Dietary phospholipids, hepatic lipid metabolism and cardiovascular disease

Abstract

The concept of using naturally occurring compounds such as phospholipid to treat or prevent hepatic steatosis is very attractive. Controlled human trials are, however, required to verify the efficacy of this approach. It is also important that additional research be conducted to determine the extent to which certain phospholipids have the ability to increase plasma HDL levels and potentially affect the onset or development of cardiovascular disease.

Comparative Study of EPA-enriched Phosphatidylcholine and EPA-enriched Phosphatidylserine on Lipid Metabolism in Mice

“…And further comparative study is critical to evaluate the bioactivity of EPA-PC and EPA-PS. Consistent results have been obtained supporting the concept that phospholipid from various sources i.e., soybean, safflower, egg and fish roe can reduce liver lipid levels 28 . The reductions of the activities of hepatic enzymes in fatty acid synthesis in rats fed soybean phospholipid were confirmed in the previous study 29,30 .…”

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

“…In fact, their cardiovascular blood marker levels, such as homocysteine, improved significantly during the trial (p < 0.001) [14]. Reviews of clinical studies on the use of MLR in the long-term treatment of cardiovascular and other diseases concluded that there was no evidence of any toxicity from glycerolphospholipids [3] [15].…”

Characterization of Phospholipid Molecular Species by Means of HPLC-Tandem Mass Spectrometry

“…The characterization of the phospholipid profile is a strategic tool in order to evaluate the nutritional properties of several food products, food ingredients, nutraceuticals, functional foods, cosmetics and pharmaceutical products containing polar lipids (Cohn et al, 2008) or liposomes (Henna Lu et al, 2010). Moreover, the increased commercial use of phospholipids as ingredients for functional food, baby-food and pet food, has lead to the development of specific analytical methods in order to separate and identify phospholipids (Le Grandois et al, 2009;Standal et al, 2010;Winther et al, 2010).…”

“…The positive effects of dietary phospholipids (PL) on hepatic lipid metabolism, atherosclerosis, obesity-related disorders and cardiovascular disease is a consistent experimental evidence (Shirouchi et al, 2007). The daily intake of PL can vary from 2 to 8 g per day and represents 1-10% of total daily fat intake (Cohn et al, 2008). The main natural phospholipid is phosphatidylcholine (lecithin) which is completely absorbed in humans.…”