Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study

Ramsey, Jon J.; Colman, Ricki J.; Binkley, Neil; Christensen, Jens D.; Gresl, Theresa A.; Kemnitz, Joseph W.; Weindruch, Richard

doi:10.1016/s0531-5565(00)00166-2

Cited by 179 publications

(137 citation statements)

References 45 publications

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“…In comparison with control and CR group, the incidences of both neoplasia and cardiovascular disease was reduced by 50%. Especially, improvement in insulin sensitivity conferred by CR, has been consistent and remarkable [14,15]. Improved glucose homeostasis was maintained, inducing that diabetes was prevented by CR.…”

Section: Biology Of Human and Animals In Crmentioning

confidence: 93%

Biology of Human Aging and Recent Nutrition Therapy

Bando¹,

Ebe²,

Bando³

2017

Mol Biol

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Discussion concerning Calorie Restriction (CR) and low carbohydrate diet (LCD) has continued for years. Authors have developed research of LCD using super LCD with 12% of carbohydrate. The biology of human aging includes study between human and mammalian such as mice, rhesus monkeys. Moderate CR reduced age-related mortality, incidence of diabetes, cancer, cardiovascular disease. By very low calorie diet (VLCD), body weight can be reduced, but the diabetic pathological state remains. Besides CR and LCD, Zone, Ornish, LEARN Diets and Mediterranean style can be applicable. There are very low-carbohydrate ketogenic diet (VLCKD), Moderate-LCD, HighCarbohydrate Diet, as related with the definition of LCD. Morbus (M) value was investigated for clinical practice of LCD, in which M value was remarkably improved by LCD treatment.

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Section: Biology Of Human and Animals In Crmentioning

confidence: 93%

Biology of Human Aging and Recent Nutrition Therapy

Bando¹,

Ebe²,

Bando³

2017

Mol Biol

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show abstract

“…More detailed descriptions of the design and methodology of this study have been reported (Colman et al 1998;Kemnitz et al 1993;Ramsey et al 2000). This protocol was carried out with the approval of the Institutional Animal Care and Use Committee of the Graduate School of the University of Wisconsin, Madison.…”

Section: Animals and Study Designmentioning

confidence: 99%

“…The ability of CR to increase life span is also seen in spiders, fish, water fleas, and other animals (Weindruch and Walford 1988). Studies (Ingram et al 1990;Kemnitz et al 1993;Colman et al 2009;Ramsey et al 2000;Mattison et al 2003) are currently underway exploring the effects of moderate (∼30%) CR in rhesus monkeys, but information on the skeletal effects of this intervention remains limited.…”

Section: Introductionmentioning

confidence: 99%

Skeletal effects of long-term caloric restriction in rhesus monkeys

Colman

Beasley

Allison

et al. 2011

AGE

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Age-related bone loss is well established in humans and is known to occur in nonhuman primates. There is little information, however, on the effect of dietary interventions, such as caloric restriction (CR), on age-related bone loss. This study examined the effects of long-term, moderate CR on skeletal parameters in rhesus monkeys. Thirty adult male rhesus monkeys were subjected to either a restricted (R, n0 15) or control (C, n015) diet for 20 years and examined throughout for body composition and biochemical markers of bone turnover. Total body, spine, and radius bone mass and density were assessed by dualenergy X-ray absorptiometry. Assessment of biochemical markers of bone turnover included circulating serum levels of osteocalcin, carboxyterminal telopeptide of type I collagen, cross-linked aminoterminal telopeptide of type I collagen, parathyroid hormone, and 25(OH)vitamin D. Overall, we found that bone mass and density declined over time with generally higher levels in C compared to R animals. Circulating serum markers of bone turnover were not different between C and R with nonsignficant diet-by-time interactions. We believe the lower bone mass in R animals reflects the smaller body size and not pathological osteopenia.

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“…To rigorously address this question, studies in NHPs were initiated at the National Institute on Aging (Lane et al 1992) as well as the Wisconsin National Primate Research Center (Ramsey et al 2000). Reports from both institutes showed that CR produced many of the beneficial physiological effects observed in rodents such as improved cardiovascular and glucoregulatory function (Cefalu et al 1999;Lane et al 1999).…”

Section: Caloric Restrictionmentioning

confidence: 99%

Improving immunity in the elderly: current and future lessons from nonhuman primate models

Meyer

Kerns

Haberthur

et al. 2011

AGE

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The immune system must overcome daily challenges from pathogens to protect the body from infection. The success of the immune response to infection relies on the ability to sense and evaluate microbial threats and organize their elimination, while limiting damage to host tissues. This delicate balance is achieved through coordinated action of the innate and adaptive arms of the immune system. Aging results in several structural and functional changes in the immune system, often described under the umbrella term "immune senescence". Age-related changes affect both the innate and adaptive arms of the immune system and are believed to result in increased susceptibility and severity of infectious diseases, which is further exacerbated by reduced vaccine efficacy in the elderly. Therefore, multiple strategies to improve immune function in the aged are being investigated. Traditionally, studies on immune senescence are conducted using inbred specific pathogen free (SPF) rodents. This animal model has provided invaluable insight into the mechanisms of aging. However, the limited genetic heterogeneity and the SPF status of this model restrict the successful transfer of immunological discoveries between murine models and the clinical setting. More recently, nonhuman primates (NHPs) have emerged as a leading translational model to investigate immune senescence and to test interventions aimed at delaying/reversing agerelated changes in immune function. In this article, we review and summarize advances in immunorestorative approaches investigated in the NHP model system and discuss where the NHP model can support the development of novel therapeutics.

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Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study

Cited by 179 publications

References 45 publications

Biology of Human Aging and Recent Nutrition Therapy

Biology of Human Aging and Recent Nutrition Therapy

Skeletal effects of long-term caloric restriction in rhesus monkeys

Improving immunity in the elderly: current and future lessons from nonhuman primate models

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