“…For instance, chronic metabolic acidosis, consequent of a high-protein diet, was proposed by some authors as a risk factor for osteoporosis or bone fractures due to the increase in urinary calcium excretion resulting from the metabolic acidity of protein 5257 metabolism (Barzel and Massey, 1998;Bushinsky, 2001;Arnett, 2008). However, this effect on promoting bone mineral loss was negated by others (Bonjour, 2005;Cao et al, 2011;Thorpe and Evans, 2011).…”