Dietary protein and fatty acid composition of liver lipids in the rat

Sjöblom, Linnéa; Eklúnd, Anders

doi:10.1016/0005-2760(90)90302-e

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…Sweden) and 58% com starch. The use of olive oil and cholesterol is in agreement with our previous studies concerning di etary effects on the plasma lipid pattern [2] and hepatic fatty acid composition [6] in the present rat model.…”

Section: Feeding Experimentssupporting

confidence: 80%

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Comparison of Dietary Casein and Soybean Protein Effects on Plasma Lipid and Gastrin Levels, Hepatic Δ<sup>6-</sup>Desaturase Activity and Coronary Arteriosclerosis in Male Sprague-Dawley Rats

Lindholm

Sjöblom²,

Nordborg

et al. 1993

Ann Nutr Metab

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An increased concentration of gastrin was observed in plasma of male Sprague-Dawley strain rats fed on soybean protein diet for a 9-month period, compared with rats fed on casein diet. Both diets contained 0.5% (w/w) cholesterol. Protein-dependent differences were also observed in the fatty acid pattern of hepatic phospholipids, hepatic Δ⁶-desaturase activity, and plasma cholesterol. No signs of arteriosclerosis were observed in the aortas. Sixty percent of the hearts showed various degrees of lipid staining in coronary arterial branches of different sizes. Despite a large difference in plasma cholesterol level, there was no quantitative or qualitative difference between groups in the occurrence of coronary lipid staining.

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Section: Feeding Experimentssupporting

confidence: 80%

“…The statistical significance of differences between groups was evaluated by unpaired Student's t test: * p < 0.01. ** p < 0.001. isolated by thin layer chromatography, as described earlier [6]. The fatty acid composition of the lipid classes in the hcpatocyte microsomes was determined by gas-liquid chromatography [4],…”

Section: Fatty Acid a Nalysismentioning

confidence: 99%

Comparison of Dietary Casein and Soybean Protein Effects on Plasma Lipid and Gastrin Levels, Hepatic Δ<sup>6-</sup>Desaturase Activity and Coronary Arteriosclerosis in Male Sprague-Dawley Rats

Lindholm

Sjöblom²,

Nordborg

et al. 1993

Ann Nutr Metab

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“…On the 199 Storage and transport of fatty acids other hand, the reported amount of arachidonic acid/linoleic acid of phospholipids in rats who were fed the diet supplemented with cholesterol (CO, CS, CPO, CPS) was reduced as compared to the rats who were fed diets without cholesterol (data not published). These results are in agreement with those of Sjoblom and Eklund, (1990), which showed that the protein source affects the composition of the fatty acids of the phospholipids of the liver in rats subjected to 20 per cent casein or soy protein, combined with 10 per cent olive oil and supplemented with 0.5 per cent cholesterol. It is therefore interesting to determine whether there is a relationship between fatty acids in liver lipids and changes in the levels of lipids in the serum.…”

supporting

confidence: 94%

Olive or salmon oils affect differently the storage and transport of fatty acids by VLDL in hypercholesterolemic rats fed different proteins

Bouderbala

Bouchenak

2016

Nutrition &Amp; Food Science

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Purpose – The purpose of this study is to compare the effect of olive or salmon oil on the hepatic storage and transport of fatty acids by very-low-density lipoproteins (VLDL). Design/methodology/approach – In all, 24 male Wistar rats (80 ± 5 g) were fed a 0.5 per cent cholesterol-enriched diet with either 20 per cent casein (C) or chickpea (CP) proteins with 10 per cent olive (O) or salmon (S) oil for 28 days. Findings – In VLDL-triacyglycerols fatty acids, oleic acid content was higher in CPS as compared to that in CS or CPO and lower in CS and CPO than that in CO; linoleic acid content was higher in all groups; arachidonic acid content was higher in CS and CPO as compared to that in CO. In the liver, TG fatty acids content was lower in CPO or CPS as compared to that in CO or CS; oleic and arachidonic acid contents were lower in CPS than that in CPO; linoleic acid content was lower in CS, CPS and CPO than that in CO, CPO and CO. In liver, phospholipid fatty acid, oleic and arachidonic acid contents were lower in CPS than that in CS; oleic, linoleic and arachidonic acid contents were lower in CPO compared to that in CO. In liver, cholesteryl esters fatty acids, oleic, linoleic and arachidonic acids contents were higher in CPS as compared to that in CS; oleic, linoleic and arachidonic acid contents were lower in CS as compared to that in CO; linoleic and arachidonic acid contents were lower in CPS than that in CPO. Originality/value – A cholesterol-enriched diet containing casein or chickpea proteins combined with olive or salmon oil affects the hepatic storage and transport of polyunsaturated and monounsaturated fatty acids by VLDL.

