Dietary Patterns, Metabolomic Profile, and Nutritype Signatures Associated with Type 2 Diabetes in Women with Postgestational Diabetes Mellitus: MyNutritype Study Protocol

Hasbullah, Farah Yasmin; Yusof, Barakatun Nisak Mohd; Ghani, Rohana Abdul; Daud, Zulfitri Azuan Mat; Appannah, Geeta; Abas, Faridah; Shafie, Nurul Husna; Khir, Hannah Izzati Mohamed; Murphy, Helen

doi:10.3390/metabo12090843

Cited by 6 publications

(9 citation statements)

References 38 publications

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“…Secondly, some analyses were not adequately powered due to the small sample size. Results from this small-scale pilot study are promising and further explorations on dietary patterns will be conducted in a more extensive study (Hasbullah et al, 2022). Metabolomic biomarkers related to dietary patterns will also be investigated to better understand the mechanism involved in T2D development in women with a history of GDM, thus helping to inform on the appropriate nutritional interventions for T2D prevention in women with a history of GDM (Hasbullah et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…This comparative cross-sectional study was a pilot study for a more extensive study aiming to investigate the dietary patterns, metabolomic profile, and risk of T2D in Malaysian women with a history of GDM (Hasbullah et al, 2022). The study has been registered on ClinicalTrials.gov (NCT04190199 Participants were Malaysian women aged 18-49 years old who had previously given birth and had no prior diagnosis of type 1 or type 2 diabetes.…”

Section: Study Design and Participantsmentioning

confidence: 99%

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Dietary patterns associated with the risk of type 2 diabetes in women with and without a history of gestational diabetes mellitus: A pilot study

Hasbullah¹,

Yusof²,

Ghani³

et al. 2023

Mal J Nutr

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Introduction: There is limited evidence on dietary patterns and the risk of type 2 diabetes (T2D) in women with a history of gestational diabetes mellitus (GDM) compared to their non-GDM counterparts, especially in the Asian population. The pilot study investigated dietary patterns in women with a history of GDM (HGDM) and without a history of GDM (non-HGDM), and the association with T2D risk. Methods: This comparative cross-sectional study involved 64 women (32 HGDM, 32 non-HGDM). Food intake was assessed using a validated food frequency questionnaire. Principal component analysis derived the dietary patterns. T2D risk score was determined using the Finnish Diabetes Risk Score tool. Results: HGDM group had significantly higher proportion of first-degree family history of diabetes; higher risk of T2D and better diabetes knowledge; lower gestational weight gain and postpartum weight retention; and consumed more fast food than nonHGDM. ‘Rice-noodle-pasta-meat’ dietary pattern was significantly associated with increased T2D risk after adjusting for age (β=0.272, p=0.032). ‘Bread-cereals-fast food-meat’ dietary pattern was positively and significantly associated with T2D risk after adjusting for confounders, including age, education level, family history of diabetes, diabetes knowledge score, gestational weight gain, and postpartum weight retention (β=0.251, p=0.012). Conclusion: Dietary patterns high in bread, cereals and cereal products, fast food and meat, as well as rice, noodle, pasta and meat were associated with an elevated T2D risk. A more extensive study is warranted to establish the association between dietary patterns and risk of T2D, focusing on women with a history of GDM.

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Section: Discussionmentioning

confidence: 99%

Section: Study Design and Participantsmentioning

confidence: 99%

Dietary patterns associated with the risk of type 2 diabetes in women with and without a history of gestational diabetes mellitus: A pilot study

Hasbullah¹,

Yusof²,

Ghani³

et al. 2023

Mal J Nutr

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“…The food portion sizes in the Malaysian Foods Album will be referred to for food portion calculation [ 23 , 24 ]. Overall, the steps for analysis will be based on established protocols [ 25 , 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

