Dietary Protein, Aryl Hydrocarbon Hydroxylase and Chemical Carcinogenesis in Rats

Clinton, Steven K.; Truex, C. R.; Visek, Willard J.

doi:10.1093/jn/109.1.55

Cited by 40 publications

(3 citation statements)

References 27 publications

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“…The lack of a characteristic signal sequence for secretion, and the low expression ofFGF -2 receptors, raised doubts about its role as a major, direct acting angiogenic growth factor (149). Nevertheless, elevated levels of soluble FGF -2 have been detected in the serum and urine of many cancer patients, and FG F-2 has been shown to be a potent inducer of angiogenesis in a variety of experimental systems.…”

Section: Discussionmentioning

confidence: 99%

“…Dietary protein can increase, decrease, or have no effect on tumorigenesis in various tumor models, suggesting that protein may exert very specific mechanisms of action that are unique to each target tissue and initiating agent (42,(147)(148)(149).…”

Section: Dietary Protein and Amino Acidsmentioning

confidence: 99%

“…There it can bind FGF-2 molecules that are inactive because of their immobilization within the ECM. The displaced (soluble), and now biologically active FGF-2 molecules are free to mediate various functions, such as angiogenesis (149). In other words, secretion of FGF-BP by tumors may flip the angiogenic switch during tumor progression.…”

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confidence: 99%

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Antiangiogenic Agents in Cancer Therapy

Teicher¹

1999

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Section: Discussionmentioning

confidence: 99%

Section: Dietary Protein and Amino Acidsmentioning

confidence: 99%

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Antiangiogenic Agents in Cancer Therapy

Teicher¹

1999

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Diet and nutrition research

Kritchevsky¹

1988

Cancer

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The interest in nutrition and cancer, which was high in the 1940s and 1950s, was rekindled in the 1970s and is now more intense than ever. There has been considerable experimental work on dietary fat, but delineation of the precise role(s) of the essential fatty acids is still lacking. There have been few studies on protein or carbohydrate effects and only Visek has adequately addressed the important area of nutrient interactions. More work is needed in the fiber field with regard to the influences of short chain fatty acids, and the standardization of protocols is needed to make the various findings comparable. Currently, fiber data have been accrued using rats of different strains and gender, commercial and semipurified diets, a variety of colon carcinogens, and different routes of administration. The effects of energy restriction (in the literature since 1909) have not been widely studied as to mechanism and influence of energy expenditure (i.e., exercise) and merit more attention.

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Nutrition, body size, and breast cancer

Micozzi

1985

Am. J. Phys. Anthropol.

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Human epidemiologic and animal experimental evidence has suggested that excess intake of macronutrients (total calories, protein, fat) and deficient intake of micronutrients (p carotene, selenium) may be associated with increased incidence and decreased survival of breast cancer in women. The overall pattern of evidence, including migrant studies, has further suggested that dietary patterns in early life may be important to the long-term risk of breast cancer. Since cancer is currently thought to be a multistage process with a long latent period, early nutritional patterns which influence childhood growth and development may also influence the adult risk of cancer. Nutrition-mediated factors which may be associated with breast cancer risk include both anthropometric and reproductive variables. Enduring indicators of growth which can be measured in adults (e.g., stature, sitting height, frame size, lean body mass) may be reflective of early nutritional patterns which place women at increased risk of breast cancer. Anthropometric variables which may be related to adult nutritional patterns (e.g., absolute and relative fatness) are also associated with the risk of cancer in defined groups of women. Anthropometry may aid in the study of the relationship between breast cancer and the timing of nutritional excess, growth, menarche, and other risk factors. Other nutrition-related variables which may be associated with breast cancer include breast secretory activity, bowel function, and lactose tolerance. Recognition of the relationships among nutrition, body size, and breast cancer raises a new context for consideration of the adaptiveness of body size in human populations.Breast cancer, Anthropometry, Growth, Nutrition, MenThis review presents an explanatory model for the worldwide distribution of breast cancer, providing evidence for the role of nutrition and body size as risk factors for breast cancer. Evidence is provided in the context of nutritional, nutrition-mediated, and nutrition-related factors.Breast cancer has historically been the most frequent cancer in women and the leading cause of cancer death in women in the United States. The precise etiology of breast cancer is less well understood than that of many other cancers, and specific major risk factors have been difficult to identify. Kelsey (1979) has summarized the currently considered risk factors associated with breast cancer in humans. A few risk factors for breast cancer are associated with significant relative risks (magnitude of risk differential greater than 4.0), including increasing age, history of cancer in the opposite breast, history of bilateral premenopausal breast cancer in a firstdegree relative, and residence from an early age in North America or Northern Europe (as compared to Africa or Asia). Other risk factors are associated with small but significant relative risks (magnitude of risk differentials between 1.0 and 3.9). These include early age at menarche, late age at birth of first child, late age at menopause, single mar...

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Dietary Protein, Aryl Hydrocarbon Hydroxylase and Chemical Carcinogenesis in Rats

Cited by 40 publications

References 27 publications

Antiangiogenic Agents in Cancer Therapy

Antiangiogenic Agents in Cancer Therapy

Diet and nutrition research

Nutrition, body size, and breast cancer

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