Dietary Phenolic Acids of<i>Macrotyloma uniflorum</i>(Horse Gram) Protect the Rat Heart Against Isoproterenol-Induced Myocardial Infarction

Panda, Vandana; Laddha, Ankit P.; Nandave, Mukesh; Srinath, Sudhamani

doi:10.1002/ptr.5620

Cited by 25 publications

(14 citation statements)

References 25 publications

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“…In our previous study, we found that angoroside C can be metabolized to ferulic acid in rats, which is one of the functional phenolic acids that commonly exist in a variety of plants, and multiple biological and pharmacological properties such as anti-oxidant ( Perezternero et al, 2017 ), anti-inflammatory ( Salazar-López et al, 2017 ), anti-obesity ( Salazar-López et al, 2017 ), and anti-depression ( Liu et al, 2017b ) have been reported for this compound. Most important of all, ferulic acid has been demonstrated to have protective effects against myocardial ischaemia ( Liu et al, 2016 ; Panda et al, 2016 ), which is usually considered to induce ventricular remodeling. Therefore, it is important and meaningful to pay more attention to the pharmacokinetic characteristics of ferulic acid in vivo after the oral administration of angoroside C during pharmacodynamic evaluations.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS

Zhang

et al. 2018

Front. Pharmacol.

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Angoroside C is a phenylpropanoid glycoside compound isolated from the dried root of Scrophularia ningpoensis Hemsl., which possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc. However, few investigations have been conducted on the absorption, distribution, metabolism, and excretion (ADME) study of angoroside C. Thus, a fast ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UPLC-MS/MS) method was established for the determination of angoroside C and its metabolite ferulic acid in rat plasma and tissue homogenate. The two analytes were extracted from the biosamples using a simple protein precipitation with acetonitrile. The developed method was validated and successfully applied to the pharmacokinetics, bioavailability and tissue distribution study after the intragastric administration of angoroside C (100 mg/kg) or the intravenous administration of angoroside C (5 mg/kg), respectively. The results showed that angoroside C can be absorbed extremely quickly (Tmax = 15 min), can be eliminated very rapidly (t1/2 = 1.26 h), and its oral bioavailability is only about 2.1%. Furthermore, angoroside C was extensively distributed in all main organs (liver, heart, spleen, lung, kidney, and brain), and the highest concentration was detected in the lung 15 min after oral administration. This paper also indicated that angoroside C could be converted to the active metabolite ferulic acid in vivo. The maximum concentrations of ferulic acid in the kidney occurred at 6 h after oral administration. In summary, this study explored some of the pharmacokinetic characteristics of angoroside C in vivo, and the data produced could provide a basis for the further investigation of angoroside C.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS

Zhang

et al. 2018

Front. Pharmacol.

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“…17 The extracts of M. uniflorum also exhibited significant analgesic, anti-inflammatory, diuretic hepatoprotective and cardioprotective activities. [18][19][20] These activities may be mediated through the antioxidant properties of seeds of M. uniflorum.…”

Section: Discussionmentioning

confidence: 99%

In vitro Antioxidant Activity of Methanolic and Ethanolic Extracts of seeds of Macrotyloma uniflorum

Parasuraman

Vanishya

Raipan³

2021

FRA

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Objectives: To study the antioxidant activity of methanolic and ethanolic extracts of seeds of Macrotyloma uniflorum. Methods: The seeds of M. uniflorum were extracted with methanol and ethanol and used for the phytochemical analysis and determination of antioxidant activity. The in vitro antioxidant activity was studied using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging methods. Result: Ethanolic extracts of M. uniflorum showed more phenolic content (63.48 mg GAE/g) than methanolic extract of M. uniflorum (45.84 mg GAE/g). In total flavonoid content analysis, methanolic and ethanolic extracts of M. uniflorum showed the presence of flavonoid content of 15.31 mg Rutin/g and 15.44 mg Rutin/g, respectively. In DPPH assay, methanolic and ethanolic extracts of M. uniflorum exhibited 50% free radical scavenging activity at 797.71 ± 34.38 μg/mL and 938.80 ± 66.05 μg/mL (mean ± standard deviation; n = 3), respectively. In hydroxyl radical scavenging assay, methanolic and ethanolic extracts of M. uniflorum exhibited 50% fee radical scavenging activity at 770.27 ± 11.64 μg/ mL and 844.94 ± 35.12 μg/mL (mean ± standard deviation; n = 3), respectively. Ascorbic acid exhibited potent free radical scavenging with IC 50 value of 60.54 ± 5.23 μg/mL in DPPH method and 207.98 ± 14.26 μg/mL (mean ± standard deviation; n = 3) in hydroxyl radical scavenging method. Conclusion: Ethanolic extracts of M. uniflorum showed more phenolic content than methanolic extract of M. uniflorum. In both, DPPH and hydroxyl radical scavenging assay, methanolic and ethanolic extracts of M. uniflorum exhibited antioxidant activity at higher concentration.

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“…Both coumaric acid and ferulic acid have been reported to attenuate pathological cardiac remodeling. In addition, studies suggest that ferulic acid inhibits HDAC activity [ 74 , 120 , 121 , 122 , 123 ]. Combined, these studies would suggest that hydroxycinnamic acids protect the heart, in part, through direct changes in gene expression.…”

Section: Phytochemicalsmentioning

confidence: 99%

Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure

Evans

Ferguson

2018

Nutrients

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Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent cardiac pump dysfunction. However, these drugs fail to target other redundant intracellular signaling pathways and, therefore, limit drug efficacy. As such, it has been postulated that compounds designed to target shared downstream mediators of these signaling pathways would be more efficacious for the treatment of HF. Histone deacetylation has been linked as a key pathogenetic element for the development of HF. Lysine residues undergo diverse and reversible post-translational modifications that include acetylation and have historically been studied as epigenetic modifiers of histone tails within chromatin that provide an important mechanism for regulating gene expression. Of recent, bioactive compounds within our diet have been linked to the regulation of gene expression, in part, through regulation of the epi-genome. It has been reported that food bioactives regulate histone acetylation via direct regulation of writer (histone acetyl transferases, HATs) and eraser (histone deacetylases, HDACs) proteins. Therefore, bioactive food compounds offer unique therapeutic strategies as epigenetic modifiers of heart failure. This review will highlight food bio-actives as modifiers of histone deacetylase activity in the heart.

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Dietary Phenolic Acids ofMacrotyloma uniflorum(Horse Gram) Protect the Rat Heart Against Isoproterenol-Induced Myocardial Infarction

Cited by 25 publications

References 25 publications

Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS

Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS

In vitro Antioxidant Activity of Methanolic and Ethanolic Extracts of seeds of Macrotyloma uniflorum

Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure

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