Dietary sodium acetate improves high-fat diet utilization through promoting differential nutrients metabolism between liver and muscle in Nile tilapia (Oreochromis niloticus)

Regulation of lipid metabolism by gut microbiota in aquatic animals

“…Further analysis revealed that sodium acetate mainly increased lipid catabolism through activation of the hepatic AMPK / pparα pathway, thereby alleviating high‐fat‐diet‐induced hepatic lipid deposition 63,65 . In addition to improving liver lipid metabolism, sodium acetate had no positive effect on muscle lipid metabolism in Nile tilapia 65 . However, dietary sodium acetate significantly elevated the level of crude lipid in zebrafish and decreased the content of triglyceride in serum in Nile tilapia 63,122 .…”

“…SCFAs are also signalling molecules that regulate lipid metabolism. For example, activation of the hepatic AMPK / pparα pathway 63–65 . The influence of SCFAs on lipid metabolism is unclear.…”

“…Bacillus amyloliquefaciens SS1 improved the growth performance but reduced the lipid deposition by increasing the concentration of acetate in Nile tilapia intestines 63 . Only a few studies have dealt with the influence of SCFAs on lipid metabolism in fish 64,65,122 . Dietary sodium acetate supplementation decreased lipid accumulation in liver tissue in Nile tilapia and blunt snout bream ( Megalobrama amblycephala ), 63,65,123 improved the growth performance in Nile tilapia and zebrafish 63,65,122 .…”

“…Only a few studies have dealt with the influence of SCFAs on lipid metabolism in fish 64,65,122 . Dietary sodium acetate supplementation decreased lipid accumulation in liver tissue in Nile tilapia and blunt snout bream ( Megalobrama amblycephala ), 63,65,123 improved the growth performance in Nile tilapia and zebrafish 63,65,122 . Further analysis revealed that sodium acetate mainly increased lipid catabolism through activation of the hepatic AMPK / pparα pathway, thereby alleviating high‐fat‐diet‐induced hepatic lipid deposition 63,65 .…”

“…Dietary sodium acetate supplementation decreased lipid accumulation in liver tissue in Nile tilapia and blunt snout bream ( Megalobrama amblycephala ), 63,65,123 improved the growth performance in Nile tilapia and zebrafish 63,65,122 . Further analysis revealed that sodium acetate mainly increased lipid catabolism through activation of the hepatic AMPK / pparα pathway, thereby alleviating high‐fat‐diet‐induced hepatic lipid deposition 63,65 . In addition to improving liver lipid metabolism, sodium acetate had no positive effect on muscle lipid metabolism in Nile tilapia 65 .…”