Dietary polyphenols in lipid metabolism: A role of gut microbiome

Ma, Jie; Zheng, Yongmin; Tang, Wenjie; Yan, Wenxin; Nie, Houfu; Fang, Jun; Liu, Gang

doi:10.1016/j.aninu.2020.08.002

Cited by 45 publications

(31 citation statements)

References 93 publications

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“…The intestinal tract is the largest independent immune system in the body. It is continuously exposed to foreign antigens and the distinction between harmful and harmless antigens is necessary for the intestine to ensure an appropriate response to every antigen ( Weiner, 2000 ; Ma et al, 2020a ). The gut needs to produce a strong protective immune response to resist the invasion of pathogenic antigens, while similar reactions to harmless antigens such as dietary proteins or symbiotic microorganisms, may lead to chronic inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Roles of Macrophages in the Development and Treatment of Gut Inflammation

Han

Ding

Jiang

et al. 2021

Front. Cell Dev. Biol.

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108

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Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. The large number of macrophages in the intestinal tract, play a significant role in maintaining the homeostasis of microorganisms on the surface of the intestinal mucosa and in the continuous renewal of intestinal epithelial cells. They are not only responsible for innate immunity, but also participate in the development of intestinal inflammation. A clear understanding of the function of macrophages, as well as their role in pathogens and inflammatory response, will delineate the next steps in the treatment of intestinal inflammatory diseases. In this review, we discuss the origin and development of macrophages and their role in the intestinal inflammatory response or infection. In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper.

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Section: Introductionmentioning

confidence: 99%

Roles of Macrophages in the Development and Treatment of Gut Inflammation

Han

Ding

Jiang

et al. 2021

Front. Cell Dev. Biol.

Self Cite

108

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show abstract

“… 15 Consumptions of tea, vegetables and fruits that are rich in dietary polyphenols have also been found to be effective in improving blood lipid parameters. 16 Therefore, the issue as to whether blood lipids play a role in the effect of diet on T2DM is another question that we focused on in this study.…”

Section: Introductionmentioning

confidence: 99%

The Role of Changes in Cumulative Lipid Parameter Burden in the Pathogenesis of Type 2 Diabetes Mellitus: A Cohort Study of People Aged 35–65 Years in Rural China

Wang¹,

Xie²,

Zhang³

et al. 2022

DMSO

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Purpose The main purpose of this study was to examine the effect of the cumulative exposure of blood lipid parameters on type 2 diabetes mellitus (T2DM). Another purpose was to explore whether the cumulative burden of blood lipid parameters plays a certain role in the pathogenesis of diet affecting T2DM. Patients and Methods A total of 63 cases of diabetes occurred from 2017 to 2020, with an incidence density of 3.71 person-years. The dietary intake of the residents was obtained by using a dietary frequency questionnaire (FFQ). Cumulative lipid parameter burden was calculated according to the number of years (2016–2020) multiplied by total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG). A Cox proportional hazard model was used to estimate the effect of cumulative lipid burden on T2DM. A mediating analysis of accelerated failure time (AFT) was used to investigate the mediating effects of certain foods, the cumulative lipid parameter burden and T2DM. Results A higher cumulative TG load corresponded to a higher risk of T2DM onset ( P trend =0.021). After adjusting for covariates, the highest quartile cumulative TG burden had a 3.462 times higher risk of T2DM than that in the lowest quartile ( HR =3.462, 95% CI : 1.297–9.243). Moreover, a higher cumulative HDL load corresponded to a lower risk of T2DM onset ( P trend =0.006). After adjusting for covariates, the risk of T2DM was 0.314-fold lower in the highest quartile of cumulative HDL burden than that in the lowest quartile ( HR =0.314, 95% CI : 0.131–0.753). Cumulative TG burden partially mediated the association between red meat and T2DM. Conclusion The increase in cumulative HDL burden and the decrease in cumulative HDL burden are related to the incidence of T2DM. Cumulative TG burden was shown to play a partial mediating role in the pathogenesis of red meat and diabetes.

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“…Specific components of food, for example, ginseng or resveratrol from cabernet sauvignon grape extract, are considered to be healthy through microbial modifications ( 175 , 176 ). Generally, dietary polyphenols have an influence on lipid metabolism and related metabolic diseases through the prebiotic effect on the selection of beneficial bacteria.…”

Section: Effects Of Nutrition On Intestinal Permeability and The Gut ...mentioning

confidence: 99%

The Influence of Nutrition on Intestinal Permeability and the Microbiome in Health and Disease

et al. 2022

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The leakage of the intestinal barrier and the disruption of the gut microbiome are increasingly recognized as key factors in different pathophysiological conditions, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), chronic liver diseases, obesity, diabetes mellitus, types of cancer, and neuropsychiatric disorders. In this study, the mechanisms leading to dysbiosis and “leaky gut” are reviewed, and a short summary of the current knowledge regarding different diseases is provided. The simplest way to restore intestinal permeability and the microbiota could be ideal nutrition. Further therapeutic options are also available, such as the administration of probiotics or postbiotics or fecal microbiota transplantation.

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Dietary polyphenols in lipid metabolism: A role of gut microbiome

Cited by 45 publications

References 93 publications

Roles of Macrophages in the Development and Treatment of Gut Inflammation

Roles of Macrophages in the Development and Treatment of Gut Inflammation

The Role of Changes in Cumulative Lipid Parameter Burden in the Pathogenesis of Type 2 Diabetes Mellitus: A Cohort Study of People Aged 35–65 Years in Rural China

The Influence of Nutrition on Intestinal Permeability and the Microbiome in Health and Disease

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