Dietary Saponin, a Factor Which May Reduce Liver and Serum Cholesterol Levels

Newman, Howard; Kummerow, Fred A.; Scott, H. M.

doi:10.3382/ps.0370042

Cited by 59 publications

(8 citation statements)

References 19 publications

(17 reference statements)

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“…Similar results have been reported for several species of animals ingesting saponins from different plant sources (18)(19)(20)(21)(22). Thus, the data suggest that saponins may be involved in the hypocholesterolemic effects of alfalfa meal in rabbits (23)(24)(25)(26), rats (27), and monkeys (28)(29)(30)(31), although possible additional effects of other components of alfalfa meal, such as fiber, (27) have not been ruled out.…”

Section: Discussionsupporting

confidence: 78%

Cholesterol and bile acid balance in Macaca fascicularis. Effects of alfalfa saponins.

Malinow¹,

Connor²,

McLaughlin³

et al. 1981

J. Clin. Invest.

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Section: Discussionsupporting

confidence: 78%

Cholesterol and bile acid balance in Macaca fascicularis. Effects of alfalfa saponins.

Malinow¹,

Connor²,

McLaughlin³

et al. 1981

J. Clin. Invest.

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“…It has been demonstrated that the mixture of capric and caprylic acids (20 to 100 g/kg) can enhance average daily gain (ADG) without any effects on ADFI for weaning pigs during the first two weeks after supplementation (Cera et al, 1989;Rodas and Maxwell, 1992). Steroidal saponins, as the main active substance of Yucca schidigera extract, (about 10% on a dry matter basis), are reported to reduce blood cholesterol levels of laying hens and humans (Newman et al, 1957;Kim et al, 2003;Cheeke et al, 2006). This effect arises because those saponins are able to bind to cholesterol excreted in bile, thus inhibiting entero-hepatic cholesterol recycling (Cheeke et al, 2006).…”

Section: Discussionmentioning

confidence: 95%

Effect of caprylic acid andYucca schidigeraextract on production performance, egg quality, blood characteristics, and excreta microflora in laying hens

Wang

Kim

2011

British Poultry Science

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1. A total of 240 Hy-line brown laying hens (36-week-old), were used in this 8 week experiment to evaluate the effect of caprylic acid and Yucca schidigera extract (CY) on production performance, egg quality, blood characteristics, and excreta microflora. 2. Layers were divided into 5 dietary treatment groups which consisted of: (1) NC, basal diet; (2) PC, basal diet + 110 mg/kg of tylosin; (3) CY1, basal diet + 30 mg/kg caprylic acid + 30 mg/kg Yucca extract; (4) CY2, basal diet + 60 mg/kg caprylic acid + 60 mg/kg Yucca extract; (5) CY3, basal diet + 120 mg/kg caprylic acid + 120 mg/kg Yucca extract. The Yucca extract contained 12·5% saponins. 3. Egg production was unaffected, whereas egg weights and feed efficiency were linearly improved by the addition of CY. There were no differences in the egg quality parameters throughout the experimental period. Plasma total triglyceride and cholesterol concentration in plasma and egg yolk were decreased as utilisation of CY increased. The Escherichia coli counts were linearly inhibited by the CY treatments when compared with the NC treatment at both the 5 and 8 week stages. No difference was observed on the Lactobacillus population through the whole experimental period. 4. In conclusion, the addition of 120 mg/kg caprylic acid and 120 mg/kg Yucca extract exerted positive effects on egg weight and feed efficiency, decreased the serum and yolk cholesterol concentration and reduced the proliferation of Escherichia coli.

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“…They hypothesized that cholesterol in bile combines with saponin in the gut and in this manner cholesterol is excreted. Newman et al (1958) noted that when both saponin and cholesterol were added to chick diets, the liver, but not the serum cholesterol level, was reduced; there was no significant effect from saponin when cholesterol was omitted from the diet. Heywang et al (1959) reported that saponin extracted from alfalfa meal and fed to laying hens at .26 and .40% depressed egg production, but this effect disappeared soon after saponin feeding was stopped.…”

Section: Introductionmentioning

confidence: 94%

The Effect of Dietary Alfalfa of Varying Saponin Content on Yolk Cholesterol Level and Layer Performance

et al. 1980

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An experiment was carried out for five 28-day periods to determine the effects of feeding rations containing 10% of three alfalfa meals involving varying levels of saponin on the levels of yolk cholesterol and the performance of Single Comb White Leghorn pullets. A corn-soy ration and similar rations with 10% dehydrated alfalfa meal and low (.03%) and high (.62%) saponin suncured alfalfa meal were fed.No significant differences were found in the level of yolk cholesterol, mean hen-day egg production, Haugh units, specific gravity, and incidence of blood spots among the dietary treatments. Pullets fed the low and high saponin suncured alfalfa diets gained significantly (P<.05) more weight during the experiment than pullets fed the corn-soy diet with dehydrated alfalfa. Mean feed conversions and egg weights were significantly higher and heavier (P<.05), respectively, for pullets fed the alfalfa diets than pullets fed the corn-soy diet. Daily feed consumption was significantly more (P<.05) for pullets fed the high saponin alfalfa diet than the corn-soy diet. These differences may be attributed to the lower energy in the alfalfa diets or the inadequate daily methionine intake per layer on the corn-soy diet. (

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Dietary Saponin, a Factor Which May Reduce Liver and Serum Cholesterol Levels

Cited by 59 publications

References 19 publications

Cholesterol and bile acid balance in Macaca fascicularis. Effects of alfalfa saponins.

Cholesterol and bile acid balance in Macaca fascicularis. Effects of alfalfa saponins.

Effect of caprylic acid andYucca schidigeraextract on production performance, egg quality, blood characteristics, and excreta microflora in laying hens

The Effect of Dietary Alfalfa of Varying Saponin Content on Yolk Cholesterol Level and Layer Performance

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