Dietary patterns in association with the expression of pro-metastatic genes in primary breast cancer

Foroutan-Ghaznavi, Mitra; Mazloomi, Seyed Mohammad; Montazeri, Vahid; Pirouzpanah, Saeed

doi:10.1007/s00394-022-02884-1

Cited by 2 publications

(4 citation statements)

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“…In an Iranian study, the relationship linking the prudent DP and the expression of genes RhoA (Ras homolog family member-A) and ROCK (Rho-associated kinase) which are pro-metastatic in BC was examined. Expressions of genes RhoA and ROCK were reduced extensively by 74% (95%CI: 0.09–0.95) and 71% (95%CI: 0.08–0.84), respectively, by strictly following Prudent Diet [ 45 ]. This significant reduction is observed even in global studies, including several meta-analyses which also show that prudent diet lowers BC risk by 11% [ 46 , 47 , 48 ].…”

Section: Dietary Patternsmentioning

confidence: 99%

“…Additionally, a prudent DP, which is rich in seafood, is high in omega 3 polyunsaturated fatty acids. These PUFA’s are known to transport the RhoA back into the cytoplasm from the cell membrane surface, thereby downregulating the activity of RhoA and ROCK [ 45 ]. Fiber and antioxidants such as polyphenols glycosylate, and indoles found in fruits, vegetables, and whole grains can lessen BC risk by inhibiting inflammation and reducing oxidative through the inducing of detoxifying enzymes, and fiber binding with estrogens, leading to improved elimination thereby reducing the concentration of estrogen in the plasma [ 49 , 50 , 51 ].…”

Section: Dietary Patternsmentioning

confidence: 99%

“…Western DP is illustrated by elevated intake of soft drinks, hydrogenated fat, animal fat, sugar, fast food, refined cereals, sweets, meat, and processed meat as reported in two Iranian studies [ 45 , 52 ]. Foroutan-Ghaznavi et al found that the overexpression of the gene RhoA in patients who followed a western DP was significant (OR: 3.15) and this may increase cell proliferation ( Figure 1 ) [ 45 ]. Another study assessed the correlation linking Western DP and two subtypes of BC, namely ILC (invasive lobular carcinoma and IDC (invasive ductal carcinoma).…”

Section: Dietary Patternsmentioning

confidence: 99%

“…Also, the body’s growth factor, IGF-1, might activate a specific pathway ( RhoA / ROCK ) through a series of signals (PI3K/Akt/mTOR). This activation could aid in the increased growth of breast tumors [ 45 ].…”

Section: Dietary Patternsmentioning

confidence: 99%

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Dietary Patterns Associated with Breast Cancer in the Middle East: A Scoping Review

Zamzam,

Said,

Yaghi

et al. 2024

Nutrients

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Breast cancer (BC) is the most predominant malignancy in Arab women in the Middle East, and yearly increases in occurrence by 37.5 and mortality rates by 15.2 for every 100,000 in 2019. This review explores the gap in research investigating the role of dietary patterns and BC in Middle Eastern countries. Furthermore, we analyze the evidence connecting these patterns to BC prevalence in the region, discussing implications for public health and preventive strategies. PubMed, ProQuest, and Cochrane databases were searched up to November 2023. Articles published in English from 2000 to 2023 were identified. Our search included dietary patterns (DP), their association with BC and specific to Middle Eastern Regions. The majority of existing research is concentrated in Iran, with limited illustration from Saudi Arabia, Turkey, and Jordan, and a notable absence of studies from other Middle Eastern countries. We found that dietary intervention is closely related to the occurrence, development, and prognosis of BC. Most DPs such as the Dietary Approaches to Stop Hypertension, Mediterranean, Plant-based and Paleolithic diets are identified to decrease the probability of BC by being rich sources of fiber, healthy fats, and vitamins and minerals. However, there are few DPs that increase the risk of BC, because of the existence of foods such as unhealthy fats, low fiber, sugars, and fried foods in those patterns which contribute to increasing the risk factors associated with BC. This review highlights the intricate connection between DPs and the risk of BC in the Middle East, revealing potential protective effects and heightened risks linked to specific dietary elements.

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