2008
DOI: 10.1038/sj.ki.5002647
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Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors

Abstract: Dietary casein promotes a progressive decline in the glomerular filtration rate (GFR) of remnant kidneys associated with metabolic acidosis and an endothelin-mediated increase in renal acidification. We tested whether diets that affect the acid-base status contributes to the decline of GFR through endothelin receptors in rats with a remnant kidney. Rats on a casein diet had metabolic acidosis at baseline and developed a progressive decline in GFR after renal mass reduction. Dietary sodium bicarbonate but not s… Show more

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Cited by 133 publications
(158 citation statements)
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“…The magnitude of this effect is also sufficient to override a simultaneous increase in extrarenal endogenous acid production. This observation contrasts with the results in rats where bosentan elicited a decrease in extrarenal acid production, a finding which, in itself, might explain the bosentan-induced decrease in distal acidification in that species (10,23). The reason(s) for this discrepancy between species is (are) not apparent.…”
Section: Discussioncontrasting
confidence: 55%
“…The magnitude of this effect is also sufficient to override a simultaneous increase in extrarenal endogenous acid production. This observation contrasts with the results in rats where bosentan elicited a decrease in extrarenal acid production, a finding which, in itself, might explain the bosentan-induced decrease in distal acidification in that species (10,23). The reason(s) for this discrepancy between species is (are) not apparent.…”
Section: Discussioncontrasting
confidence: 55%
“…Although some observations pointed to a beneficial effect of acidosis in experimental renal disease in rodents, 28,32,33 the bulk of observations indicate that alkali treatment has beneficial and acidosis exacerbatory effects in experimental CKD. [34][35][36][37] Moreover, clinical studies in humans demonstrate that acidosis accelerates and alkali treatment retards the progression of CKD. 34,39,[74][75][76] Along those lines, decreased bicarbonate concentrations are associated with decline of eGFR in community-living older persons.…”
Section: Discussionmentioning
confidence: 99%
“…38 Moreover, administration of alkali retards the progression of CKD in rodents. [34][35][36][37] In humans with CKD, acidosis is associated with worse kidney function, whereas the administration of bicarbonate, as shown in several studies, is associated with the slowing of progressive kidney disease. 37,39 Acidosis can be induced by dietary NH 4 Cl.…”
mentioning
confidence: 99%
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“…In previous studies, MA was found to activate a series of regulatory mechanisms to compensate for disordered acid-base balance, including complement activation, 30 endothelin production, and activation of the renin-angiotensin system. [31][32][33] This subsequently induced additional kidney damage. However, in contrast with clinical consequences such as the development of a catabolic state, 34 development or exacerbation of bone disease, 35 and deterioration of kidney function, 36 the decisive mechanism by which MA induces cellular dysfunction was largely unknown.…”
Section: Discussionmentioning
confidence: 99%