Dietary polystyrene nanoplastics exposure alters hepatic glycolipid metabolism, triggering inflammatory responses and apoptosis in Monopterus albus

Zhu, Chenxi; Zhou, Wenzong; Han, Mingming; Yang, Ying; Li, Yiming; Jiang, Qichen; Lv, Weiwei

doi:10.1016/j.scitotenv.2023.164460

Cited by 18 publications

(7 citation statements)

References 57 publications

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“…Researches have demonstrated that the MAPK signaling pathway was activated by oxidative stress to trigger inflammation, apoptosis, autophagy, etc ( Kim and Choi, 2015 ). PS-NPs were shown to induce oxidative stress and activate the MAPK signaling pathway in Monopterus albus and Mus musculus spleen ( Tang et al, 2022 ; Zhu et al, 2023 ). ROS are considered an important physiological modulator of MAPK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae

Liu

Yang

2023

Front. Physiol.

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Nanoplastics (NPs), as a new type of pollutant with a size small than 1 μm, are ubiquitous and harmful to organisms. There has been an increasing amount of research concerning the effects of NPs on organisms over recent years, especially on aquatic animals. However, there is a limited study on the impact of NPs on mollusk cephalopods. In this research, Sepia esculenta, belonging to Cephalopoda, Coleoidea, Sepioidea, was selected to explore the effects caused by NPs exposure. The S. esculenta larvae were exposed to polystyrene NPs (PS-NPs) with diameter 50 nm (100 mg/L) for 4 h. The detection of oxidative stress biomarkers displayed an obvious increase in SOD (superoxide dismutase) activity and MDA (malondialdehyde) level. Then, RNA-Seq was performed to explore the oxidative stress response at mRNA level. The transcriptome analysis demonstrated that the expression of 2,570 genes was affected by PS-NPs. Besides, the signaling pathways of ribosome, ribosome biogenesis in eukaryotes, proteasome, and MAPK were enriched. This study not only provides novel references for understanding the mechanisms of oxidative stress response induced by NPs, but also reminds us to follow with interest the influence of acute exposure to NPs.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae

Liu

Yang

2023

Front. Physiol.

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“…Oxidative stress has been the most reported damage to a large ammount of aquatic species like algae [21,22,23], fish [24,25,26], daphnia [27,28], clams [29; 30], crayfish [31], sea snail [32], ciliates [33], molluscs [34]. Other effects that were observed as a result of microplastics were mutagenic [35] and carcinogenic [36,37] effects, endocrine disruption [24,38,39,40,41], changes in the feeding [42,43] and swimming [28,44,45,46,47,48] behaviour.…”

Section: Harmful Effects On Aquatic Organismsmentioning

confidence: 99%

The Harmful Effects of Microplastic Pollution on Aquatic Organisms

Yilmaz,

Emecan,

Elhag

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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In recent years, microplastics have been recognized as the most popular pollutants in marine and fresh waters. Plastic is one of the most used materials in all areas of our lives due to its cheap, light, and durable properties. Because they are used as main or auxiliary materials in almost all industries and branches of industry, the disappearance of plastics, which are in our lives, requires very long processes. Since petroleum-derived plastic wastes, which bacteria cannot consume directly, are decomposed by solar heat and radon, only the resulting compounds can be consumed by bacteria. For this reason, awareness-raising efforts to reduce plastic consumption in daily use all over the world have been accelerated. In parallel with this situation, research on microplastic pollution in both seas and inland waters is carried out intensively. Considering the current consumption habits of us humans, who are at the top of the food chain, the rates of microplastics we are exposed to are at a substantial level. The determination of the amount of microplastics contained in seafood consumed as the main protein source is of great importance in terms of public health and shows the necessity of further scientific research on this subject. The purpose of our study is to reveal the effects of microplastic pollution on aquatic organisms both in sea and inland waters by compiling studies on this subject and to draw attention to microplastic pollution in waters.

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“…MPs pollution mainly comes from secondary release after fragmentation and degradation of daily plastic products, chemical products, and medical products such as masks ( Hettiarachchi and Meegoda 2023 ; Kaur et al, 2023 ; Turner and Filella 2023 ). Some studies have pointed out the toxicity of polystyrene microplastics ( PS-MP ) to aquatic animals, such as the damage of 50 μm to the nervous system of goldfish larvae ( Yang et al, 2020 ), and the metabolic disorder of liver in monopterus albus caused by 0.1 μm PS-MPs ( Zhu et al, 2023 ). In mammals, mice neuroinflammation and parkinsonian lesions occurred after MPs exposure ( Yang et al, 2019 ; Lee et al, 2022 ), and the 5 μm size demonstrates disruption of the rat intestinal barrier, further attracting digestive disorders ( Huang et al, 2023b ).…”

Section: Introductionmentioning

confidence: 99%

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress

Guo,

Geng,

Zhang

et al. 2024

Poultry Science

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Dietary polystyrene nanoplastics exposure alters hepatic glycolipid metabolism, triggering inflammatory responses and apoptosis in Monopterus albus

Cited by 18 publications

References 57 publications

Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae

Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae

The Harmful Effects of Microplastic Pollution on Aquatic Organisms

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress

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