Dietary Salt, Kidney Disease, and Cardiovascular Health

Powe, Neil R.; Bibbins‐Domingo, Kirsten

doi:10.1001/jama.2016.5985

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Here we investigated the effects of a more recent factor that is in focus [24, 25], namely sodium chloride (NaCl, table salt), and its effect on HUVECs and their expression of HSP60. We have chosen HUVECs since they are accepted as a representative model of endothelial cells (ECs), easily accessible and the results are reliably extrapolatable to the in vivo situation [26].…”

Section: Introductionmentioning

confidence: 99%

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs

et al. 2017

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Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipopolysaccharide, oxidized low density lipoprotein, advanced glycation end products). In the present study, we show that increasing levels of sodium chloride can also induce an increase in intracellular and surface expression of HSP60 protein in human umbilical vein endothelial cells. In addition, we found that elevated sodium induces apoptosis.

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Section: Introductionmentioning

confidence: 99%

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs

et al. 2017

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“…Moreover, immune cells, blood cells, and platelets also travel through the cardiovascular system. Arteries regulate the blood pressure through molecules within the renin-angiotensin-aldosterone system, a cross-talk mechanism between the kidneys and arteries that is in direct relation to fluid and salt intake [26]. Regular exercise, a physiological means to activate lymphatic circulation, has a beneficial impact on numerous aspects of the cardiovascular system [27].…”

Section: Arteriesmentioning

confidence: 99%

Lymphatic Capillaries in Aging

2020

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The lymphatic system is responsible for fluid drainage from almost every organ in the body. It sustains tissue homeostasis and is also a central part of the immune system. With the discovery of cell-specific markers and transgenic mouse models, it has become possible to gain some insight into the developmental and functional roles of lymphatic endothelial cells (LECs). Only recently, a more direct regulatory role has been assigned to LECs in their functions in immunity responses and chronic diseases. Here, we discuss the changes occurring in aged lymphatic system and the role of lymphatic capillaries in some age-related diseases and experimental animal models.

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“…A low-sodium diet contributes to the reduction of albuminuria by itself and through the enhancement of RAAS blockade 40, 41 . On the other hand, there are drugs other than hypertensives that can positively influence renal function together with BP control, such as statins 43 , fibrates 44 , thiazolidinediones 45 , and antiplatelet therapy 46 .…”

Section: Evidence With Other Therapies and Renal Outcomesmentioning

confidence: 99%

The impact of antihypertensives on kidney disease

Márquez¹,

Ruiz‐Hurtado

Ruilope

2017

F1000Res

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Arterial hypertension and chronic kidney disease (CKD) are intimately related. The control of blood pressure (BP) levels is strongly recommended in patients with CKD in order to protect the kidney against the accompanying elevation in global cardiovascular (CV) risk. Actually, the goal BP in patients with CKD involves attaining values <140/90 mmHg except if albuminuria is present. In this case, it is often recommended to attain values <130/80 mmHg, although some guidelines still recommend <140/90 mmHg. Strict BP control to values of systolic BP around 120 mmHg was recently shown to be safe in CKD according to data from the SPRINT trial, albeit more data confirming this benefit are required. Usually, combination therapy initiated with an angiotensin receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEi) and commonly followed by the addition of a calcium channel blocker and a diuretic is needed. Further studies are required as well as new drugs in particular after the positive data obtained from new oral anti-diabetic drugs.

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Dietary Salt, Kidney Disease, and Cardiovascular Health

Cited by 4 publications

References 14 publications

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs

Lymphatic Capillaries in Aging

The impact of antihypertensives on kidney disease

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