Molecular, Metabolic, and Nutritional Changes after Metabolic Surgery in Obese Diabetic Patients (MoMen): A Protocol for a Multicenter Prospective Cohort Study

et al. 2023

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Metabolic surgery is an essential option in the treatment of obese patients with type 2 diabetes (T2D). Despite its known advantages, this surgery still needs to be introduced in Malaysia. In this prospective study, the pathophysiological mechanisms at the molecular level will be studied and the metabolomics pathways of diabetes remission will be explored. The present study aims to evaluate the changes in the anthropometric measurements, body composition, phase angle, diet intake, biochemistry parameters, adipokines, microRNA, and metabolomics, both pre- and post-surgery, among obese diabetic patients in Malaysia. This is a multicenter prospective cohort study that will involve obese patients (n = 102) with a body mass index (BMI) of ≥25 kg/m2 (Asian BMI categories: WHO/IASO/IOTF, 2000) who will undergo metabolic surgery. They will be categorized into three groups: non-diabetes, prediabetes, and diabetes. Their body composition will be measured using a bioimpedance analyzer (BIA). The phase angle (PhA) data will be analyzed. Venous blood will be collected from each patient for glycated hemoglobin (HbA1c), lipids, liver, renal profile, hormones, adipokines, and molecular and metabolomics analyses. The serum microRNA will be measured. A gene expression study of the adipose tissue of different groups will be conducted to compare the groups. The relationship between the 1HNMR-metabolic fingerprint and the patients’ lifestyles and dietary practices will be determined. The factors responsible for the excellent remission of T2D will be explored in this study.

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“…This cross-sectional study involved women post-GDM from the MyNutritype cohort; the methods have been described in detail elsewhere [ 31 ]. GDM was diagnosed according to the Malaysian Clinical Practice Guidelines [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Maternal and Dietary Factors Are Associated with Metabolic Syndrome in Women with a Previous History of Gestational Diabetes Mellitus

Hasbullah

Yusof

Ghani

et al. 2022

IJERPH

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While it is known that women with a previous history of gestational diabetes mellitus (post-GDM) have a higher risk of metabolic syndrome (MetS), evidence of lifestyle practices from low- and middle-income countries (LMICs) is still scarce. This study aimed to determine the factors associated with MetS in women post-GDM. This cross-sectional study involved 157 women post-GDM (mean age 34.8 ± 5.6 years) sampled from Selangor, Malaysia. We collected data on sociodemographic characteristics and obstetric history. Food intake was assessed using a food frequency questionnaire, and dietary patterns were derived from principal component analysis. MetS was diagnosed according to the 2009 Harmonized criteria. The prevalence of MetS in this study was 22.3%. Western dietary pattern consumption was correlated with MetS, body mass index (BMI), waist circumference, and triglyceride levels. Independent factors associated with MetS were lower education level (odds ratio, OR 4.017, p = 0.007), pre-pregnancy BMI (OR 1.192, p = 0.002), and Caesarean delivery (OR 3.798, p = 0.009). The study identified the maternal and dietary factors associated with MetS in women post-GDM in Malaysia. Community-based interventions that include dietary modification are warranted to prevent MetS and its complications, thus helping to reduce the overall disease burden.

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Dietary Patterns, Metabolomic Profile, and Nutritype Signatures Associated with Type 2 Diabetes in Women with Postgestational Diabetes Mellitus: MyNutritype Study Protocol

Cited by 6 publications

References 38 publications

Dietary patterns associated with the risk of type 2 diabetes in women with and without a history of gestational diabetes mellitus: A pilot study

Dietary patterns associated with the risk of type 2 diabetes in women with and without a history of gestational diabetes mellitus: A pilot study

Molecular, Metabolic, and Nutritional Changes after Metabolic Surgery in Obese Diabetic Patients (MoMen): A Protocol for a Multicenter Prospective Cohort Study

Maternal and Dietary Factors Are Associated with Metabolic Syndrome in Women with a Previous History of Gestational Diabetes Mellitus

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