Dietary pomegranate peel improves milk quality of lactating ewes: Emphasis on milk fat globule membrane properties and antioxidative traits

Argov-Argaman, Nurit; Cohen-Zinder, Miri; Leibovich, H.; Yishay, M.; Eitam, Harel; Agmon, Rotem; Hadaya, Oren; Mesilati-Stahy, Ronit; Miron, J.; Shabtay, Ariel

doi:10.1016/j.foodchem.2019.125822

Cited by 18 publications

(12 citation statements)

References 40 publications

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“…In particular, enhanced lipid production was concomitant with increased diameter of intracellular lipid droplets (the milk fat globule precursors); casein secretion was elevated; lactose synthesis and secretion was enhanced, and mitochondrial activity was more resilient to pro-oxidant load, as expressed by antioxidant activity, coupling efficiency and spare respiration capacity. In farm animals, the utilization of exogenous antioxidants was studied in several aspects: improvement of milk components and quality for human health 29,30 , vascular homeostasis during prooxidant challenge 31 , incidence of mastitis 32 semen quality 33 , plasma redox status 34 and weight gain of bull calves 35 . However, no cellular mechanism was investigated for these production traits till now.…”

Section: Discussionmentioning

confidence: 99%

Pistacia lentiscus extract enhances mammary epithelial cells’ productivity by modulating their oxidative status

Hadaya

Bransi-Nicola

Shalev

et al. 2020

Sci Rep

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We assessed the potential of phenolic compounds from Pistacia lentiscus (lentisk) to enhance production of milk constituents in bovine mammary epithelial cells (MEC). MEC were exposed to 0 (control), 1 or 10 ppm of polyphenols from lentisk ethanolic extract (PLEE) for 24 h. PLEE were absorbed by the MEC plasma membrane, but also penetrated the cell to accumulate in and around the nucleus. PLEE increased triglyceride content in the cell and its secretion to the medium, and significantly increased intracellular lipid droplet diameter. Compared to control, PLEE increased dose-dependently the lactose synthesis, secretion of whey proteins, and contents of casein. To evaluate mitochondrial activity under pro-oxidant load, MEC were preincubated with PLEE and exposed for 2 h to H2O2. Exposure to H2O2 increased the proportion of cells with impaired mitochondrial membrane potential twofold in controls, but not in PLEE-pre-treated cells. Accordingly, proton leakage was markedly decreased by PLEE, and coupling efficiency between the respiratory chain and ATP production was significantly enhanced. Thus, lentisk polyphenols divert energy to production of milk fat, protein and lactose, with less energy directed to cellular damage control; alternatively, PLEE enables MEC to maintain energy and oxidative status under extreme metabolic rate required for milk production and secretion, and reduces the limitation on energy required to support production.

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Section: Discussionmentioning

confidence: 99%

Pistacia lentiscus extract enhances mammary epithelial cells’ productivity by modulating their oxidative status

Hadaya

Bransi-Nicola

Shalev

et al. 2020

Sci Rep

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“…A previous study suggested that the dietary addition of grape residue silage (containing high levels of phenolics and flavonoids) in the feed improved PUFA proportion, the PUFA to SFA ratio, and antioxidant capacity in the milk of dairy cows, which ultimately improved milk quality [ 43 ]. A recent finding also suggested that pomegranate peel addition, which contains high concentrations of polyphenols, can improve the milk antioxidant capacity of lactating ewes [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Yellow Wine Lees Supplementation on Milk Antioxidant Capacity and Hematological Parameters in Lactating Cows under Heat Stress

Yao

Jiang

Liu

et al. 2021

Animals

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Fifteen multiparous lactating Chinese Holstein dairy cows were used in a replicated 3 × 3 Latin Square Design to evaluate the effect of total mixed rations (TMR) containing unfermented and fermented yellow wine lees (YWL) on the oxidative status of heat-stressed lactating cows and the oxidative stability of the milk and milk fatty acids they produced. Cows were fed with three isonitrogenous and isocaloric diets as follows: (1) TMR containing 18% soybean meal, (2) TMR containing 11% unfermented YWL (UM), and (3) TMR containing 11% fermented YWL (FM). The rectal temperature (at 1300 h) and respiratory rate were higher in control cows than in cows fed UM or FM. Both types of YWL were greater in total phenolic and flavonoid contents, reducing power, and radical scavenging abilities than soybean meal. Cows fed UM or FM had higher blood neutrophil, white blood cell, and lymphocyte counts, as well as lower plasma malondialdehyde level, higher plasma superoxide dismutase, glutathione peroxidase, and 2,2-diphenyl-1-picryl-hydrazyl-hydrate levels, and higher total antioxidant capacity in the plasma than those fed control diet. The proportion of milk unsaturated fatty acids was higher and that of saturated fatty acids was lower in UM- and FM-fed animals than in the control animals. Milk from UM- and FM-fed cows had lower malondialdehyde content but higher 2,2-diphenyl-1-picryl-hydrazyl-hydrate content than the control cows. In conclusion, feeding TMR containing UM and FM to cows reduced both the oxidative stress in heat-stressed cows and improved the oxidative capacity of their milk.

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“…Milk samples were analyzed for their antioxidant capacity as previously reported by Argov-Argaman et al (2020) . Thawed milk samples (20 µL) were assayed by luminol-enhanced chemiluminescence assay ( Ginsburg, Sadovnic, Oron, & Kohen, 2004 ) for their reducing antioxidant potential.…”

Section: Methodsmentioning

confidence: 99%

Direct effects of phenolic compounds on the mammary gland: In vivo and ex vivo evidence

Hadaya

Landau

Muklada

et al. 2021

Food Chemistry: Molecular Sciences

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Dietary pomegranate peel improves milk quality of lactating ewes: Emphasis on milk fat globule membrane properties and antioxidative traits

Cited by 18 publications

References 40 publications

Pistacia lentiscus extract enhances mammary epithelial cells’ productivity by modulating their oxidative status

Pistacia lentiscus extract enhances mammary epithelial cells’ productivity by modulating their oxidative status

Effect of Yellow Wine Lees Supplementation on Milk Antioxidant Capacity and Hematological Parameters in Lactating Cows under Heat Stress

Direct effects of phenolic compounds on the mammary gland: In vivo and ex vivo evidence

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