Dietary phytochemicals/nutrients as promising protector of breast cancer development: a comprehensive analysis

Samanta, Suman Kumar; Choudhury, Paramita; Sarma, Partha Pratim; Gogoi, Bhaskarjyoti; Gogoi, Neelutpal; Devi, Rajlakshmi

doi:10.1007/s43440-022-00373-0

Cited by 7 publications

(6 citation statements)

References 116 publications

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“…Além disso, a individualidade genética tem sido cada vez mais considerada na elaboração de estratégias dietéticas personalizadas para a prevenção do câncer de mama (Samanta et al, 2022). Estudos, como o de Alathari et al (2020) e Ruiz-Ballesteros et al (2020, destacam a importância de identificar polimorfismos genéticos relacionados ao metabolismo de nutrientes específicos, como folato e vitamina D, e adaptar a dieta de acordo com esses perfis genéticos para maximizar os efeitos protetores contra o câncer mamário.…”

Section: Resultados E Discussõesunclassified

Nutrigenômica na prevenção e tratamento do câncer de mama: explorando as interseções entre dieta, genes e epigenética

Lopes,

Castro,

Sampaio

et al. 2024

Cad. Pedagógico

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Introdução: A nutrigenômica investiga a interação entre dieta e genes, sendo relevante no contexto do câncer de mama, uma das principais causas de mortalidade feminina global. A compreensão dos mecanismos moleculares é crucial para estratégias de prevenção e tratamento. Metodologia: Uma revisão sistemática foi realizada, abrangendo estudos publicados entre 2020 e 2024. Foram pesquisadas bases como PubMed, Scopus e Web of Science, selecionando artigos que exploravam a relação entre dieta, expressão gênica e o câncer de mama. Resultados e Discussões: Assim como os genes BRCA1 e TP53, estudos demonstraram a influência da dieta com o processo carcinogênico para mama. Compostos alimentares como ômega-3 e resveratrol ofereceram potencial protetor. A modulação epigenética pela dieta e microbiotas específicas também impactaram no risco de doença. Além disso, novos estudos destacaram a importância da análise de marcadores genéticos para a predição de resposta a tratamentos específicos e a personalização de abordagens terapêuticas. Conclusão: A nutrigenômica proporciona perspectivas promissoras para a pesquisa dos nutrientes e a capacidade de modular a expressão gênica, influenciando a prevenção, o tratamento e a resposta terapêutica do câncer de mama. Estratégias dietéticas personalizadas, ancoradas em genes como BRCA1 e TP53, emergem como essenciais para uma abordagem mais precisa. Os avanços nesse campo promovem estratégias mais eficazes na oncologia nutricional, embora ressaltemos a necessidade contínua de pesquisas para consolidar e expandir esse conhecimento. Aprofundar o entendimento das interações moleculares abre portas para intervenções terapêuticas mais direcionadas, ampliando o arsenal contra o câncer de mama e favorecendo uma abordagem mais integrada da saúde feminina. A interdisciplinaridade entre a nutrigenômica e a oncologia clínica torna-se fundamental para traduzir os achados em benefícios tangíveis para pacientes, reforçando a importância da colaboração entre diferentes áreas de conhecimento na luta contra o câncer de mama.

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Section: Resultados E Discussõesunclassified

Nutrigenômica na prevenção e tratamento do câncer de mama: explorando as interseções entre dieta, genes e epigenética

Lopes,

Castro,

Sampaio

et al. 2024

Cad. Pedagógico

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“…Food-derived items are especially intriguing for research termed as "chemopreventive agents" owing to their safety and lack of stigma as "medicine," and they may find broad, long-term usage in persons at normal risk. Phytochemicals may directly or indirectly affect certain molecular targets to exert their positive effects on health [55] . DFs have been used to make cancer chemotherapy drugs ethnobotanically.…”

Section: Chemoprevention Perspectives Of Dietary Foodsmentioning

confidence: 99%

Understanding the prophylactic, chemo preventive, and pharmacotherapeutic perspectives of various dietary foods in breast cancer

Kahale¹

2023

JMPAS

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Currently, one of the most challenging diseases to tis breast cancer. Hormone therapy, surgery, chemotherapy, and radiation have all been used to treat breast cancer for a long time, but they are become eating less and less successful due to serious side effects and rising drug resistance. Numerous dietary foods have been linked to altered cancer genesis and progression pathways, decreased aggressiveness, and growth inhibition of malignant cells. These dietary foods may be advantageous compared to produce medications since they exhibit lower toxicity and negative effects in various investigations. The promises made by dietary foods for breast cancer treatment by focusing on several pathophysiological cascades involved in the onset and progression of breast cancer and their capacity to simultaneously stop metastatic and growth progression. Some of the extensively researched numerous dietary foods that specifically target certain breast cancer pathways and express any of the three attributes are mentioned in article.

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“…The dietary patterns considered different food ingestion, and the results suggested a protective effect of a vegetarian-like diet showing a protection for overall cancer incidence, and interestingly, the lacto-ovo-vegetarian regiment appears to be a gastro-intestinal prevention factor [ 14 ]. Various small phytochemicals, especially dietary phytochemicals such as sulforaphane, mahanine, resveratrol, linolenic acid, diallyl sulfide, benzyl/phenethyl isothiocyanate, etc., have been considered in line with the recent advancement in the acceptance of these types of potential dietary phytochemicals as chemo-preventive agents against the development of breast cancer [ 15 ]. These relations between vegetarian-like diets could explain the major ingestion of vegetal antioxidants molecules; Razis et al described the role of cruciferous vegetables as cancer protection factors specifically the glycosylates—they described the relation between these molecules and the reduction of different cancer types like colorectum, lung, prostate, and breast [ 16 ].…”

Section: Effects Of Glucosinolates Derived From Cruciferous Vegetablesmentioning

confidence: 99%

Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer

et al. 2022

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Because cancer is a multifactorial disease, it is difficult to identify the specific agents responsible for the disease’s progression and development, but lifestyle and diet have been shown to play a significant role. Diverse natural compounds are demonstrating efficacy in the development of novel cancer therapies, including sulforaphane (1-isothiocyanate-4-(methylsulfinyl)butane), a compound found in broccoli and other cruciferous vegetables that promotes key biological processes such as apoptosis, cell cycle arrest, autophagy, and suppression of key signalling pathways such as the PI3K/AKT/mTOR pathway in breast cancer cells. However, one of the primary challenges with sulforaphane treatment is its low solubility in water and oral bioavailability. As a consequence, several investigations were conducted using this component complexed in nanoparticles, which resulted in superior outcomes when combined with chemotherapy drugs. In this study, we discuss the properties and benefits of sulforaphane in cancer therapy, as well as its ability to form complexes with nanomolecules and chemotherapeutic agents that synergize the antitumour response in breast cancer cells.

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Dietary phytochemicals/nutrients as promising protector of breast cancer development: a comprehensive analysis

Cited by 7 publications

References 116 publications

Nutrigenômica na prevenção e tratamento do câncer de mama: explorando as interseções entre dieta, genes e epigenética

Nutrigenômica na prevenção e tratamento do câncer de mama: explorando as interseções entre dieta, genes e epigenética

Understanding the prophylactic, chemo preventive, and pharmacotherapeutic perspectives of various dietary foods in breast cancer

Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer

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