Dietary Protein Intake and Associated Risks for Atopic Dermatitis, Intrinsic Eczema, and Allergic Sensitization among Young Chinese Adults in Singapore/Malaysia: Key Findings from a Cross-sectional Study

Lim, Jun Jie; Reginald, Kavita; Say, Yee-How; Liu, Mei Hui; Chew, Fook Tim

doi:10.1016/j.xjidi.2023.100224

Cited by 1 publication

(1 citation statement)

References 54 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The multifaceted nature of AD underscores the complex interplay of genetic predispositions [3,4], immunological responses [5], environmental influences [6], and even lifestyle factors [7]. Emerging epidemiological findings and randomized controlled trials (RCT) in recent decades strongly suggest that diet may play a pivotal role in not only triggering and exacerbating AD but also in its effective management [8][9][10][11][12]. Therefore, research focusing on dietary interventions in AD is essential for advancing treatment strategies, refining our understanding of how diet impacts symptom control and trigger reduction, and ultimately improving the quality of life for individuals with AD.…”

Section: Introductionmentioning

confidence: 99%

Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis

Lim,

Liu,

Chew

2024

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

Background: This scoping review aims to critically assess gaps in the current literature on atopic dermatitis (AD) by evaluating the overall effectiveness of dietary interventions. Through a comprehensive analysis that follows the Preferred Reporting Item for Systematic Review and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines, we conducted a thorough search on the Web of Science database in May 2023 using specific search strategies to identify all relevant studies on the research topic. Summary: A total of 104 full-text articles were included for review. Our synthesis identified seven notable categories of dietary interventions for AD, showcasing the diversity of interventions utilized. This includes vitamin supplementation, probiotic and prebiotic supplementation, dietary fat, biological compounds, foods from natural sources, major nutrients, and diet-related approaches. Further analyses stratified by targeted populations revealed a predominant focus on pediatrics, particularly in probiotic supplementation, and on adults, with an emphasis on vitamin D and E supplementation. Key Messages: Despite most dietary interventions demonstrating overall effectiveness in improving AD severity and its subjective symptoms, several significant gaps were identified. There was a scarcity of studies on adults and whole-diet interventions, a prevalence of short-term interventions, heterogeneity in study outcomes, designs, and population, occasional disparity between statistical significance and clinical relevance, and a lack of a comprehensive multidisciplinary approach. Nonetheless, these findings offer valuable insights for future AD research, guiding additional evidence-driven dietary interventions and informing healthcare professionals, researchers, and individuals, advancing both understanding and management of AD.

show abstract