Dietary risk factors for the development of insulin resistance in adolescent girls: a 3-year prospective study

White, James; Jago, Russell; Thompson, Janice L.

doi:10.1017/s1368980012004983

Cited by 19 publications

(23 citation statements)

References 48 publications

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“…Nutritional factors have been associated with IR and related inflammatory states in different populations [27,28]. In the studied population, participants with IR showed significantly higher consumptions of simple carbohydrates and dietary cholesterol and low intakes of dietary fiber than their NIR counterparts.…”

Section: Discussionmentioning

confidence: 93%

Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance

et al. 2019

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This study aimed to nutrigenetically screen gene-diet and gene-metabolic interactions influencing insulin resistance (IR) phenotypes. A total of 232 obese or overweight adults were categorized by IR status: non-IR (HOMA-IR (homeostatic model assessment -insulin resistance) index ≤ 2.5) and IR (HOMA-IR index > 2.5). A weighted genetic risk score (wGRS) was constructed using 95 single nucleotide polymorphisms related to energy homeostasis, which were genotyped by a next generation sequencing system. Body composition, the metabolic profile and lifestyle variables were evaluated, where individuals with IR showed worse metabolic outcomes. Overall, 16 obesity-predisposing genetic variants were associated with IR (p < 0.10 in the multivariate model). The wGRS strongly associated with the HOMA-IR index (adj. R squared = 0.2705, p < 0.0001). Moreover, the wGRS positively interacted with dietary intake of cholesterol (P int. = 0.002), and with serum concentrations of C-reactive protein (P int. = 0.008) regarding IR status, whereas a negative interaction was found regarding adiponectin blood levels (P int. = 0.006). In conclusion, this study suggests that interactions between an adiposity-based wGRS with nutritional and metabolic/endocrine features influence IR phenotypes, which could facilitate the prescription of personalized nutrition recommendations for precision prevention and management of IR and diabetes.

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Section: Discussionmentioning

confidence: 93%

Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance

et al. 2019

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“…After grouping studies in accordance with outcomes of interest, one cross-sectional study (56) Fibre in childhoodinvestigating dietary fibre intake and folate status and one repeated publication (57) were excluded. Additionally, after performing adapted search commands on other databases and scanning the reference lists from included studies, two further cross-sectional studies (70,71) and five prospective cohort (64,(72)(73)(74)(75) studies were identified and included. In total, fifteen cross-sectional studies and eleven cohort studies were included in the present review.…”

Section: Search Strategymentioning

confidence: 99%

Dietary fibre and health in children and adolescents

2015

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The role of dietary fibre in promoting sustained health has been studied for several decades and in adults there is good evidence that diets rich in high-fibre foods reduce the risk of chronic diseases, including CVD and cancer. Research in this area, however, has been hampered by uncertainties about the definition of dietary fibre which has resulted in many studies measuring fibre in different ways. There is also a wide range of properties and actions of different fibres in the human body, depending on their solubility, viscosity and fermentability by the colonic microbiota. This review considers the epidemiological evidence for dietary fibre and health in children and the current dietary recommendations and measured intakes in several countries using national surveys. In children and adolescents, there is a particular lack of relevant research on which to formulate appropriate dietary fibre recommendations and these are often based on extrapolation from adult data. However, children are not little adults and have differing physiology and nutritional needs as they grow. The dietary recommendations in different countries are based on varying premises and daily amounts. Intakes vary from country to country and on the whole do not meet recommendations. Much more research is needed in children to fully understand the impact of dietary fibre on growth and health in the young to allow more appropriate recommendations to be made.

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“…This situation constitutes a primary risk factor for the development of insulin resistance (IR), which is a phenomenon that plays a major role in the emergence of cardiometabolic disorders. 3 Dietary components can also influence insulin sensitivity. Evidence indicates a positive association between IR and the excessive intake of energy-dense foods rich in simple carbohydrates and fats, especially saturated and trans fats.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Insulin Resistance and Association With Metabolic Risk Factors and Food Consumption in Adolescents - Recife/Brazil

Andrade

Oliveira

Leal

et al. 2020

Rev. paul. pediatr.

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Objective: To identify the prevalence of insulin resistance in adolescents and its associations with metabolic factors and food intake. Methods: Cross-sectional study conducted with a stratified, complex, school-based sample. The subjects were adolescents (n=1,081) who participated in the Study of Cardiovascular Risk in Adolescents in the city of Recife (Pernambuco, Brazil). We analyzed demographic, socioeconomic, behavioral, anthropometric, biochemical, and dietary variables. Insulin resistance was defined as HOMA-IR>75th percentile. A Poisson multivariate regression model with robust variance adjustment was used, and variables with p≤0.05 in the final model were considered statistically associated with insulin resistance. Results: Median age was 14 years (interquartile range: 13-16 years), and 25.3% of the sample showed insulin resistance. The variables associated with insulin resistance in the final model were age, body mass index-for-age (BMI/A), biochemical markers (triglycerides and high-density lipoprotein cholesterol) and saturated fat intake, with insulin resistance being more prevalent in individuals whose consumption of this type of fat was below the median of the sample distribution. Conclusions: Insulin resistance was prevalent in the adolescents analyzed and was significantly associated with metabolic variables and saturated fat intake.

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Dietary risk factors for the development of insulin resistance in adolescent girls: a 3-year prospective study

Cited by 19 publications

References 48 publications

Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance

Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance

Dietary fibre and health in children and adolescents

Prevalence of Insulin Resistance and Association With Metabolic Risk Factors and Food Consumption in Adolescents - Recife/Brazil

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