Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study

Grosso, Giuseppe; Stepaniak, Urszula; Micek, Agnieszka; Stefler, Dénes; Bobák, Martin; Pająk, Andrzej

doi:10.1007/s00394-016-1187-z

Cited by 116 publications

(84 citation statements)

References 60 publications

(55 reference statements)

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“…Grosso et al published a cohort study in 2016 on another 10,000 Polish subjects, demonstrating an interesting inverse association between polyphenols and metabolic syndrome, which is particularly evident in individuals with the biggest intake of these [22]. …”

Section: Cardiovascular Benefits Of Citrus Flavanones—epidemiologimentioning

confidence: 99%

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

2017

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Background- Cardiovascular diseases, including myocardial infarction, dyslipidaemia and coronary artery pathology, are a major cause of illness and death in Western countries. Therefore, identifying effective therapeutic approaches and their cellular signalling pathways is a challenging goal for medicine. In this regard, several epidemiological studies demonstrate a relationship between the intake of flavonoid-rich foods and the reduction of cardiovascular risk factors and mortality. In particular, flavonoids present in citrus fruits, such as oranges, bergamots, lemons and grapefruit (95% from flavanones), are emerging for their considerable nutraceutical value. Methods- In this review an examination of literature was performed while considering both epidemiological, clinical and pre-clinical evidence supporting the beneficial role of the flavanone class. We evaluated studies in which citrus fruit juices or single flavanone administration and cardiovascular risk factors were analysed; to identify these studies, an electronic search was conducted in PUBMED for papers fulfilling these criteria and written in English. Results- In addition to epidemiological evidence and clinical studies demonstrating that fruits in the Citrus genus significantly reduce the incidence of cardiovascular disease risk, pre-clinical investigations highlight cellular and subcellular targets that are responsible for these beneficial effects. There has been special attention on evaluating intracellular pathways involved in direct cardiovascular and cardiometabolic effects mediated by naringenin, hesperetin and eriodictyol or their glycosylated derivatives. Conclusions- Although some mechanisms of action remain unclear and bioavailability problems remain to be solved, the current evidence supports the use of a nutraceutical approach with citrus fruits to prevent and cure several aspects of cardiovascular disease.

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Section: Cardiovascular Benefits Of Citrus Flavanones—epidemiologimentioning

confidence: 99%

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

2017

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“…Daily consumption of (poly)phenols has been related to reduction of inflammation, hypertension, risk of cardiovascular, metabolic, neurodegenerative diseases, and cancer [18,19,20,21,22]. An essential part of the scientific research in vivo is represented by the investigation of the absorption, metabolism and bioavailability of (poly)phenolic compounds after human intake.…”

Section: Introductionmentioning

confidence: 99%

Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries

et al. 2017

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The market of plant-based nutraceuticals and food supplements is continuously growing due to the increased consumer demand. The introduction of new products with relevant nutritional characteristics represents a new way of providing bioactive compounds and (poly)phenols to consumers, becoming a strategy to ideally guarantee the health benefits attributed to plant foodstuffs and allowing the increase of daily bioactive compound intake. A paramount step in the study of nutraceuticals is the evaluation of the bioavailability and metabolism of their putatively active components. Therefore, the aim of the present study was to investigate the absorption profile of the (poly)phenolic compounds contained in three different plant-based food supplements, made of 36 different plant matrices, which were consumed by 20 subjects in an open one-arm study design. Blood samples were collected at baseline and 1, 2, 5, and 10 h after capsule intake. Twenty quantifiable metabolites deriving from different (poly)phenolic compounds were identified. Results showed that the consumption of the three capsules allowed the effective absorption of several (poly)phenolic compounds and metabolites appearing at different times in plasma, thereby indicating different absorption profiles. The capsules thus ensured potential health-promoting molecules to be potentially available to target tissues and organs.

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“…72 HCA intake was also associated with lower odds of depression in an Italian cohort, although not in a linear dependence on concentration, 73 and with lower odds of developing metabolic syndrome in a Polish cohort. 74 Other two studies conducted in Iran showed no association between phenolic acid intake and metabolic syndrome; 75,76 however, the reported intake of phenolic acids in the Iranian studies was much lower than that in the Polish study. 74 A reduced risk of diabetes in elderly persons at high risk of CVD was associated with a high intake of total polyphenols in a Spanish cohort.…”

Section: Hydroxycinnamic Acids and Disease Risk In Epidemiological Stmentioning

confidence: 92%

“…flavonoids, have a much longer research history in terms of epidemiological evidence of their health effects. [64][65][66] Regarding phenolic acids, recent cohort studies ( Table 2) have focused mainly on cardiovascular disease (CVD), [67][68][69] hypertension, [70][71][72] depression, 73 metabolic syndrome, [74][75][76] diabetes, 77 and colorectal cancer. 78 A higher intake of polyphenols was associated with a statistically significant decrease in CVD risk in two studies from France and Spain, 67,69 whereas no association was found in the third.…”

Section: Hydroxycinnamic Acids and Disease Risk In Epidemiological Stmentioning

confidence: 99%

Hydroxycinnamic acids and human health: recent advances

Coman

Vodnar

2019

J Sci Food Agric

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There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter‐individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre‐clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry

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Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study

Cited by 116 publications

References 60 publications

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries

Hydroxycinnamic acids and human health: recent advances

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