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“…At termination of experiments, cells were rinsed with the heparin solution and cell lipids extracted as described above. Lipid extracts were separated in polar and neutral lipid classes by high performance thin layer chromatography [ 20 ]. Triglyceride fractions were extracted from silica with ethanol and analyzed by liquid scintillation counting.…”

Section: Methodsmentioning

confidence: 99%

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

2008

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Background: Pro-inflammatory cytokines can affect intracellular lipid metabolism. A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1β (IL-1β) reduces intracellular cholesterol levels in fibroblasts. Levels of the pro-inflammatory cytokines IL-1β and tumour necrosis factor-α (TNF-α) are up-regulated at sites of formation of atherosclerotic plaques. Plaque formation is though to begin with infiltration of monocytes to the intimal layer of the vascular wall, followed by differentiation to macrophages and macrophage uptake of modified lipoproteins, resulting in accumulation of intracellular lipids. The lipid-filled cells are referred to as macrophage foam cells, a key feature of atherosclerotic plaques. We have investigated the effects of IL-1β and TNF-α on macrophage foam cells in order to assess whether presence of the pro-inflammatory cytokines improves or aggravates macrophage foam cell formation by affecting lipid accumulation and lipid turn-over in the cells.

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Dietary protein and fatty acid composition of liver lipids in the rat

Cited by 13 publications

References 19 publications

Comparison of Dietary Casein and Soybean Protein Effects on Plasma Lipid and Gastrin Levels, Hepatic Δ<sup>6-</sup>Desaturase Activity and Coronary Arteriosclerosis in Male Sprague-Dawley Rats

Comparison of Dietary Casein and Soybean Protein Effects on Plasma Lipid and Gastrin Levels, Hepatic Δ<sup>6-</sup>Desaturase Activity and Coronary Arteriosclerosis in Male Sprague-Dawley Rats

Olive or salmon oils affect differently the storage and transport of fatty acids by VLDL in hypercholesterolemic rats fed different proteins

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

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Dietary protein and fatty acid composition of liver lipids in the rat

Cited by 13 publications

References 19 publications

Comparison of Dietary Casein and Soybean Protein Effects on Plasma Lipid and Gastrin Levels, Hepatic &Delta;<sup>6-</sup>Desaturase Activity and Coronary Arteriosclerosis in Male Sprague-Dawley Rats

Comparison of Dietary Casein and Soybean Protein Effects on Plasma Lipid and Gastrin Levels, Hepatic &Delta;<sup>6-</sup>Desaturase Activity and Coronary Arteriosclerosis in Male Sprague-Dawley Rats

Olive or salmon oils affect differently the storage and transport of fatty acids by VLDL in hypercholesterolemic rats fed different proteins

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

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Comparison of Dietary Casein and Soybean Protein Effects on Plasma Lipid and Gastrin Levels, Hepatic Δ<sup>6-</sup>Desaturase Activity and Coronary Arteriosclerosis in Male Sprague-Dawley Rats

Comparison of Dietary Casein and Soybean Protein Effects on Plasma Lipid and Gastrin Levels, Hepatic Δ<sup>6-</sup>Desaturase Activity and Coronary Arteriosclerosis in Male Sprague-Dawley Rats