Dietary restriction and ageing: Recent evolutionary perspectives

Auley, Mark T. Mc

doi:10.1016/j.mad.2022.111741

Cited by 7 publications

(3 citation statements)

References 199 publications

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“…Dietary restriction (DR) is one of the most robust interventions used to study the effect of resource limitation on phenotypic, physiological and molecular plasticity. DR affects life-history traits antagonistically; it improves survival at the expense of growth and current reproduction 4 . In response to nutritional limitations, organisms undergo critical changes in gene expression to adapt their energy metabolism to the prevailing conditions through molecular and physiological functions 5 , 6 .…”

Section: Introductionmentioning

confidence: 99%

Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails

Reda,

Ndunguru,

Csernus

et al. 2024

Sci Rep

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Limited resources affect an organism’s physiology through the conserved metabolic pathway, the mechanistic target of rapamycin (mTOR). Males and females often react differently to nutritional limitation, but whether it leads to differential mTOR pathway expression remains unknown. Recently, we found that dietary restriction (DR) induced significant changes in the expression of mTOR pathway genes in female Japanese quails (Coturnix japonica). We simultaneously exposed 32 male and female Japanese quails to either 20%, 30%, 40% restriction or ad libitum feeding for 14 days and determined the expression of six key genes of the mTOR pathway in the liver to investigate sex differences in the expression patterns. We found that DR significantly reduced body mass, albeit the effect was milder in males compared to females. We observed sex-specific liver gene expression. DR downregulated mTOR expression more in females than in males. Under moderate DR, ATG9A and RPS6K1 expressions were increased more in males than in females. Like females, body mass in males was correlated positively with mTOR and IGF1, but negatively with ATG9A and RS6K1 expressions. Our findings highlight that sexes may cope with nutritional deficits differently and emphasise the importance of considering sexual differences in studies of dietary restriction.

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Section: Introductionmentioning

confidence: 99%

Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails

Reda,

Ndunguru,

Csernus

et al. 2024

Sci Rep

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“…Circadian clock disruption has been implicated in advanced aging and the longevity response to caloric or dietary restriction (CR or DR) (Froy, 2018; Galikova and Flatt, 2010; Manoogian and Panda, 2017; Nakahata and Fukada, 2022; Zhu et al, 2022). DR, reduction in food intake without causing malnutrition, robustly extends longevity in various animal models including yeast, worms, flies, and monkeys (Green et al, 2022; Mc Auley, 2022). Yet, the molecular mechanisms by which DR delays aging are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity inDrosophila

Hwangbo

Kwon

Iwanaszko

et al. 2023

Preprint

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Circadian clocks may mediate lifespan extension by caloric or dietary restriction (DR). We find that the core clock transcription factor Clock is crucial for a robust longevity and fecundity response to DR in Drosophila. To identify clock-controlled mediators, we performed RNA-sequencing from abdominal fat bodies across the 24 h day after just 5 days under control or DR diets. In contrast to more chronic DR regimens, we did not detect significant changes in the rhythmic expression of core clock genes. Yet we discovered that DR induced de novo rhythmicity or increased expression of rhythmic clock output genes. Network analysis revealed that DR increased network connectivity in one module comprised of genes encoding proteasome subunits. Adult, fat body specific RNAi knockdown demonstrated that proteasome subunits contribute to DR-mediated lifespan extension. Thus, clock control of output links DR-mediated changes in rhythmic transcription to lifespan extension.

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“…A guided reduction in food intake or calorie restriction constitutes another lifestyle modification-mediated anti-ageing intervention. By diminishing both the age-related decline in physiological fitness and the risk of ARD development, calorie restriction extends the healthy lifespan [176,177] in that increases in telomerase activity and SIRT1 and SIRT6 expressions appear to play critical roles [178,179]. Results of a two-year clinical trial conducted with healthy and non-obese individuals show that calorie restriction may also improve overall health and wellbeing by significantly attenuating oxidative stress [180].…”

Section: Calorie Restrictionmentioning

confidence: 99%

Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies

Bayraktutan

2023

IJMS

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Ageing constitutes the biggest risk factor for poor health and adversely affects the integrity and function of all the cells, tissues, and organs in the human body. Vascular ageing, characterised by vascular stiffness, endothelial dysfunction, increased oxidative stress, chronic low-grade inflammation, and early-stage atherosclerosis, may trigger or exacerbate the development of age-related vascular diseases, which each year contribute to more than 3.8 million deaths in Europe alone and necessitate a better understanding of the mechanisms involved. To this end, a large number of recent preclinical and clinical studies have focused on the exponential accumulation of senescent cells in the vascular system and paid particular attention to the specific roles of senescence-associated secretory phenotype, proteostasis dysfunction, age-mediated modulation of certain microRNA (miRNAs), and the contribution of other major vascular risk factors, notably diabetes, hypertension, or smoking, to vascular ageing in the elderly. The data generated paved the way for the development of various senotherapeutic interventions, ranging from the application of synthetic or natural senolytics and senomorphics to attempt to modify lifestyle, control diet, and restrict calorie intake. However, specific guidelines, considering the severity and characteristics of vascular ageing, need to be established before widespread use of these agents. This review briefly discusses the molecular and cellular mechanisms of vascular ageing and summarises the efficacy of widely studied senotherapeutics in the context of vascular ageing.

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Dietary restriction and ageing: Recent evolutionary perspectives

Cited by 7 publications

References 199 publications

Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails

Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails

Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity inDrosophila

Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies

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