Dietary phytochemicals as the potential protectors against carcinogenesis and their role in cancer chemoprevention

Líšková, Alena; Štefanička, Patrik; Samec, Marek; Šmejkal, Karel; Žúbor, Pavol; Bielik, Tibor; Biskupska-Bodova, Kristina; Kwon, Taeg Kyu; Danko, Ján; Büsselberg, Dietrich; Adamek, Mariusz; Rodrigo, Luís; Kružliak, Peter; Shleikin, A.; Kubatka, Peter

doi:10.1007/s10238-020-00611-w

Cited by 31 publications

(19 citation statements)

References 132 publications

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“…Recent studies have identified that both genetic and environmental factors play a critical role in cancer development and progression. It has also been realized that cancers could be prevented or at least cancer initiation and/or progression could be delayed by naturally-occurring, dietary compounds [ 1 - 4 ]. Most, if not all, of the dietary compounds are derived from plants and often denoted as phytochemicals.…”

Section: Introductionmentioning

confidence: 99%

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

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Section: Introductionmentioning

confidence: 99%

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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“…It was reported that chemical carcinogenesis was inhibited by the blocking agents that could exert their preventive effect by several mechanisms, which included enhancing the detoxification of carcinogens, inhibiting cytochrome P450-mediated activation of carcinogens, scavenging free radicals, and preventing their interaction with DNA 24,25 .…”

Section: Discussionmentioning

confidence: 99%

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2020

IJPSR

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Chemoprevention is the novel approach that inhibits and delays or reverses the process of cancer development by using natural herbs and plant products. The aim of the present study was to evaluate the anticancer efficacy of orally administered Capparis decidua fruit extract (CDE) on skin carcinogenesis model in swiss albino mice by the single topical application of the 7,12 dimethylbenz (a)anthracene (100µg/100µl of acetone) followed by croton oil after 2 weeks (1% in acetone/thrice in a week). Oral administration of the CDE at a dose of 50 mg/kg b.wt./day during the peri initiation stage (one week before DMBA and one week after the application followed by croton oil till the end of the experiment) and post-initiation stage (after 2 weeks DMBA application, from the day of croton oil treatment till the end of the experiment). A significant reduction in the tumor incidence, tumor burden, and a cumulative number of papillomas was observed, along with the increase in the average latent period in mice treated with CDE drugs compared with DMBA/croton oil-treated group III. A significant elevation was seen in the level of the non-enzymatic antioxidant reduced glutathione (GSH), antioxidant enzymes catalase and superoxide dismutase with a reduction in lipid peroxidation (LPO) in the liver and skin of the mice in both the above-mentioned groups in comparison to DMBA+ croton oil-treated group. The results clearly indicate that the CDE has potent chemopreventive efficacy against two-stage skin carcinogenesis, which can be attributed to its antioxidative and antiperoxidative effects. INTRODUCTION: Cancer is one of the most important causes of death in the population after cardiovascular diseases. It is the second leading cause of death in developed countries. Cancer is not a single disease but is a group of many different diseases that all share biological and pathological characteristics.

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“…Aryl hydrocarbon receptor (AhR) is defined as ligand-activated transcription factor, which binds to exogenous ligands leading to nuclear translocation of AhR and consequent dimerisation with associated AhR protein. A subsequent interaction between the heterodimer with consensus DNA sequence xenobiotic responsive element and the enhancer regions of target genes increases their transcription [37,66]. Inactivation of carcinogens, such as B[a]P by phytochemicals, can lead to the protection against DNA damage as was demonstrated in several studies concerning cancer chemoprevention and therapy [67][68][69].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Carcinogens cause damage of DNA including single-strand breaks (SSBs) or double-strand breaks (DSBs), oxidative-induced lesions, covalently bound DNA chemical adducts, and DNA-DNA or DNA-protein cross-links [36]. Carcinogens are represented by heterocyclic aromatic amines (tobacco smoke, diesel exhaust, incineration ash), polycyclic aromatic hydrocarbons (roasting, grilling, baking, smoking), ultraviolet (UV) and infrared (IR) radiation, aristocholic acid, nitrosamines (drugs, cosmetics, rubber industry), mycotoxins, asbestos, and some nanoparticles [36,37]. Specific examples of carcinogens and their DNA damaging mechanisms are summarised in Table 1.…”

Section: Exposure To Carcinogensmentioning

confidence: 99%

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

et al. 2020

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Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.

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Dietary phytochemicals as the potential protectors against carcinogenesis and their role in cancer chemoprevention

Cited by 31 publications

References 132 publications

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

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Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

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