Dietary Salt Reduction

Chemistry and Antihypertensive Effects of Tempol and Other Nitroxides

“…Thus, tempol corrects salt sensitivity independent of NOS, consistent with its natriuretic actions in the dog that also are independent of NOS (Majid et al, 2004, 2005; Majid and Kopkan, 2007). The observation in these studies that a high salt intake potentiated the reduction in BP with tempol contrasts with the response to all other antihypertensive agents whose effects are reduced during increases in dietary salt (Cappuccio, 2008). …”