Dietary<scp>L</scp>-Cysteine Improves the Antioxidative Potential and Lipid Metabolism in Rats Fed a Normal Diet

Lee, Seulki; Han, Kyu‐Ho; Nakamura, Yasuhiko; Kawakami, Sakura; Shimada, Kaoru; Hayakawa, Touru; Onoue, Hirotake; Fukushima, Michihiro

doi:10.1271/bbb.130083

Cited by 30 publications

(32 citation statements)

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“…The GR level in Cys1G rats was similar to the level in CG group rats with no significant (p>0.05) differences identified. Rats treated with L-cysteine supplementation and CG group rats had similar GPx and GST activities with no significant (p>0.05) differences identified similar to a previous study (12). Hepatic catalase levels were similar with no significant (p>0.05) differences identified and hepatic GR, GPx, and GST levels were significantly (p<0.05) decreased in DGalN-injected group rats, compared with CN group rats (Fig.…”

Section: )supporting

confidence: 84%

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Dietary l-cysteine inhibits d-galactosamine-induced acute liver injury in rats

Lee

Han

Yabuki

et al. 2015

Food Sci Biotechnol

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The effects of L-cysteine (1 and 2%) on the antioxidative system were examined in rats with Dgalactosamine (D-GalN)-induced injury. These rats showed increases in serum antioxidative enzyme and hepatic thiobarbituric acid reactive substances (TBARS) activities, with decreased hepatic/serum glutathione (GSH) levels and GSH-related enzyme activities. However, L-cysteine supplementation resulted in a decrease of hepatic TBARS levels, and increased catalase and serum GSH levels. The activities of serum enzymes in rats receiving 2% L-cysteine were significantly (p<0.05) lower than in D-GalN-injected group rats, and similar to levels in control group rats without acute liver injury. In addition, 2% L-cysteine increased the glutathione reductase activity and decreased the serum TBARS level in liver injury group rats. Dietary L-cysteine, especially at a 2% level, exerts a hepatoprotective effect by alteration of the GSH level and antioxidative enzyme activities.

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Section: )supporting

confidence: 84%

“…However, Dilger et al (11) reported that excess dietary L-cysteine causes oxidative stress and mortality in rats. In contrast, a previous study demonstrated that L-cysteine at levels of 1 and 2% in a 4 week diet enhanced the hepatic antioxidant status without any symptoms (12).…”

Section: Introductionmentioning

confidence: 58%

Dietary l-cysteine inhibits d-galactosamine-induced acute liver injury in rats

Lee

Han

Yabuki

et al. 2015

Food Sci Biotechnol

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“…Lee et al. reported that l ‐cysteine effectively reduces triglyceride concentrations in serum and liver in a dose‐dependent manner in rats fed a normal diet . The derivatives of l ‐cysteine also regulate lipid metabolism.…”

Section: Nutritional Use Of L‐cysteinementioning

confidence: 99%

l‐Cysteine metabolism and its nutritional implications

Yin

Ren

Yang

et al. 2015

Molecular Nutrition Food Res

277

188

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L-Cysteine is a nutritionally semiessential amino acid and is present mainly in the form of L-cystine in the extracellular space. With the help of a transport system, extracellular L-cystine crosses the plasma membrane and is reduced to L-cysteine within cells by thioredoxin and reduced glutathione (GSH). Intracellular L-cysteine plays an important role in cellular homeostasis as a precursor for protein synthesis, and for production of GSH, hydrogen sulfide (H(2)S), and taurine. L-Cysteine-dependent synthesis of GSH has been investigated in many pathological conditions, while the pathway for L-cysteine metabolism to form H(2)S has received little attention with regard to prevention and treatment of disease in humans. The main objective of this review is to highlight the metabolic pathways of L-cysteine catabolism to GSH, H(2)S, and taurine, with special emphasis on therapeutic and nutritional use of L-cysteine to improve the health and well-being of animals and humans.

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“…maggots). Thus supplemented mothers may have deposited more fat and / or proteins into their eggs, which may have boosted the ROS scavenging machinery through the enhancement of antioxidant synthesis and / or activity (Dringen et al 1999;Lee et al 2013). Indeed, food-supplemented females tended to lay heavier eggs.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover dietary components with no specific antioxidant properties are used to build important antioxidant molecules (e.g. thiols and enzymes) (Dringen et al 1999;Lee et al 2013). Studies on laboratory and wild animals showed that differences in the protein content of the diet can affect the oxidative status of an individual (Feoli et al 2006;Cohen et al 2009;Beaulieu et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Sex-specific effects of prenatal and postnatal nutritional conditions on the oxidative status of great tit nestlings

Giordano

Tschirren

2014

Oecologia

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The early life period is characterized by fast growth and development, which can lead to high reactive oxygen species (ROS) production. Young animals thus have to balance their investment in growth versus ROS defence, and this balance is likely mediated by resource availability. Consequently resources transferred prenatally by the mother and nutritional conditions experienced shortly after birth may crucially determine the oxidative status of young animals. Here, we experimentally investigated the relative importance of pre-and early postnatal nutritional conditions on the oxidative status of great tit nestlings (Parus major). We show that resources transferred by the mother through the egg and nutritional conditions encountered after hatching affect the oxidative status of nestling in a sexspecific way. Daughters of non-supplemented mothers and daughters which did not receive extra food during the early postnatal period had higher oxidative damage than sons, while no differences between sons and daughters were found when extra food was provided pre-or postnatally. No effect of the food supplementations on growth, fledging mass or tarsus length was observed, indicating that female nestlings maintained their investment in growth at the expense of ROS defence mechanisms when resources were limited. The lower priority of the antioxidant defence system for female nestlings was also evidenced by lower levels of specific antioxidant components. These results highlight the important role of early parental effects in shaping oxidative stress in the offspring, and show that the sensitivity to these parental effects is sex-specific. 2 AbstractThe early life period is characterized by fast growth and development, which can lead to high reactive oxygen species (ROS) production. Young animals thus have to balance their investment in growth versus ROS defence, and this balance is likely mediated by resource availability. Consequently resources transferred prenatally by the mother and nutritional conditions experienced shortly after birth may crucially determine the oxidative status of young animals.Here we experimentally investigated the relative importance of pre-and early postnatal nutritional conditions on the oxidative status of great tit nestlings (Parus major). We show that resources transferred by the mother through the egg and nutritional conditions encountered after hatching affect the oxidative status of nestling in a sex-specific way. Daughters of non-supplemented mothers, and daughters, which did not receive extra food during the early postnatal period had higher oxidative damage than sons, while no differences between sons and daughters were found when extra food was provided pre-or postnatally. No effect of the food supplementations on growth, fledging mass or tarsus length was observed, indicating that female nestlings maintained their investment in growth at the expense of ROS defence mechanisms when resources were limited. The lower priority of the antioxidant defence system for female nestlings wa...

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DietaryL-Cysteine Improves the Antioxidative Potential and Lipid Metabolism in Rats Fed a Normal Diet

Cited by 30 publications

References 44 publications

Dietary l-cysteine inhibits d-galactosamine-induced acute liver injury in rats

Dietary l-cysteine inhibits d-galactosamine-induced acute liver injury in rats

l‐Cysteine metabolism and its nutritional implications

Sex-specific effects of prenatal and postnatal nutritional conditions on the oxidative status of great tit nestlings

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