Dietary Quercetin Increases Colonic Microbial Diversity and Attenuates Colitis Severity in Citrobacter rodentium-Infected Mice

Lin, Rui; Piao, Meiyu; Song, Yan

doi:10.3389/fmicb.2019.01092

Cited by 120 publications

(83 citation statements)

References 42 publications

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“…Notably, several investigations have also identified the dietary intake of polyphenols as a potential option for CVD management (Tangney and Rasmussen ; Ding et al ). Epidemiological studies have also correlated a decreased risk of CVD onset with an increased intake of dietary quercetin, a natural flavonoid compound found in vegetables and fruits (Peterson et al ; Hong and Piao ; Lin et al ). This correlation is supported by a preclinical study in which the administration of a quercetin supplement reduced the progression of atherosclerosis (Shen et al ).…”

Section: Introductionmentioning

confidence: 99%

Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

et al. 2019

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Aims Epidemiological studies have correlated cardiovascular disease and atherosclerosis with lifestyle factors such as sedentary behaviour and a high‐calorie diet. Recent studies of pathogenesis have highlighted the significance of the intestinal microbiota and chronic inflammation with respect to both the onset and development of atherosclerosis. This study examined the hypothesis that the oral administration of quercetin to low‐density lipoprotein receptor‐null (Ldlr−/−) mice would improve gut health by altering the gut microbiota and controlling the levels of atherogenic lipid metabolites and proinflammatory mediators in the intestine and serum. Methods and Results Mice were maintained on a high‐fat diet with or without oral quercetin administration for 12 weeks. Quercetin treatment suppressed body weight gains and reduced the extent of atherosclerotic lesions in the aortic sinus. Reduced malondialdehyde and increased interleukin 6 levels further indicated the protective effect of quercetin against immune/inflammatory responses and oxidative stress. Furthermore, quercetin led to decreased intestinal levels of cholesterol, lysophosphatidic acids and atherogenic lysophosphatidylcholine (LPC 18:1) and an increased level of coprostanol. A phylum‐level microbial analysis revealed that quercetin treatment reduced the abundance of Verrocomicrobia and increased microbiome diversity and the abundances of Actinobacteria, Cyanobacteria and Firmicutes. A Spearman analysis revealed negative correlations of Actinobacteria with intestinal and plasma LPC 18:1 and caecal cholesterol levels and of Firmicutes and Cyanobacteria with the plasma LPC 18:1 level. Conclusions This study demonstrated the ability of quercetin treatment to reduce lipid levels, as well as the areas of atherosclerotic lesions and sizes of plaques. This treatment also altered the composition of the gut microbiota and decreased the levels of atherogenic lipid metabolites. Significance and Impact of the Study Oral quercetin treatment may represent a new approach to mitigating the onset and development of atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

et al. 2019

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“…In vivo studies have shown changes in microbial communities due to rice bran or quercetin and describe the improvement of colonization resistance and reduction of colon cancer (11, 14, 53). However, these studies are marked by high variations of the microbiota composition likely due to host factors.…”

Section: Discussionmentioning

confidence: 99%

“…Enterobacteriaceae and Fusobacteriaceae were reported to be positively related to quercetin supplementation whereas Suttrellaceae and Oscillospiraceae were found to be negatively correlated (26). However, Lei et al, (2019) reported an increase in abundances of Bifidobacterium, Bacteroides, Lactobacillus and Clostridium , with a reduction of Fusobacterium and Enterococcus in mice fed with quercetin (11). With higher resolution and removal of host factors, our results contrast with both studies and show enrichment of Acidaminococcus intestini and decreased abundances of E. limosum, E. faecalis, A. caccae, D. longicatena and C. catus .…”

