Dietary polyunsaturated fatty acids in the prevention of allergic inflammatory conditions: progress and perspectives

West, Christina; Videky, Diane; Prescott, Susan L.

doi:10.1111/j.1365-2222.2010.03565.x

Cited by 7 publications

(3 citation statements)

References 16 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They argued that n‐3 fatty acids reduce prostaglandin formation by competitive inhibition with n‐6 fatty acids (linoleic acid) and by inhibiting the action of cyclo‐oxygenase. More recent research indicates that the mechanisms are undoubtedly more complex [23, 24]. Yet, in the context of mechanisms underlying the protective role of farm milk it is interesting to note that cheese from cows fed on alpine pastures contains significantly more n‐3 fatty acids and a significantly lower n‐6 : n‐3 ratio compared with conventionally produced cheese [25], and that elevated n‐3 fatty acids in cow's milk results from feeding grass‐only diets compared with a silage‐concentrated diet [26].…”

Section: Fat and Fatty Acidsmentioning

confidence: 99%

Can farm milk consumption prevent allergic diseases?

Braun-Fahrländer

Mutius

2010

Clinical &Amp; Experimental Allergy

105

View full text Add to dashboard Cite

Cow's milk is an important part of human diet and a source of food allergy for some individuals. Medical guidance strongly discourages consumption of raw milk because of the known health risk associated with pathogenic bacteria present in unpasteurized milk. Despite these risks there is a growing body of epidemiological evidence suggesting that consumption of unprocessed cow's milk does not increase but rather decreases the risk of asthma, hay fever and atopic sensitisation. The article reviews the epidemiological literature and discusses components of unprocessed milk potentially responsible for this protection. It focuses on the role of bacteria in raw milk, the fatty acid profile, whey proteins and finally the role of allergens in milk. Although the epidemiological evidence consistently suggest a protective role of unprocessed cow's milk consumption on the development of asthma, hay fever and atopic sensitization the underlying mechanisms are not yet understood and the consumption of raw milk cannot be recommended as a preventive measure for allergic diseases.

show abstract

Section: Fat and Fatty Acidsmentioning

confidence: 99%

Can farm milk consumption prevent allergic diseases?

Braun-Fahrländer

Mutius

2010

Clinical &Amp; Experimental Allergy

105

View full text Add to dashboard Cite

show abstract

“…Diet and allergic disease: more on the fatty acid story. There continues to be considerable interest in the possible relationship between the intake of fatty acids and allergic disease [2]. Increased consumption of n‐6 polyunsaturated fatty acids (PUVA) through the production of arachidonic acid may have pro‐inflammatory consequences, as oppose to consumption of n‐3 PUVA which generate alternative long chain fatty acids such as eicosapentanoic acid, which inhibit AA production and are linked to the production of the anti‐inflammatory resolvins.…”

mentioning

confidence: 57%

The Editor takes a closer look at some of this month's articles

2011

Clin Experimental Allergy

View full text Add to dashboard Cite

The Editor takes a closer look at some of this month's articles Aspirin induced asthma: lipoxins versus leukotrienes. Aspirin intolerant asthma continues to be a fascinating, but poorly understood sub-phenotype of asthma. It is well established that there is an excess of sulphidopeptide leukotrienes in this condition with in particular increased amounts of urinary leukotriene E 4 (LTE 4 ). However the potential involvement of an anti-inflammatory class of eicosanoids, the lipoxins, has not been examined in any detail. Lipoxins are eicosanoids (mediators derived from arachidonic acid), that include lipoxin A 4 (LXA 4 ), B 4 (LXB 4 ) and the epi-lipoxins formed by non-enzymatic peroxidation of lipoxin. Lipoxins inhibit leucocyte function and are thought to play a role in the resolution of inflammation [1]. In this issue Yamaguchi and colleagues (pp. 1711-1718) have investigated the urinary concentrations of lipoxin A 4 , 15 epi-LXA 4 and LTE 4 in patients with aspirin intolerant (AIA) and tolerant asthma (ATA) as well as normal controls. Consistent with other studies they found LTE 4 concentrations to be higher in the AIA subjects. Overall in asthma they found urinary concentrations of 15 epi-LXA 4 to be higher than LXA 4. They found reduced amounts of 15 epi-LXA 4 in AIA, which was not related to disease severity, suggesting that AIA is associated with an imbalance between pro and anti-inflammatory eicosanoids. This paper adds to the growing body of evidence suggesting that lipoxins may have a role as therapeutic agents in asthma and related diseases.

show abstract

“…It has been hypothesised that the increased consumption of omega‐6 polyunsaturated fatty acid (n‐6 PUFA) from margarine and vegetable oils (which would favour production of potentially pro‐inflammatory arachidonic acid metabolites), compared to n‐3 PUFA from fish oils, might explain the increased prevalence of allergic disease over the last few decades. However the epidemiological data linking fatty acid consumption to allergic disease has so far been inconclusive and treatment with diets rich in fish oils disappointing [3]. In a large well characterised birth cohort where maternal fatty acid consumption was accurately measured, Notenboom and colleagues (pp 407–416) explored the relationship between the amount of n‐6 and n‐3 PUFA consumption in mothers on the development of allergic disease in their offspring at two years of age.…”

mentioning

confidence: 99%

The Editor takes a closer look at some of this month's articles

2011

Clinical &Amp; Experimental Allergy

View full text Add to dashboard Cite

The Editor takes a closer look at some of this month's articles Atopic dermatitis: new ideas on pathogenesis and treatment:Atopic dermatitis (AD) is a major cause of morbidity affecting up to 20% of children and 9% of adults. Although the latest evidence suggests the condition is due to a primary defect in the barrier function of the skin, atopy is clearly a major risk factor for expression of the disease. Three papers in this issue approaching the condition from different angles have shed new light on its pathogenesis and treatment.Cover illustration: Schematic diagram of the conventional beta2 adrenergic receptor signalling pathway and receptor trafficking upon activation by ligand binding with a beta-agonist, taken from the review by Chung et al (pp. 312-326).

show abstract

Dietary polyunsaturated fatty acids in the prevention of allergic inflammatory conditions: progress and perspectives

Abstract: Cite this as: C. E. West, D. J. Videky and S. L. Prescott, Clinical & Experimental Allergy, 2010 (40) 1113–1115.

Cited by 7 publications

References 16 publications

Can farm milk consumption prevent allergic diseases?

Can farm milk consumption prevent allergic diseases?

The Editor takes a closer look at some of this month's articles

The Editor takes a closer look at some of this month's articles

Contact Info

Product

Resources

About