Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation

Parker, Kristopher D.; Maurya, Akhilendra Kumar; Ibrahim, Hend; Rao, Sangeeta; Hove, Petronella R.; Kumar, Dileep; Kant, Rama; Raina, B. L.; Agarwal, Rajesh; Kuhn, Kristine A.; Raina, Komal; Ryan, Elizabeth P.

doi:10.3390/biomedicines9020144

Cited by 23 publications

(23 citation statements)

References 60 publications

(81 reference statements)

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“…For patients with colon cancer, antibiotic therapy is even recommended as an immunotherapy strategy [ 100 , 101 ]. After antibiotic manipulation of the gut microbiota, a reduction in tumor load was detected, which supported the hypothesis of bacterial involvement in carcinogenesis [ 102 ]. For example, metronidazole can eradicate Fusobacterium colonization and inhibit the proliferation of CRC [ 103 ].…”

Section: Effect Of Antibioticssupporting

confidence: 58%

Effect of gut microbiota in the colorectal cancer and potential target therapy

Zhu

Yang

et al. 2022

Discov Onc

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The symbiotic interaction between gut microbiota and the digestive tract is an important factor in maintaining the intestinal environment balance. Colorectal cancer (CRC) is a complex disease involving the interaction between tumour cells and a large number of microorganisms. The microbiota is involved in the occurrence, development and prognosis of colorectal cancer. Several microbiota species have been studied, such as Fusobacterium nucleatum (F.nucleatum), Enterotoxigenic Bacteroidesfragilis (ETBF), Streptococcus bovis (S. bovis), Lactobacillus, and Bifidobacterium. Studies about the interaction between microbiota and CRC were retrieved from Embase, PubMed, Ovid and Web of Science up to 21 Oct 2021. This review expounded on the effect of microbiota on CRC, especially the dysregulation of bacteria and carcinogenicity. The methods of gut microbiota modifications representing novel prognostic markers and innovative therapeutic strategies were also described.

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Section: Effect Of Antibioticssupporting

confidence: 58%

Effect of gut microbiota in the colorectal cancer and potential target therapy

Zhu

Yang

et al. 2022

Discov Onc

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“…26 Notably, germfree mice receiving human fecal transplantation with rice-bran modified stool microbes showed significantly less colon cancerous lesions compared to mice humanized by stool microbes from control fed adults (without rice-bran intervention). 27 Taken together, these studies provided convincing rationale for testing the hypothesis that RB and Bifidobacterium-fermented rice bran (FRB) can restructure the "high risk" or dysbiotic gut microbiota toward the colonization of microbial communities that protect against CRC growth and progression. However, the microbiomemediated and microbiota-independent colonic tissue/tumor effects and metabolic pathways impacted following dietary RB or FRB remain largely unknown.…”

Section: Introductionmentioning

confidence: 98%

Gender‐based effect of absence of gut microbiota on the protective efficacy of Bifidobacterium longum‐fermented rice bran diet against inflammation‐associated colon tumorigenesis

Kumar

Maurya

Parker

et al. 2022

Molecular Carcinogenesis

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Dietary rice bran (RB) has shown capacity to influence metabolism by modulation of gut microbiota in individuals at risk for colorectal cancer (CRC), which warranted attention for delineating mechanisms for bidirectional influences and cross‐feeding between the host and RB‐modified gut microbiota to reduce CRC. Accordingly, in the present study, fermented rice bran (FRB, fermented with a RB responsive microbe Bifidobacterium longum), and non‐fermented RB were fed as 10% w/w (diet) to gut microbiota‐intactspf or germ‐free micegf to investigate comparative efficacy against inflammation‐associated azoxymethane/dextran sodium sulfate (AOM/DSS)‐induced CRC. Results indicated both microbiota‐dependent and independent mechanisms for RB meditated protective efficacy against CRC that was associated with reduced neoplastic lesion size and local‐mucosal/systemic inflammation, and restoration of colonic epithelial integrity. Enrichment of beneficial commensals (such as, Clostridiales, Blautia, Roseburia), phenolic metabolites (benzoate and catechol metabolism), and dietary components (ferulic acid‐4 sulfate, trigonelline, and salicylate) were correlated with anti‐CRC efficacy. Germ‐free studies revealed gender‐specific physiological variables could differentially impact CRC growth and progression. In the germ‐free females, the RB dietary treatment showed a ∼72% reduction in the incidence of colonic epithelial erosion when compared to the ∼40% reduction in FRB‐fed micegf. Ex vivo fermentation of RB did not parallel the localized‐protective benefits of gut microbial metabolism by RB in damaged colonic tissues. Findings from this study suggest potential needs for safety considerations of fermented fiber rich foods as dietary strategies against severe inflammation‐associated colon tumorigenesis (particularly with severe damage to the colonic epithelium).

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“…The mice were transfaunated with rice bran-modified microbiota collected from human stool during fecal microbiota transplant. The results showed that TMAO and tartrate, being associated with CRC development, were reduced in murine colon tissues [40]. Nevertheless, these findings may vary under different circumstances.…”

Section: Discussionmentioning

confidence: 81%

Is There any Possible Association Between Trimethylamine N-Oxide (TMAO) and Cancer? A Review Study

Khodabakhshi

Rooholamini

2021

JOHE

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Article InfoBackground: During the transit of digested animal source foods, gut microbiota synthesize metabolites that can affect the body cells. One of these metabolites, i.e.Trimethylamine (TMA) that is an intermediary metabolite, ultimately leads to the production of Trimethylamine N-oxide (TMAO). Several studies have been conducted to show the association between TMAO and different diseases. This article aimed to search literature in order to review published findings about the possible association between TMAO and cancer. Materials and Methods:In this literature review, a comprehensive electronic search of different databases was done using "Trimethylamine N-oxide" and "cancer" as the main keywords.Result: Research suggests that TMAO can be related to the increased risk of cancer.The results showed a higher level of serum TMAO in cancer patients, most importantly colorectal cancer (CRC), than in healthy controls. Nevertheless, inflammation, oxidative stress, and DNA damage could be the reasons for the link between TMAO and cancer.Limiting dietary intake of animal products can reduce levels of TMAO. Conclusion:It is concluded that a higher rate of TMAO production could potentially be associated with the development of different types of cancers, particularly CRC.

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Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation

Cited by 23 publications

References 60 publications

Effect of gut microbiota in the colorectal cancer and potential target therapy

Effect of gut microbiota in the colorectal cancer and potential target therapy

Gender‐based effect of absence of gut microbiota on the protective efficacy of Bifidobacterium longum‐fermented rice bran diet against inflammation‐associated colon tumorigenesis

Is There any Possible Association Between Trimethylamine N-Oxide (TMAO) and Cancer? A Review Study

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