Dietary plant flavonoids in prevention of obesity and diabetes

Dinda, Biswanath; Dinda, Manikarna; Roy, Arup; Dinda, Subhajit

doi:10.1016/bs.apcsb.2019.08.006

Cited by 81 publications

(52 citation statements)

References 178 publications

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“…Thus, at present, it is considered that the most efficient approach to prevent or delay T2D and obesity is the reduction of sedentarism and changes in dietary habits. In this regard, flavonoids, which are natural dietary compounds abundant in vegetables and fruits, have attracted a great interest because of their lack of toxicity and potential ability to act as highly effective chemopreventive agents against T2D and obesity [5,6]. The aim of the present review is summarizing the molecular basis of the chemopreventive activity of flavonoids related to insulin signaling during T2D and obesity.…”

Section: Introductionmentioning

confidence: 99%

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Ramos

2021

Cells

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Type 2 diabetes (T2D) and obesity are relevant worldwide chronic diseases. A common complication in both pathologies is the dysregulation of the insulin-signaling pathway that is crucial to maintain an accurate glucose homeostasis. Flavonoids are naturally occurring phenolic compounds abundant in fruits, vegetables and seeds. Rising evidence supports a role for the flavonoids against T2D and obesity, and at present, these compounds are considered as important potential chemopreventive agents. This review summarizes in vitro and in vivo studies providing data related to the effects of flavonoids and flavonoid-rich foods on the modulation of the insulin route during T2D and obesity. Notably, few human studies have evaluated the regulatory effect of these phenolic compounds at molecular level on the insulin pathway. In this context, it is also important to note that the mechanism of action for the flavonoids is not fully characterized and that a proper dosage to obtain a beneficial effect on health has not been defined yet. Further investigations will contribute to solve all these critical challenges and will enable the use of flavonoids to prevent, delay or support the treatment of T2D and obesity.

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Section: Introductionmentioning

confidence: 99%

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Ramos

2021

Cells

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“…In a high-fat-induced obesity model in C57BL/6 mice, the activation of AMPK significantly reduced liver fat accumulation and prevented diabetes by inhibiting gluconeogenesis. Insulin-sensitive PI3K/AKT signaling affects glucose and lipid homeostasis in the body [20]. The PI3K/AKT pathway is also involved in the defocused low-energy shock wave in activated adipose tissue-derived stem cells [21].…”

Section: Discussionmentioning

confidence: 99%

Liraglutide may affect visceral fat accumulation in diabetic rats via changes in FTO, AMPK, and AKT expression

Xiao

Yang

Liu

et al. 2021

Int J Diabetes Dev Ctries

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Purpose The aim of this study is to explore the effects of liraglutide (LRG) on the expression of FTO, AMPK, and AKT in the visceral adipose tissues of obese and diabetic rats and the underlying mechanisms thereof. Methods Thirty SPF-grade, male SD rats were randomly divided into the healthy control, diabetic model (DM), and DM + LRG groups. The DM and DM + LRG groups were administered normal saline and LRG (0.6 mg/kg/d), respectively. After 12 weeks, the body weight of the rats was measured, and their visceral adipose tissues were collected and weighed; the levels of serum biochemical indicators and FTO, AMPK, and AKT in these tissues were then measured using qRT-PCR and western blotting. Results Compared to the control group, the body weight and visceral fat accumulation and blood glucose, TG, TC, and LDL-C levels increased significantly, while the HDL-C levels decreased significantly, in the DM group (p < 0.05). After LRG treatment, the HDL-C levels increased significantly, but the levels of the other indicators decreased significantly (p < 0.05). Compared to the control group, the visceral adipose tissue levels of FTO and AKT increased significantly, while the AMPK levels decreased significantly in the DM group (p < 0.05). After LRG treatment, the FTO and AKT levels decreased significantly, and the AMPK levels increased significantly (p < 0.05). Conclusion LRG may activate and inhibit the AMPK and AKT pathways, respectively, and decrease FTO expression, thereby alleviating abdominal obesity in type 2 diabetes.

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“…A HFD could directly induce a significant decrease in m-Glut4 protein expression, while Pt-PS supplementation significantly elevated the expression of key proteins in the plasma membrane of skeletal muscle cells. Glut4 translocation is predominantly triggered by PI3K/Akt signaling [36], in which several proteins are involved, including phosphorylated IRS1, PI3K-IRS1 and phosphorylated Akt. Hatem-Vaquero et al reported that obvious peripheral insulin resistance resulted from the inactivation of the PI3K/Akt pathway and the reduction of Glut4 expression in ILK-depleted mice [37].…”

Section: Discussionmentioning

confidence: 99%

Phosphatidylserine from Portunus trituberculatus Eggs Alleviates Insulin Resistance and Alters the Gut Microbiota in High-Fat-Diet-Fed Mice

et al. 2020

Marine Drugs

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Portunus trituberculatus eggs contain phospholipids, whose components and bioactivity are unclear. Here, we investigated the fatty acid composition of phosphatidylserine from P. trituberculatus eggs (Pt-PS). Moreover, its effects on insulin resistance and gut microbiota were also evaluated in high-fat-diet-fed mice. Our results showed that Pt-PS accounted for 26.51% of phospholipids and contained abundant polyunsaturated fatty acids (more than 50% of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)). Animal experiments indicated that Pt-PS significantly decreased body weight and adipose weight gain, improved hyperglycemia and hyperinsulinemia, mitigated insulin resistance, and regulated circulatory cytokines. Pt-PS activated insulin receptor substrate 1 (IRS1) and increased the levels of IRS1-associated phosphatidylinositol 3-hydroxy kinase (PI3K), phosphorylated protein kinase B (Akt) protein, and plasma membrane glucose transporter 4 protein. Furthermore, Pt-PS modified the gut microbiota, inducing, especially, a dramatic decrease in the ratio of Firmicutes to Bacteroidetes at the phylum level, as well as a remarkable improvement in their subordinate categories. Pt-PS also reduced fecal lipopolysaccharide concentration and enhanced fecal acetate, propionate, and butyrate concentrations. Additionally, the effects of Pt-PS on alleviation of insulin resistance and regulation of intestinal bacteria were better than those of phosphatidylserine from soybean. These results suggest that Pt-PS mitigates insulin resistance by altering the gut microbiota. Therefore, Pt-PS may be developed as an effective food supplement for the inhibition of insulin resistance and the regulation of human gut health.

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Dietary plant flavonoids in prevention of obesity and diabetes

Cited by 81 publications

References 178 publications

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Liraglutide may affect visceral fat accumulation in diabetic rats via changes in FTO, AMPK, and AKT expression

Phosphatidylserine from Portunus trituberculatus Eggs Alleviates Insulin Resistance and Alters the Gut Microbiota in High-Fat-Diet-Fed Mice

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