Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and Lowers Triglyceride in Rats Fed a High-Fat Diet

Handayani, Dian; Jz, Chen; Meyer, Barbara J.; Huang, Xu‐Feng

doi:10.1155/2011/258051

Cited by 34 publications

(20 citation statements)

References 35 publications

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“…Diet and feed were kept constant during the experimental period in other to rule out any source of variation. Animal studies have shown that mushroom enriched diet have no effect on body weight (Handayani et al, 2011). Whitley et al (2009) reported that a commercial probiotic had no effect on body weight of goats as observed in treated animals in our study.…”

Section: Discussioncontrasting

confidence: 42%

Effect of a Mushroom (Coriolus versicolor) Based Probiotic on Goat Health

Ekwemalor¹,

Asiamah²,

Adjei‐Fremah³

et al. 2016

American Journal of Animal and Veterinary Sciences

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Maintenance of an adequate immune response is essential to goat health. CorPet biomass is a mushroom (Coriolus versicolor) based probiotic used as an immune-stimulant in man, horses and small animals. Fifteen BoerXSpanish goats were used in a crossover design to evaluate the effect of a commercial mushroom based probiotic across two periods on resilience of goats to gastrointestinal parasites in pasture based systems. Following initial screening for infection, goats were assigned to three groups of five (n = 15) individuals. Powdered CorPet was soaked in hot or cold water and sterile filtered. Goats were drenched daily with 10 mL of the hot (treatment I) or cold (treatment II) extract daily for an 8 week period. A control group of five age-matched goats received sterile water (treatment III). Body Weight (BW), Fecal Egg Count (FEC), FAMACHA scores, Packed Cell Volume (PCV) and White Blood Cell Differential counts (WBC) were determined weekly. The concentration of total serum protein, 8 Pro-inflammatory cytokines and Prostaglandin (PGE2) secretion was evaluated using commercial ELISAs for each. Treatment had no effect on BW, FEC, FAMACHA scores, PCV and WBC. Total serum protein concentration (p<0.001) increased. Increased levels of interferon production regulator (IFNr), Rantes and Granulocyte-Colony Stimulating Factor (GCSF) and decreased levels of Granulocyte Macrophage ColonyStimulating Factor (GM-CSF) were observed in treated goats. The concentration of PGE2 decreased in all groups over the study period of 8 weeks. Greater changes were observed in treated goats (65-80%) compared to control (50%). Thus in goats CorPet may modulate innate immunity through differential regulation of the secretion of serum proteins including cytokines and PGE2 to impact goat health.

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Section: Discussioncontrasting

confidence: 42%

Effect of a Mushroom (Coriolus versicolor) Based Probiotic on Goat Health

Ekwemalor¹,

Asiamah²,

Adjei‐Fremah³

et al. 2016

American Journal of Animal and Veterinary Sciences

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“…Using a Shiitake mushroom-enriched diet to lower plasma lipid has been widely reported [1,2,3,4]. More recently, the role of Shiitake mushrooms in preventing body weight gain has been reported but its mechanism was largely unknown [5]. The previous study identified that a Shiitake mushroom-enriched diet in rats fed a high fat diet (HFD) significantly lowered plasma triacylglycerol (TAG) and fat deposition by −55% and −35%, respectively, compared to HFD alone [5].…”

Section: Introductionmentioning

confidence: 99%

A High-Dose Shiitake Mushroom Increases Hepatic Accumulation of Triacylglycerol in Rats Fed a High-Fat Diet: Underlying Mechanism

et al. 2014

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Shiitake mushroom have been shown to have health benefits including lowering plasma lipids and preventing body weight gain. However, their underlying mechanisms are largely unknown. The study aim was to assess the potential underlying mechanism of Shiitake mushrooms in lowering plasma triacylglycerol (TAG) in rats fed a high fat diet (HFD). Forty Wistar rats were divided into control group were given HFD and treatment group were fed HFD, enriched with Shiitake mushroom powder at a low dose (LD-M): 0.7%, medium dose (MD-M): 2%, or high dose (HD-M): 6% (wt:wt) for six weeks. Diets were isocaloric containing ~50% energy from fat. After six weeks’ dietary intervention, the rats were sacrificed, and blood and tissue samples were collected. The HD-M group showed a significantly higher ratio of liver weight to 100 g body weight (p < 0.05), a more severe hepatic steatosis marker, such as hepatocyte ballooning (p < 0.0001), and more liver triacylglycerol content than LD-M and MD-M (p < 0.05). HD-M also showed a significantly decreased ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE) compared to HFD (p < 0.05), however, there were no differences compared to HD-M and MD-M. Our results also showed a positive association between the dosage, liver TAG, and liver ballooning histology. A negative association was found between the mushroom dosage and the ratio of liver PC to PE. This study showed the mechanism of how high-dose Shiitake mushroom (HD-M) prevents obesity by increasing TAG accumulation in the liver, rather than adipose tissue.

