Dietary polyunsaturated fatty acids intake modifies the positive association between serum total cholesterol and colorectal cancer risk: the Rotterdam Study

Muka, Taulant; Kraja, Bledar; Ruiter, Rikje; Keyser, Catherina Elisabeth de; Hofman, Albert; Stricker, Bruno H. Ch.; Jong, Jessica C. Kiefte-de; Franco, Oscar H.

doi:10.1136/jech-2015-206556

Cited by 14 publications

(13 citation statements)

References 43 publications

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“…Furthermore, the association between cognition and cancer was studied [42,43]. We have confirmed the positive association between a high baseline total cholesterol level and colorectal cancer (CRC) during follow-up, an association which was modified by dietary polyunsaturated fatty acids [35]. In individuals with a BMI below 25, a relatively high intake of glutamic acid was associated with a reduced risk of CRC [34].…”

Section: Main Findings In the Last 3 Yearsmentioning

confidence: 76%

“…Furthermore, cancer may be a determinant or relevant co-factor in other RSstudies [32]. With regard to etiology, research has been done on diet [33][34][35][36] or lifestyle such as smoking [37,38] as a risk factor, and laboratory assessments, for example, inflammatory markers in association with cancer [31,[39][40][41]. Furthermore, the association between cognition and cancer was studied [42,43].…”

Section: Main Findings In the Last 3 Yearsmentioning

confidence: 99%

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Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

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Section: Main Findings In the Last 3 Yearsmentioning

confidence: 76%

Section: Main Findings In the Last 3 Yearsmentioning

confidence: 99%

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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“…We showed that n-3 polyunsaturated fatty acids intake were associated with increased risk of colorectal cancer, but this association was modified by dietary fiber intake [ 112 ]. We did find that dietary polyunsaturated fat intake modified the association between total serum cholesterol levels and the risk of colorectal cancer [ 113 , 114 ]. We also studied whether dietary mineral intake were associated the risk of lung cancer and found that high dietary zinc and iron intake were associated with a reduced risk of lung cancer [ 115 ].…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

The Rotterdam Study: 2018 update on objectives, design and main results

et al. 2017

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The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

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“…46 In fact, lowering of total cholesterol levels has resulted in reducing the risk for colorectal cancer. 47 Likewise, reduced levels of LDL and LDL receptor demonstrate good prognosis for patients with small cell lung cancer, 48 and intratumor cholesteryl ester accumulation has been suggested as a potential biomarker for breast cancer detection. 49 Emerging evidence indicates the presence of higher lipid content within CSCs irrespective of cancer origin.…”

Section: Rewiring Of Lipid Metabolism In Cancer and Cscsmentioning

confidence: 99%

Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells

et al. 2019

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Emerging evidence in cancer metabolomics has identified reprogrammed metabolic pathways to be a major hallmark of cancer, among which deregulated lipid metabolism is a prominent field receiving increasing attention. Cancer stem cells (CSCs) comprise <0.1% of the tumor bulk and possess high self-renewal, tumor-initiating properties, and are responsible for therapeutic resistance, disease recurrence, and tumor metastasis. Hence, it is imperative to understand the metabolic rewiring occurring in CSCs, especially their lipid metabolism, on which there have been recent reports. CSCs rely highly upon lipid metabolism for maintaining their stemness properties and fulfilling their biomass and energy demands, ultimately leading to cancer growth and invasion. Hence, in this review we will shed light on the aberrant lipid metabolism that CSCs exploit to boost their survival, which comprises upregulation in de novo lipogenesis, lipid droplet synthesis, lipid desaturation, and β-oxidation. Furthermore, the metabolic regulators involved in the process, such as key lipogenic enzymes, are also highlighted. Finally, we also summarize the therapeutic strategies targeting the key regulators involved in CSCs' lipid metabolism, which thereby demonstrates the potential to develop powerful and novel therapeutics against the CSC lipid metabolome.

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Dietary polyunsaturated fatty acids intake modifies the positive association between serum total cholesterol and colorectal cancer risk: the Rotterdam Study

Abstract: Taken together, these findings suggest that high levels of serum total cholesterol increase CRC risk, but this risk may be reduced by high dietary PUFAs intake.

Cited by 14 publications

References 43 publications

Objectives, design and main findings until 2020 from the Rotterdam Study

Objectives, design and main findings until 2020 from the Rotterdam Study

The Rotterdam Study: 2018 update on objectives, design and main results

Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells

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