Dietary Protein, Cortisol and Fetal Growth

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The evolution in detail of the N retention during gestation was studied, dividing it in short periods of time, and how that retention affects Longissimus dorsi muscle. Simultaneously, the same study in pregnant rats treated with hydrocortisone acetate was done. During gestation N balance maintains high values that tend to increase at days 18 to 21. The greatest metabolic utilization of the N dietary corresponds to this period in which the percentage of the N retained in relation to the N absorbed is markedly higher than in previous days of gestation. In spite of the excellent quality and adequate concentration of protein in the diet, the administration of 4 mg/100 g weight and day of hydrocortisone acetate maintains the pregnant rat in a negative balance until day 18, as a consequence of the decrease in food intake and faecal and urinary N losses. From day 18 to day 21 of gestation the balance of N increases and the metabolic utilization of the dietary N is similar between pregnant rats injected with NaCl 0.9% and pregnant rats injected with hydrocortisone acetate. The Longissimus dorsi normal growth pattern (in relation to weight and N content) in young adult rats is not modified by gestation. The catabolic effects of hydrocortisone acetate on Longissimus dorsi muscle in pregnant rats can be observed from day 9 of treatment. The longer the treatment the higher the effect is.

Section: Control Group Balancementioning

confidence: 52%

Influence of hydrocortisone acetate of the Longissimus dorsi muscle during gestation of rats

López-Jurado

Aranda

Montellano

et al. 1987

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“…The treatment of glucocorticoids in rats provokes a reduction in body weight as a result of the reduction of protein content [9,14,191, thus increasing urinary excretion of nitrogen and giving rise to a negative balance of the latter [4, 5, 81. This effect is dependent on the duration of treatment [20] and on the dose administered [2, 181. The glucocorticoids activate the protein catabolism in the majority of the peripheric tissues 119, 211.…”

Section: N H -C H -C H -C O -N H -C H~~ Nh-coon Imentioning

confidence: 99%

Influence of an inhibitor of monoaminooxidase (nialamide) on the absorption and retention of nitrogen in adult rats

Barrionuevo

Reche

Campos

et al. 1987

A study was made on adult rats (170 g) of the effect of nialamide (20 mg/100 g of diet), an inhibitor of monoaminooxidase, administered for 15 or 30 days (short or long-term, respectively), with food intake controlled (pair fed), on the absorption and retention of nitrogen, and on the nitrogen content in the liver, the gastronemio and longissimus dorsi muscles and in the small intestine. Nialamide administered for a time which can be considered prolonged (30 days) negatively affects absorption of alimentary protein, while metabolic utilization is reduced when the drug is administered both in the short and the long term. Proteic catabolism is less marked in male rats, due to the hormonal anabolizant situation in this sex. Nitrogen content under the effect of nialamide showed no significant variation in the gastronemio muscle or in the small intestine. There is a clear reduction in the longissimus dorsi muscle and an increase in the liver of those animals of both sexes treated with the drug, with the exception of male rats given nialamide in the long term.

Influence of gestation and hydrocortisone‐acetate treatment on the nutritive utilization of protein

Frías

Llopis

Montellano

et al. 1985

The effect of pregnancy and of cortisol on the digestive and metabolic utilization of protein in Wistar rats was studied. The cortisol is i.m. administered during 21 days in a pharmacological dose (4 mg/100 g weight per day) to female Wistar rats.Pregnacy is observed to increase and cortisol to decrease significantly the food intake (g dry matter/rat per day); the intake of nitrogen follows the same pattern.Pregnancy significantly increases the weight of both groups: pregnant rats as comparison to non-pregnant rats saline injected and pregnant rats cortisol-treated in relation to the animals pregnant but not hormonetreated. The increase being greater in the last 5 days of pregnancy. Cortisol in the pregnant and non pregnant rats considerably reduces the weight.The protein absorption is unaltered by pregnancy but is diminished by the effect of cortisol. Pregnancy increases the balance of nitrogen in both sets of rats; the increase being significantly greater in the last period of pregnancy. When administered to non pregnant rats, cortisol produces a negative balance of nitrogen. The protein of good quality (casein + 5 yo DL-methionine at a level of 12%) partially equalizes the negative effect of cortisol in spite of the long treatment and high doses used.