Section: Discussionmentioning

confidence: 99%

“…Some of the dietary components are known to enhance host health by promoting the growth of beneficial bacteria in the gut, termed as “prebiotics” (7, 8). Rice bran and quercetin have been used as prebiotics in mice and pig experiments, showing a significant improvement of the gut microbiota (9-11). Rice bran is a byproduct of the rice milling process and is an easily available, affordable, sustainable, and globally produced source of prebiotics.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, quercetin (3,3′,4′,5,7-pentahydroxyflavone) represents an important subgroup of flavonoids found in fruits and leafy vegetables (16). It has received substantial attention in the past few years from the scientific community due to its anti-inflammatory effects (17, 18) and its potential health-promoting properties in the treatment or prevention of cardiovascular diseases (19), lung and colorectal cancers (20, 21), and colitis (11, 22). Furthermore, the mammalian body can endure high levels of quercetin without any significant adverse health effects (23) suggesting its potential food application.…”

Section: Introductionmentioning

confidence: 99%

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Rice Bran and Quercetin Produce a Positive Synergistic Effect on Human Gut Microbiota, Elevate the Level of Propionate, and Reduce the Population ofEnterobacteriaceaefamily when Determined using a Bioreactor Model

Ghimire

Wongkuna

Sankaranarayanan

et al. 2020

Preprint

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Diet is one of the prominent determinants of gut microbiota composition significantly impacting human health. Recent studies with dietary supplements such as rice bran and quercetin have been shown to provide a beneficial impact on the host by positively influencing the gut microbiota. However, the specific bacterial species impacted when rice bran or quercetin is present in the diet is not well understood. Therefore, in this study, we used a minibioreactor array system as a model to determine the effect of quercetin and rice bran individually, as well as in combination, on gut microbiota without the confounding host factors. We found that rice bran exerts higher shift in gut microbiome composition when compared to quercetin. At the species level, Acidaminococcus intestini was the only significantly enriched taxa when quercetin was supplemented, while 15 species were enriched in rice bran supplementation and 13 were enriched when quercetin and rice bran were supplemented in combination. When comparing the short chain fatty acid production, quercetin supplementation significantly enriched isobutyrate production while propionate dominated the quercetin and rice bran combined group. Higher levels of propionate were highly correlated to the lower abundance of the potentially pathogenic Enterobacteriaceae family. These findings suggest that the combination of rice bran and quercetin serve to enrich beneficial bacteria and reduce potential opportunistic pathogens. However, further in vivo studies are necessary to determine the synergistic effect of rice bran and quercetin on host health and immunity.ImportanceRice bran and quercetin are dietary components that shape host health by interacting with the gut microbiome. Both these substrates have been reported to provide nutritional and immunological benefits individually. However, considering the complexity of the human diet, it is useful to determine how the combination of food ingredients such as rice bran and quercetin influences the human gut microbiota. Our study provides insights into how these ingredients influence microbiome composition alone and in combination in vitro. This will allow us to identify which species in the gut microbiome are responsible for biotransformation of these dietary ingredients.. Such information is helpful for the development of synbiotics to improve gut health and immunity.

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Association between intestinal microbiota and inflammatory bowel disease

Zhang

Yang

et al. 2022

Anim Models and Exp Med

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Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), has emerged as a global disease with high incidence, long duration, devastating clinical symptoms, and low curability (relapsing immune response and barrier function defects). Mounting studies have been performed to investigate its pathogenesis to provide an ever-expanding arsenal of therapeutic options, while the precise etiology of IBD is not completely understood yet. Recent advances in highthroughput sequencing methods and animal models have provided new insights into the association between intestinal microbiota and IBD. In general, dysbiosis characterized by an imbalanced microbiota has been widely recognized as a pathology of IBD. However, intestinal microbiota alterations represent the cause or result of IBD process remains unclear. Therefore, more evidences are needed to identify the precise role of intestinal microbiota in the pathogenesis of IBD. Herein, this review aims to outline the current knowledge of commonly used, chemically induced, and infectious mouse models, gut microbiota alteration and how it contributes to IBD, and dysregulated metabolite production links to IBD pathogenesis.

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Dietary Quercetin Increases Colonic Microbial Diversity and Attenuates Colitis Severity in Citrobacter rodentium-Infected Mice

Cited by 120 publications

References 42 publications

Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

Rice Bran and Quercetin Produce a Positive Synergistic Effect on Human Gut Microbiota, Elevate the Level of Propionate, and Reduce the Population ofEnterobacteriaceaefamily when Determined using a Bioreactor Model

Association between intestinal microbiota and inflammatory bowel disease

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