Dietary Patterns Related to Triglyceride and High-Density Lipoprotein Cholesterol and the Incidence of Type 2 Diabetes in Korean Men and Women

Song, Sihan

doi:10.3390/nu11010008

Cited by 31 publications

(25 citation statements)

References 50 publications

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“…As validated by a Chinese population-based study, environmental tobacco exposure increased T2DM risks with a dose-response relationship (36), which also verified our results laterally. Higher HDL-c and lower TG levels were associated with lower risks of T2DM prevalence in both genders in our research (Table 2), which were consistent with other studies (37,38). A nationwide population-based study in Korea enrolling 5,114,735 adults with a median follow-up period of 5.1 years had found that lower means of HDL-C were associated with higher risks of diabetes incidence in a stepwise manner (39).…”

Section: Discussionsupporting

confidence: 91%

Gender differences of relationship between serum lipid indices and type 2 diabetes mellitus: a cross-sectional survey in Chinese elderly adults

Guo¹,

Li²,

Fang³

et al. 2021

Ann Transl Med

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Background: To investigate the gender differences of the relationships between clinical serum lipid indices and type 2 diabetes mellitus (T2DM) in Chinese elderly adults.Methods: Between 2014 and 2016, participants selected from three communities in an urban district of Shanghai were measured for serum lipid indices of low-density lipoprotein cholesterol (LDL-c), highdensity lipoprotein cholesterol (HDL-c), total cholesterol (TC), and triglyceride (TG). Age and multivariate adjusted logistic regression models were utilized to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of serum lipid indices on T2DM prevalence.Results: In total, 4,023 male and 3,862 female participants were included in this study, with the T2DM prevalence proportions of 13.03% and 11.73%, respectively. In association analysis, the serum levels of LDL-c, HDL-c, TC were significant between non-T2DM individuals and T2DM patients in men, but the HDL-c and TG in women. LDL-c/HDL-c, TG/HDL-c, and TC/HDL-c ratios were associated with the T2DM prevalence only in women. In the multivariate analysis, a higher serum LDL-c level was positively associated with a reduced risk of T2DM prevalence in men with OR (95% CI) of 0.57 (0.39-0.85) (P=0.006).Higher ratios of LDL-c/HDL-c, TG/HDL-c, and TC/HDL-c were all more likely associated with the decreased risks of T2DM prevalence with the ORs ranging from 0.45 to 0.62 in men (all P<0.05), but not in women.Conclusions: High LDL-c concentration was significantly associated with a lower T2DM prevalence in men. A gender difference of the associations between the lipid ratios and T2DM prevalence was observed for LDL-c/HDL-c and TC/HDL-c ratios, which might be validated in female T2DM prevalence in the future.

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Section: Discussionsupporting

confidence: 91%

Gender differences of relationship between serum lipid indices and type 2 diabetes mellitus: a cross-sectional survey in Chinese elderly adults

Guo¹,

Li²,

Fang³

et al. 2021

Ann Transl Med

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“…T2DM is a metabolic disease characterized by hyperglycemia and caused by relatively insufficient insulin secretion or insulin resistance (2). However, the pathogenesis of T2DM is complicated, including heredity, lifestyle, environmental, as well as unknown factors (3). Some studies have indicated that intestinal flora disorders can mediate the occurrence of T2DM, particularly those inducing insulin resistance by regulating visceral adipose tissue (VAT) inflammation.…”

Section: Introductionmentioning

confidence: 99%

Mechanism research on the interaction regulation of Escherichia and IFN-γ for the occurrence of T2DM

Lv¹,

Li²,

Li³

et al. 2021

Ann Palliat Med

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Background: Type 2 diabetes mellitus (T2DM) is a major social and public health problem which may be induced by intestinal flora imbalance through inflammatory response, and the specific mechanism remains unclear. In this study, we aim to explore the interaction network of intestinal flora and cell inflammation in T2DM.Methods: This a case-control study. Patients with T2DM was the case group and healthy people as control.The differences of cytokine expression levels between patients with T2DM and healthy controls were assessed by using flow cytometry. The diversity and abundance of intestinal flora were evaluated by using 16S rRNA three-generation full-length sequencing technology.Results: A total of 29 patients with T2DM and 28 healthy controls were included for analysis. Compared with the healthy control group, the expression levels of plasma cytokine interleukin-2 (IL-2) (P=0.0000006), IL-6 (P=0.000193), tumor necrosis factor α (TNF-α) (P=0.016), interferon-γ (IFN-γ) (P=0.000036) and interleukin-17 (IL-17) (P=0.004) were significantly up-regulated in T2DM patients, and the abundance of Megamonas_funiformis (P=0.0016) and Escherichia (P=0.049) in the intestine were significantly increased.In contrast, the abundance of Bacteroides_stercoris (P=0.0068), Bacteroides_uniformis (P=0.033), and Phascolarctobacterium_faecium (P=0.033) were decreased in T2DM patients. Further, differentially expressed Escherichia had a positive correlation with by Pearson correlation analysis. Conclusions:The interaction network between the intestinal bacteria Escherichia and the cytokine IFN-γ may drive inflammation in visceral adipose tissue (VAT), indicating insulin signal transduction can be inhibited in adipocytes to induce insulin resistance.

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“…Apart from evaluating the association between micronutrients and the risk of type 2 diabetes, the role of macronutrients and other metabolites in the development of this condition have been studied extensively. Song et al [15] sought to examine whether dietary patterns that explain the variation of the triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio were associated with the incidence of type 2 diabetes in Korean men and women. The authors found evidence that suggests that dietary patterns associated with low levels of TG/HDL-C ratio may have the potential to reduce the risk of type 2 diabetes.…”

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confidence: 99%

Dietary Intake and Type 2 Diabetes

Ojo

2019

Nutrients

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This editorial aims to examine the risk factors associated with type 2 diabetes and to discuss the evidence relating to dietary strategies for managing people with this condition. It is clear from the evidence presented that a range of dietary interventions can provide useful approaches for managing people with type 2 diabetes, including the regulation of blood glucose and lipid parameters, and for reducing the risks of acute and chronic diabetic complications.

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Dietary Patterns Related to Triglyceride and High-Density Lipoprotein Cholesterol and the Incidence of Type 2 Diabetes in Korean Men and Women

Cited by 31 publications

References 50 publications

Gender differences of relationship between serum lipid indices and type 2 diabetes mellitus: a cross-sectional survey in Chinese elderly adults

Gender differences of relationship between serum lipid indices and type 2 diabetes mellitus: a cross-sectional survey in Chinese elderly adults

Mechanism research on the interaction regulation of Escherichia and IFN-γ for the occurrence of T2DM

Dietary Intake and Type 2 Diabetes

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