Dietary resveratrol supplementation on growth performance, immune function and intestinal barrier function in broilers challenged with lipopolysaccharide

Zhang, L L; Gong, Joshua; Li, Jiahui; Hao, Yaoyao; Xu, Hongjian; Liu, Y S; Feng, Zhichun

doi:10.1016/j.psj.2023.102968

Cited by 10 publications

(5 citation statements)

References 65 publications

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“…Resveratrol has been shown to have a broad range of therapeutic effects, such as its anti-inflammatory, antioxidant, platelet-inhibiting, hyperlipidemic, immunomodulatory, anti-carcinogenic, cardioprotective, vasodilatory, and neuroprotective activity [5][6][7][8][9]. It has been reported that resveratrol can sustain or improve human cerebrovascular functions [10], modulate in vitro angiogenesis by altering vascular endothelial growth factor (VEGF) expression and the formation of new vascular networks [11], stimulate human immune cell functions [12], boost rat cell viability and proliferation [13], reduce mitochondrial respiratory dysfunction, and boost cellular reprogramming in human fibroblasts derived from patients with a mammalian target of rapamycin (mTOR) pathway deficiency [14]. Resveratrol has been shown to also have neuroprotective [15], hepatoprotective [16], and cardioprotective [17,18] effects.…”

Section: Introductionmentioning

confidence: 99%

The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development

Farhan,

Rizvi

2023

Nutrients

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Resveratrol is a stilbenoid from red grapes that possesses a strong antioxidant activity. Resveratrol has been shown to have anticancer activity, making it a promising drug for the treatment and prevention of numerous cancers. Several in vitro and in vivo investigations have validated resveratrol’s anticancer capabilities, demonstrating its ability to block all steps of carcinogenesis (such as initiation, promotion, and progression). Additionally, resveratrol has been found to have auxiliary pharmacological effects such as anti-inflammatory, cardioprotective, and neuroprotective activity. Despite its pharmacological properties, several obstacles, such as resveratrol’s poor solubility and bioavailability, as well as its adverse effects, continue to be key obstacles to drug development. This review critically evaluates the clinical trials to date and aims to develop a framework to develop resveratrol into a clinically viable drug.

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Section: Introductionmentioning

confidence: 99%

The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development

Farhan,

Rizvi

2023

Nutrients

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“…Nevertheless, decreased IgG concentrations can be comparable to effects observed with the addition of salinomycin to broiler chicken diets (Bortoluzzi et al, 2023) or the incorporation of probiotic preparations in the feed or "in ovo" (Oladokun and Adewole, 2023). It is well known that challenged birds typically show elevated immunoglobulin levels in the blood serum (Zhang et al, 2023). Therefore, contrary to the latter findings, the reduced IgG levels observed in the HI treatment suggests that lauric acid may potentially act against pathogenic microbiota and enhance immune function.…”

Section: Discussionmentioning

confidence: 80%

Implementation of a metabolizable energy regression model for black soldier fly larvae fat in broiler chicken diets: effect on growth performance, nutrient digestibility, and selected physiological indices

Kierończyk,

Kaczmarek,

Hejdysz

et al. 2024

J. Anim. Feed Sci.

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“…Furthermore, dietary supplementation with 150 mg/kg of bisdemethoxycurcumin (a curcuminoid) demonstrated a positive effect against LPS-induced small intestinal oxidative damage by upregulating antioxidant-related genes such as CAT, γ-GCLc, Nrf2, HO-1, and NQO1 [ 90 ]. Despite the negative alterations caused by LPS challenge on the intestinal barrier function and inflammation in broilers, these effects have been found to be significantly restored with the supplementation of 400 mg/kg of resveratrol, which leads to the downregulation of pro-inflammatory cytokines and to the upregulation of genes related to the intestinal barrier, thereby ultimately improving immune function damage and alleviating intestinal inflammation [ 91 ].…”

Section: Supplementation Of Natural Antioxidants In the Diet Of Broil...mentioning

confidence: 99%

Nutrigenomics of Natural Antioxidants in Broilers

Kouvedaki,

Pappas,

Surai

et al. 2024

Antioxidants

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The broiler industry supplies high-quality animal protein to the world. The ban of antibiotics as growth promoters has opened the way for plenty of phytochemicals and antioxidants to be explored. This study summarizes the use of natural antioxidants in a broiler diet as a way through which to deal with stressors, as well as their effects on the expression of various genes. The transcriptional factors and genes involved in the regulation of redox homeostasis are described and emphasis is placed on nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B. Sources such as fruits, vegetables, spices, mushrooms, and algae contain numerous natural antioxidant compounds. The antioxidant activity of these compounds has also been confirmed at the genome level. This study focuses on the regulation of oxidative stress-related genes, as well as on genes that regulate the inflammatory response, apoptosis, response to heat stress, lipid metabolism, and the intestinal barrier status. The natural compounds presented include, but are not limited to, the following: rutin, lycopene, magnolol, genistein, hesperidin, naringin, quercetin, curcumin, bisdemethoxycurcumin, resveratrol, astaxanthin, squalene, pterostilbene, protocatechuic acid, taraxasterol, myricetin, and proanthocyanidins. Several studies have revealed a dose-dependent action. Future studies should focus on the role of phytogenic compounds as antibiotic alternatives in relation to gut microbiota and their role in eubiosis.

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Dietary resveratrol supplementation on growth performance, immune function and intestinal barrier function in broilers challenged with lipopolysaccharide

Cited by 10 publications

References 65 publications

The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development

The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development

Implementation of a metabolizable energy regression model for black soldier fly larvae fat in broiler chicken diets: effect on growth performance, nutrient digestibility, and selected physiological indices

Nutrigenomics of Natural Antioxidants in Broilers

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