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“…Mushroom is an important natural source of medicine and healthy food with high nutrition, low-calorie, high quality proteins, vitamins and minerals (El Enshasy et al, 2013). Dietary supplementation with Shiitake mushrooms in a high-fat diet can prevent body weight gain, fat deposition, and plasma TAG (triacylglycerol) in rats (Handayani et al, 2011).In general, the ability of medicinal mushrooms as immunestimulator is occurred via innate immunity that typically mediated by phagocytic cells. Phagocytic cells interact with pathogen components or ingest invading them that in either case further serve as stimulator for innate and adaptive immunity through cytokines and chemokine secretion (Hetland et al, 2008).…”

mentioning

confidence: 99%

Dietary Supplementation of Mushroom Water Suppresses Fat Accumulation in High Fat Diet Induced-Obese Female Mice and Enhances Immune Cell Development in Non-Obese Mice

Bing

Sophors

et al. 2015

JABC

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Extracted mushroom water showed an ability to suppress the accumulation of body fat in female mice after feeding 5 weeks with high fat diet. Particularly, in parametrial and mesenteric adipose, it significantly reduced 44 and 47% of weight, respectively. In non-obese mice, maturated NK cell (CD11b hi CD27 lo ) population were increased (70.9±3.8% ) in mushroom water fed mice compared to control (61.4±4.3%) and NK cell population were augmented in mushroom fed mice compared to control.Keywords fat accumulation · high fat diet · immune-stimulator · mushroom · natural killer cell · obesity Obesity plays major role as a contributor to some disease such as fatty liver disease, type 2 diabetes and cardiovascular diseases (Zimmet et al., 2001;Kotronen and Yki-Jarvinen, 2008; van Dis et al., 2009). High fat diet (HFD) is one of main factors that contribute to the development of obesity (Buettner et al., 2007;Lee, 2013). Mushroom is an important natural source of medicine and healthy food with high nutrition, low-calorie, high quality proteins, vitamins and minerals (El Enshasy et al., 2013). Dietary supplementation with Shiitake mushrooms in a high-fat diet can prevent body weight gain, fat deposition, and plasma TAG (triacylglycerol) in rats (Handayani et al., 2011).In general, the ability of medicinal mushrooms as immunestimulator is occurred via innate immunity that typically mediated by phagocytic cells. Phagocytic cells interact with pathogen components or ingest invading them that in either case further serve as stimulator for innate and adaptive immunity through cytokines and chemokine secretion (Hetland et al., 2008). Here we investigated the effects of mushroom water in high fat dietinduced obese mice and immune cell modulation in non-obese mice. Mushroom water is effective to suppress fat accumulation in obese female mice. Total 16 male and female C5BL/67 mice, 6-8 weeks of ages, were divided into three groups; Group 1 or control: mice were fed with normal water and low fat diet (18% calories from fat), Group 2 or HFD: mice were fed with normal water and high fat diet (45% calories from fat). Group 3 or HFD-MR: Mice were fed with mushroom water and high fat diet. Mushroom water was produced from submerged Lentinus edodes mycelia and fruit body with Sawdust media by mixing 100 g (Saw dust media) with 1 L of distilled water and the extraction was carried out for 14 days at 25 o C. The residue was removed by centrifugation and the filtration. Mice have free access to water and food. The average amount intake per day of water and food is calculated everyday by measuring the left water in bottles and food weights, respectively. The mushroom concentration is 0.588 mg/mL (as 10 mg in 17 mL/mouse/day).After feeding 5 weeks, final body weight of male mice but not This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in a...

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Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and Lowers Triglyceride in Rats Fed a High-Fat Diet

Cited by 34 publications

References 35 publications

Effect of a Mushroom (<i>Coriolus versicolor</i>) Based Probiotic on Goat Health

Effect of a Mushroom (<i>Coriolus versicolor</i>) Based Probiotic on Goat Health

A High-Dose Shiitake Mushroom Increases Hepatic Accumulation of Triacylglycerol in Rats Fed a High-Fat Diet: Underlying Mechanism

Dietary Supplementation of Mushroom Water Suppresses Fat Accumulation in High Fat Diet Induced-Obese Female Mice and Enhances Immune Cell Development in Non-Obese Mice

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