Dietary polyunsaturated fatty acid supplementation of young post-pubertal dairy bulls alters the fatty acid composition of seminal plasma and spermatozoa but has no effect on semen volume or sperm quality

Byrne, C.J.; Fair, Seán; English, A.M.; Holden, S.A.; Dick, James R.; Lonergan, Patrick; Kenny, David A.

doi:10.1016/j.theriogenology.2016.12.014

Cited by 22 publications

(21 citation statements)

References 33 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, retaining the membrane flexibility of the sperm tail is crucial for the sperm movement. High level of PUFAs in the sperm membrane assures higher fluidity of sperm cells, hence increasing the kinetic traits of the sperm [56][57][58].…”

Section: Relevance Of Fatty Acid Metabolism In Spermatogenesismentioning

confidence: 99%

Relevance of Fatty Acids to Sperm Maturation and Quality

Collodel

Castellini

Lee

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Almost 50% of infertility cases are associated with human male infertility. The sperm membrane is a key structure influencing sperm morphology and function in normal and pathological conditions. The fatty acid profile determines the performance not only of sperm motility but also of acrosomal reaction and sperm-oocyte fusion. This review presents available knowledge on the role of fatty acid composition in human sperm and spermatogenesis and discusses the influence of dietary fatty acids on the sperm fatty acid profile. Recent studies in biological sciences and clinical researches in this field are also reported. The topic object of this review has potential application in medicine by identifying potential causes of infertility.

show abstract

Section: Relevance Of Fatty Acid Metabolism In Spermatogenesismentioning

confidence: 99%

Relevance of Fatty Acids to Sperm Maturation and Quality

Collodel

Castellini

Lee

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…It appears that DHA-enriched oils or the use of nutraceuticals have systematically improved the quality of fresh semen after several weeks, at least regarding the classical motility parameter [49–51]. When the fatty acid composition of sperm was assessed, an increase in n -3 fatty acids was observed after DHA-rich oil supplementation [51, 52], with at least in one of these studies, a parallel increase in n -3 fatty acid plasma concentrations. In frozen-thawed sperm, analyzed from the same bulls, the results were not always consistent, with some studies showing no improvement in sperm quality [49], others showing a positive effect on motility parameters [51], or the percentage of sperm with intact acrosome [52].…”

Section: Lipid Overload and Oxidative Stress: Links Consequencesmentioning

confidence: 99%

“…When the fatty acid composition of sperm was assessed, an increase in n -3 fatty acids was observed after DHA-rich oil supplementation [51, 52], with at least in one of these studies, a parallel increase in n -3 fatty acid plasma concentrations. In frozen-thawed sperm, analyzed from the same bulls, the results were not always consistent, with some studies showing no improvement in sperm quality [49], others showing a positive effect on motility parameters [51], or the percentage of sperm with intact acrosome [52]. A study reported that the lipid composition of sperm improved after the freeze-thaw procedure, with an increase in the proportion of n -3 PUFA in sperm from fish oil-supplemented bulls compared to control animals, in association with improved sperm quality assessed by viability, progressive motility, and morphology [50].…”

Section: Lipid Overload and Oxidative Stress: Links Consequencesmentioning

confidence: 99%

Dietary Cholesterol and Lipid Overload: Impact on Male Fertility

Saez

Drevet

2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Lipid metabolic disorders due to poor eating habits are on the rise in both developed and developing countries, with a negative impact of the “Western diet” on sperm count and quality. Dietary lipid imbalance can involve cholesterol, fatty acids, or both, under different pathophysiological conditions grouped under the term dyslipidemia. The general feature of dyslipidemia is the development of systemic oxidative stress, a well-known deleterious factor for the quality of male gametes and associated with infertility. Sperm are particularly rich in polyunsaturated fatty acids (PUFA), an important characteristic associated with normal sperm physiology and reproductive outcomes, but also targets of choice for oxidative thrust. This review focuses on the effects of dietary cholesterol or different fatty acid overload on sperm composition and function in both animals and humans. The links between oxidative stress induced by dyslipidemia and sperm dysfunction are then discussed, including possible preventive or therapeutic strategies to preserve gamete quality, longevity when stored in cryobanking, and male fertility.

show abstract

“…Dietary supplementation may also be an alternative, since the greater fragility of senior bull semen in cryopreservation and its susceptibility to oxidative stress may bring a new perspective on the use of PUFAs and/or inclusion of antioxidants in the diet of animals. Several studies have described that incorporation of PUFAs in the diet improves sperm quality in both fresh and frozen semen (Gürler et al, 2015;Selvaratnam et al, 2015;Khoshvaght et al, 2016;Van Tran et al, 2017) and that animals with lowquality semen may be major beneficiaries of this type of supplementation (Byrne et al, 2017).…”

Section: Tablementioning

confidence: 99%

Does lipid peroxidation and oxidative DNA damage differ in cryopreserved semen samples from young, adult and aged Nellore bulls?

Trevizan

Carreira

Carvalho

et al. 2018

Animal Reproduction Science

View full text Add to dashboard Cite

The aims of this study were to evaluate cryopreserved semen of Nellore bulls of different ages and verify whether sperm quality declines with advancing age and whether lipid peroxidation and DNA damage are involved in this process. For this purpose, 40 Nellore bulls were divided into three age groups: Young, aged 1.8-2 years (n = 9); Adult, aged 3.5-7.0 years (n = 19); and Seniors, aged 8.0-14.3 years (n = 12). Three ejaculates were collected from each bull, cryopreserved and evaluated for various parameters including membrane integrity, mitochondrial potential (FITC-PSA and JC1), lipid peroxidation (C-11BODIPY 581 / 591) and oxidative DNA damage (8OHdG) using flow cytometry. The thawed semen of senior bulls was characterized by a low percentage of motile sperm (33.7 ± 6.1%), higher damage to the plasma and acrosomal membrane (37.5 ± 9.8%), and low mitochondrial potential (29.1 ± 13.8%), as well as higher percentages of peroxidated cells (53.6 ± 12.2%) and DNA damage (44.1 ± 11.0%; P < 0.05). Lipid peroxidation was negatively correlated with motility (r = -0.35, P < 0.0002), average mitochondrial potential (r = -0.42; P < 0.0001) and showed a positive correlation with membrane injury and oxidative DNA damage (r = 039; P = 0.0003). Young bulls presented superior thawed sperm quality, possibly due to greater resistance to oxidative stress and, consequently, to cryopreservation. In conclusion, the sperm quality of bull semen declines with advancing age and is strongly associated with increased oxidative damage to both the plasma membrane and DNA.

show abstract

Dietary polyunsaturated fatty acid supplementation of young post-pubertal dairy bulls alters the fatty acid composition of seminal plasma and spermatozoa but has no effect on semen volume or sperm quality

Cited by 22 publications

References 33 publications

Relevance of Fatty Acids to Sperm Maturation and Quality

Relevance of Fatty Acids to Sperm Maturation and Quality

Dietary Cholesterol and Lipid Overload: Impact on Male Fertility

Does lipid peroxidation and oxidative DNA damage differ in cryopreserved semen samples from young, adult and aged Nellore bulls?

Contact Info

Product

Resources

About