Dietary polysaccharides from guavira pomace, a co-product from the fruit pulp industry, display therapeutic application in gut disorders

Oliveira, Natália Mulinari Turin de; Luz, Bruna Barbosa da; Schneider, Vanessa Suzane; Filho, Humberto Barbosa da Costa; Sousa, Paulo Sérgio de Araújo; Werner, Maria Fernanda de Paula; Souza, Marcellus H.; Rocha, Jefferson Almeida; Nicolau, Lucas Antônio Duarte; Cordeiro, Lucimara M.C.; Maria-Ferreira, Daniele

doi:10.1016/j.foodres.2022.111291

Cited by 15 publications

(4 citation statements)

References 93 publications

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“…Imbalance in the intestinal microenvironment is one of the key factors in the development of intestinal inflammation in IBD. 17 There is a growing trend of studies showing the effects of probiotics, prebiotics, and postbiotics (inanimate microorganisms or preparations of their components that are beneficial for host health) 18 on the gut microbiota and their metabolic functions. 19,20…”

Section: Discussionmentioning

confidence: 99%

“…Food & Function IBD. 17 There is a growing trend of studies showing the effects of probiotics, prebiotics, and postbiotics (inanimate microorganisms or preparations of their components that are beneficial for host health) 18 on the gut microbiota and their metabolic functions. 19,20 A. muciniphila, as the next generation of beneficial microorganisms, is a live biological therapeutic product for the clinical fight against metabolic diseases such as obesity and diabetes.…”

Section: Papermentioning

confidence: 99%

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The effects of live and pasteurized Akkermansia muciniphila on DSS-induced ulcerative colitis, gut microbiota, and metabolomics in mice

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Section: Papermentioning

confidence: 99%

The effects of live and pasteurized Akkermansia muciniphila on DSS-induced ulcerative colitis, gut microbiota, and metabolomics in mice

et al. 2023

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“…O resíduo do processamento da sua polpa, formado por casca e semente, geralmente é subutilizado. Embora estudos mostrem o potencial dessa planta com atividade anti-inflamatória (Viscardi et al, 2017b), anti-hiperlipidêmica (Espindola et al, 2016), antibacteriana (Oliveira et al, 2016), fotoprotetora (Catelan et al, 2019), antiproliferativa (Alves et al, 2020;Campos et al, 2017) e para tratar distúrbios intestinais (Mulinari Turin de Oliveira et al, 2022), são necessárias mais pesquisas com a casca e a semente dos frutos a fim de investigar suas atividades biológicas e potencializar sua aplicação.…”

Section: Introductionunclassified

Teor de fenólicos, flavonoides e atividade antibacteriana em diferentes extratos vegetais e óleo essencial de casca e semente de Campomanesia adamantium

Correia,

Cardoso,

Bin

et al. 2023

OLEL

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A Campomanesia adamantium, ou guavira, é nativa do Cerrado brasileiro e cresce naturalmente em solos pobres e condições adversas. Essa planta apresenta propriedades antimicrobiana, antiinflamatória, antitumoral, antioxidante, entre outras. Dos frutos, a polpa é a parte mais utilizada, restando casca e semente. Esses resíduos contêm compostos bioativos e têm potencial biológico que muitas vezes é subestimado. O estudo investigou os extratos vegetais e o óleo essencial da casca e da semente do fruto da guavira em relação à influência do solvente, composição química, compostos fenólicos, flavonoides e atividade antibacteriana. Utilizou-se seis solventes: água destilada, metanol 50%, etanol 70%, acetona 70%, hexano e acetato de etila e o óleo essencial foi extraído por hidrodestilação (três e cinco horas). O metanol produziu o maior rendimento (49%) para a semente, enquanto o etanol foi mais eficaz (41%) na extração da casca. O tipo de solvente interferiu no perfil cromatográfico e nos outros parâmetros, onde a acetona extraiu mais compostos fenólicos (3197,9 e 2840,3 mg GAE/ 100 g) e flavonoides (203 e 809 mg QUE/ 100 g), em casca e semente respectivamente. Houve ação bactericida pelo extrato hexânico da casca (MIC: 2000 µg/mL) para Staphylococcus aureus e S. pyogenes, e pelo extrato com acetato de etila da semente (MIC: 2000 µg/mL) para S. pyogenes. Óleo essencial da casca apresentou efeito bactericida para Klebsiela sp. (MIC: 450 µg/mL). A pesquisa indica potencial biológico do resíduo desse fruto, que pode ser melhor esclarecido com estudos complementares que investiguem a atividade antibacteriana dos constituintes individuais.

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“…In recent years, polysaccharides have received wide attention owing to their unique physicochemical properties, functional characteristics, and biological activities, and are widely used in food, pharmaceutical, and cosmetic industries [ 11 ]. Numerous studies have shown that polysaccharides have excellent biological activities, such as anti-inflammatory [ 12 ], immunomodulatory [ 13 ], anti-tumor [ 14 ], antioxidant [ 15 ], and prebiotic activities [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Characteristics of Rehmannia glutinosa Polysaccharides Treated Using Different Decolorization Processes and Their Antioxidant Effects in Intestinal Epithelial Cells

Ren

Gao

et al. 2022

Foods

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Polysaccharide decolorization is a key determinant of polysaccharide structure. In this study, two purified Rehmannia glutinosa polysaccharides, RGP−1−A and RGP−2−A, were obtained after decolorization using the AB-8 macroporous resin and H2O2, respectively. RGP−1−A (molecular weight (Mw) = 18,964 Da) and RGP−2−A (Mw = 3305 Da) were acidic and neutral heteropolysaccharides, respectively, and were both polycrystalline in structure. FTIR analysis revealed that RGP−1−A was a sulfate polysaccharide, while RGP−2−A had no sulfate group. Experiments on IPEC-1 cells showed that RGPs alleviated oxidative stress by regulating the Nrf2/Keap1 pathway. These findings were confirmed by the upregulation of Nrf2, NQO1, and HO-1; the subsequent increase in the levels of antioxidant indicators (SOD, LDH, CAT, and MDA); and the restoration of mitochondrial membrane potential. Overall, the antioxidant capacity of RGP−1−A was significantly higher than that of RGP−2−A. These results suggest that RGPs may be a potential natural antioxidant and could be developed into functional foods.

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Dietary polysaccharides from guavira pomace, a co-product from the fruit pulp industry, display therapeutic application in gut disorders

Cited by 15 publications

References 93 publications

The effects of live and pasteurized Akkermansia muciniphila on DSS-induced ulcerative colitis, gut microbiota, and metabolomics in mice

The effects of live and pasteurized Akkermansia muciniphila on DSS-induced ulcerative colitis, gut microbiota, and metabolomics in mice

Teor de fenólicos, flavonoides e atividade antibacteriana em diferentes extratos vegetais e óleo essencial de casca e semente de Campomanesia adamantium

Structural Characteristics of Rehmannia glutinosa Polysaccharides Treated Using Different Decolorization Processes and Their Antioxidant Effects in Intestinal Epithelial Cells

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