of vitamin B 12 provided by dairy products or fish but not with those provided by eggs or meat (6) . Moreover, for a similar intake, plasma concentrations of vitamin B 12 were higher when the vitamin was supplied by dairy products than by fish, suggesting that the bioavailability of the vitamin from dairy products is higher than from the other sources (6) . Indeed, these retrospective studies seem to indicate that vitamin B 12 supplied by dairy products is more available than from other natural sources, although in these studies, intake data were obtained by a FFQ.…”

mentioning

confidence: 99%

Bioavailability of vitamin B₁₂ in cows' milk

2011

View full text Add to dashboard Cite

The natural source of vitamin B 12 in human diets comes from animal products. For example, one glass (250 ml) of milk provides approximately 50 % of the RDA (2·4 mg/d). It was hypothesised that the provision of vitamin B 12 from milk is more efficiently absorbed than the synthetic form used in vitamin supplements. Pigs (n 10) were used as a model for intestinal absorption of vitamin B 12 in humans to compare the net fluxes of vitamin B 12 across the portal-drained viscera (PDV; an indicator of intestinal absorption) after ingestion of meals complemented with conventional and vitamin B 12 -enriched (via injections to cows) milk (raw, pasteurised or microfiltrated) or with equivalent amounts of cyanocobalamin, the synthetic form used in supplements or unsupplemented. Net flux of vitamin B 12 across PDV after the ingestion of milk was positive, though not influenced by milk enrichment (P. 0·3) or technological processes (P¼0·8) and was greater than after ingestion of equivalent amounts of cyanocobalamin (cyanocobalamin v. all milk, P# 0·003). In fact, net fluxes of this vitamin were not different from 0 after either cyanocobalamin or the meal devoid of vitamin B 12 (unsupplemented v. cyanocobalamin, P¼ 0·7). The cumulative PDV fluxes during the 24 h following ingestion of meals complemented with milk varied from 5·5 to 6·8 mg. These values correspond to an efficiency of intestinal absorption of vitamin B 12 from milk varying between 8 and 10 %. Therefore, vitamin B 12 , which is abundant in cows' milk, is also substantially more available than the most commonly used synthetic form of this vitamin.

show abstract

Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study

Abstract: Dietary intake of dairy products and fish are significant contributors to plasma vitamin B-12 and may improve plasma vitamin B-12 status. Vitamin B-12 appears to be more bioavailable from dairy products; guidelines for improving vitamin B-12 status should take this into consideration.

Cited by 131 publications

References 45 publications

Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

Bioavailability of vitamin B₁₂ in cows' milk

Contact Info

Product

Resources

About

Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study

Abstract: Dietary intake of dairy products and fish are significant contributors to plasma vitamin B-12 and may improve plasma vitamin B-12 status. Vitamin B-12 appears to be more bioavailable from dairy products; guidelines for improving vitamin B-12 status should take this into consideration.

Cited by 131 publications

References 45 publications

Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

Bioavailability of vitamin B12 in cows' milk

Contact Info

Product

Resources

About

Bioavailability of vitamin B₁₂ in cows' milk