Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits

Polichetti, Elisabeth; Janisson, Anne; Porte, P. Lechêne de la; Portugal, Henri; Léonardi, Jeannie; Luna, Antonia; Droitte, Philippe La; Chanussot, F.

doi:10.1016/s0024-3205(00)00840-7

Cited by 45 publications

(15 citation statements)

References 32 publications

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“…Previous studies have shown that fish oil suppresses the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase, a rate-limiting enzyme of cholesterol synthesis [47]. Additionally, it has been reported that dietary phosphatidylcholine decreases hepatic cholesterol levels through the enhancement of the secretion of bile cholesterol in hypercholesterolemic rabbits [48]. Further studies are necessary to clarify the effect of dietary EPA-PL on the synthesis and excretion of cholesterol in the liver.…”

Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice

et al. 2013

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BackgroundOver the past two decades, a striking increase in the number of people with metabolic syndrome (MS) has taken place worldwide. With the elevated risk of not only diabetes but also cardiovascular morbidity and mortality, there is urgent need for strategies to prevent this emerging global epidemic. The present study was undertaken to investigate the effects of dietary eicosapentaenoic acid-enriched phospholipid (EPA-PL) on metabolic disorders.MethodsMale C57BL/6J mice (n = 7) were fed one of the following 4 diets for a period of 4 weeks: 1) a modified AIN-96G diet with 5% corn oil (control diet); 2) a high fat (20%, wt/wt) and high fructose (20%, wt/wt) diet (HF diet); 3) the HF diet containing 1% SOY-PL (SOY-PL diet); 4) the HF diet containing 1% EPA-PL (EPA-PL diet). The oral glucose tolerance test was performed. Plasma TG, TC, glucose, NEFA, insulin, leptin, adiponectin, TNF-α and IL-6 levels were assessed. In addition, hepatic lipid levels, lipogenic, and lipidolytic enzyme activities and gene expressions were evaluated.ResultsBoth EPA-PL and SOY-PL significantly inhibited body weight gain and white adipose tissue accumulation, alleviated glucose intolerance, and lowered both serum fasting glucose and NEFA levels substantially. Only EPA-PL significantly reduced serum TNF-α and IL-6 levels, and increased serum adiponectin level. EPA-PL was more effective in reducing hepatic and serum TG and TC levels than SOY-PL. Both EPA-PL and SOY-PL reduced the activities of hepatic lipogenic enzymes, such as FAS and G6PDH, but only EPA-PL significantly increased CPT, peroxisomal β-oxidation enzymes activities and CPT-1a mRNA level. Alterations of hepatic lipogenic gene expressions, such as FAS, G6PDH, ACC, SCD-1 and SREBP-1c were consistent with changes in related enzyme activities.ConclusionsAccording to our study, EPA-PL supplementation was efficacious in suppressing body fat accumulation, and alleviating insulin resistance and hepatic steatosis by modulating the secretion of adipocytokines and inflammatory cytokines, suppression of SREBP-1c mediated lipogenesis and enhancement of fatty acid β-oxidation. These results demonstrate that EPA-PL is a novel beneficial food component for the prevention and improvement of metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice

et al. 2013

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“…Furthermore, n‐3 PC intake may also lead to a decrease in hepatic cholesterol level. The activity of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase was shown to be suppressed as a result of fish oil intake , and enhanced secretion of bile cholesterol was observed in rabbits being on a n‐3 PC‐rich diet . Other authors demonstrated that dietary n‐3 PUFAs may inhibit the activity of delta‐5 and delta‐9 desaturases .…”

Section: Impact Of Diet On Lipid Disordersmentioning

confidence: 99%

Alterations of specific lipid groups in serum of obese humans: a review

Mika

Śledziński

2016

Obesity Reviews

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Obesity is a major contributor to the dysfunction of liver, cardiac, pulmonary, endocrine and reproductive system, as well as a component of metabolic syndrome. Although development of obesity-related disorders is associated with lipid abnormalities, most previous studies dealing with the problem in question were limited to routinely determined parameters, such as serum concentrations of triacylglycerols, total cholesterol, low-density and high-density lipoprotein cholesterol. Many authors postulated to extend the scope of analysed lipid compounds and to study obesity-related alterations in other, previously non-examined groups of lipids. Comprehensive quantitative, structural and functional analysis of specific lipid groups may result in identification of new obesity-related alterations. The review summarizes available evidence of obesity-related alterations in various groups of lipids and their impact on health status of obese subjects. Further, the role of diet and endogenous lipid synthesis in the development of serum lipid alterations is discussed, along with potential application of various lipid compounds as risk markers for obesity-related comorbidities.

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“…A new clinical trial from France showed that fibric acids reduce coronary atherosclerotic progression in dyslipidemic patients 38 . Studies on hypercholesterolemic rabbits showed that soybean phosphatidylcholine (at the hepatobiliary level) may be useful both in prevention of hyperlipidemia and treatment of related atherosclerosis 39 . Miettinen et al 40 showed that sitostanol, a plant sterol incorporated into margarine, inhibits gastrointestinal absorption of cholesterol.…”

Section: Discussionmentioning

confidence: 99%

“…38 Studies on hypercholesterolemic rabbits showed that soybean phosphatidylcholine (at the hepatobiliary level) may be useful both in prevention of hyperlipidemia and treatment of related atherosclerosis. 39 Miettinen et al 40 showed that sitostanol, a plant sterol incorporated into margarine, inhibits gastrointestinal absorption of cholesterol. Moghadasian et al 41 showed that treating ApoEdeficient mice with Tall oil-derived phytosterols reduced their atherosclerotic lesions.…”

Section: Discussionmentioning

confidence: 99%

Slowed Progression or Elimination of Atherosclerosis by Low-Frequency Electrical Impulses

Chekanov

Mortada

Maternowski

et al. 2003

Journal of Cardiac Surgery

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Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits

Cited by 45 publications

References 32 publications

Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice

Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice

Alterations of specific lipid groups in serum of obese humans: a review

Slowed Progression or Elimination of Atherosclerosis by Low-Frequency Electrical Impulses

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