Dietary Restriction modulates sleep in Drosophila Melanogaster

Abstract

Sleep deprivation has catastrophic metabolic and physiological consequences in numerous organisms, from fruit flies to humans. Dietary restriction (DR), a limitation of calories in the absence of malnutrition, has been shown to dramatically improve the health and longevity of a number of species, and evidence shows that this intervention may have the potential to overcome some of the molecular and neurological deficits seen in aging and sleep decline. Using a 17‐beam infrared‐light paradigm as well as gene expression analysis, this study demonstrates that restriction of amino acids has significant effects on sleep/wake patterns in Drosophila Melanogaster, as well as alters the expression of genes essential to maintaining homeostatic sleep.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.