Dietary patterns, cardiovascular risk factors and C-reactive protein in a healthy Italian population

Centritto, Floriana; Iacoviello, Licia; Giuseppe, Romina di; Curtis, Amalia De; Costanzo, Simona; Zito, Francesco; Grioni, Sara; Sieri, Sabina; Donati, Maria Benedetta; Gaetano, Giovanni de; Castelnuovo, Augusto Di

doi:10.1016/j.numecd.2008.11.009

Cited by 142 publications

(144 citation statements)

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“…17 Socio-economic status was defined by a score based on eight variables [(income, education, employment, housing, ratio between the number of live-in partners and the number of rooms (both current and in childhood) and availability of hot water at home during childhood)]; the higher the score, the higher the socio-economic level. 15 Physical activity was assessed by a structured questionnaire and expressed as daily energy expenditure in metabolic equivalent task-hours (MET-h). 18 Metabolic syndrome was defined using the ATP III criteria.…”

Section: Definition Of Risk Factorsmentioning

confidence: 99%

“…We took advantage of a large adult population-based survey we performed in the Molise region, Italy 14,15 to study the association of each of the four major platelet indicesnamely, platelet count, plateletcrit, mean platelet volume, and platelet distribution width -with the other three indices and with a number of biochemical, environmental and clinical variables. Moreover, since Biino et al 13 found large differences in platelet count levels across Sardinia villages, we also studied the levels of platelet indices across Molise villages.…”

Section: Introductionmentioning

confidence: 99%

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White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Santimone¹,

Castelnuovo²,

Curtis³

et al. 2011

Haematologica

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The online version of this article has a Supplementary Appendix. BackgroundThe understanding of non-genetic regulation of platelet indices -platelet count, plateletcrit, mean platelet volume, and platelet distribution width -is limited. The association of these platelet indices with a number of biochemical, environmental and clinical variables was studied in a large cohort of the general population. Design and MethodsMen and women (n=18,097, 52% women, 56±12 years) were randomly recruited from various villages in Molise (Italy) in the framework of the population-based cohort study "Moli-sani". Hemochromocytometric analyses were performed using an automatic analyzer (Beckman Coulter, IL, Milan, Italy). Associations of platelet indices with dependent variables were investigated by multivariable linear regression analysis. ResultsFull models including age, sex, body mass index, blood pressure, smoking, menopause, white and red blood cell counts, mean corpuscular volume, D-dimers, C-reactive protein, high-density lipoproteins, low-density lipoproteins, triglycerides, glucose, and drug use explained 16%, 21%, 1.9% and 4.7% of platelet count, plateletcrit, mean platelet volume and platelet distribution width variability, respectively; variables that appeared to be most strongly associated were white blood cell count, age, and sex. Platelet count, mean platelet volume and plateletcrit were positively associated with white blood cell count, while platelet distribution width was negatively associated with white blood cell count. Platelet count and plateletcrit were also positively associated with C-reactive protein and D-dimers (P<0.0001). Each of the other variables, although associated with platelet indices in a statistically significant manner, only explained less than 0.5% of their variability. Platelet indices varied across Molise villages, independently of any other platelet count determinant or characteristics of the villages. ConclusionsThe association of platelet indices with white blood cell count, C-reactive protein and Ddimers in a general population underline the relation between platelets and inflammation.Key words: platelet, inflammation, C-reactive protein, white blood cells, age, gender. Citation: Santimone I, Di Castelnuovo A, De Curtis A, Spinelli M, Cugino D, Gianfagna F, Zito F, Donati MB, Cerletti C, de Gaetano G and Iacoviello L on behalf of the Moli-sani ProjectInvestigators.White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project. Haematologica 2011;96(8):1180-1188. doi:10.3324/haematol.2011 This is an open-access paper.White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

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Section: Definition Of Risk Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Santimone¹,

Castelnuovo²,

Curtis³

et al. 2011

Haematologica

Self Cite

154

100

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“…The cohort of the Moli-sani Project (Iacoviello et al, 2007;Centritto et al, 2009) was recruited in the Molise region, Italy, from city hall registries by a multistage sampling. Thirty percent of randomized subjects refused to participate.…”

Section: Study Subjectsmentioning

confidence: 99%

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

et al. 2011

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Background/Objectives: Antioxidant-rich foods may favorably influence lung function. We examined possible associations between the total dietary antioxidant capacity (TAC) and pulmonary function in a healthy Italian population. Subjects/Methods: Until May 2009, 22 300 persons were randomly recruited from the general population in the Moli-sani project. A sample only including healthy women (5824) and men (5848) was analyzed. TAC was measured in foods by three different assays and the ferric reducing-antioxidant power (FRAP) assay was selected as the better indicator of dietary TAC. The European Investigation into Cancer and Nutrition Food Frequency Questionnaire was used for dietary assessment. The association between quintiles of dietary FRAP and pulmonary indexes was assessed using analysis of variance separately for men and women. Results: After adjustment for confounders, women in the highest quintile of FRAP intake had þ 39 ml forced expiratory volume in the first second (FEV 1 ) and þ 54 ml forced vital capacity, compared with those in the lowest quintile (P for trend p0.006). Stratified analysis showed that this relationship only occurred in women who were premenopausal/never smokers. In this subgroup, the observed effect of higher FRAP intake on FEV 1 was equivalent to an improvement in pulmonary age of 3.3 years. In men, all significant associations between pulmonary function and TAC were lost after adjustment for confounding. Conclusions: Dietary TAC may have a favorable role in respiratory health, particularly in premenopausal/never smoker women.

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“…In the SCA plot, hypercholesterolaemia was associated with decreased vegetable intake and a high consumption of meat, cheese and oils. There are numerous studies indicating that the adoption of a diet rich in animal fat and oils and low in vegetables contributes to the development of hyperlipidaemia and increases CVD risk (30) . According to Spence (31) , the actual effect of diet on health is greater than what would be predicted by measuring the effects on fasting lipids, since humans are in a fasting state for only 8 h. Bondia-Pons et al (32) conducted a study for the identification of foods contributing to the dietary profile of Mediterraneans.…”

Section: Discussionmentioning

confidence: 99%

Nutrition transition and health status of Cretan women: evidence from two generations

Tsakiraki

Grammatikopoulou

Stylianou

et al. 2011

Public Health Nutr.

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Objective: Research has suggested the abandonment of the traditional Mediterranean diet (MD) by youngsters for a more Westernized regime. The present study aimed (i) to delineate differences in the consumption of traditional Cretan dishes and key nutrients in the MD between two contiguous generations of women and (ii) define how these dietary changes contribute to the morbidity of the younger generation. Design: Cross-sectional. Setting: The island of Crete, Greece. Subjects: Eighty pairs of mothers and daughters, all living in their own households, were recruited from Crete. Information regarding the consumption of traditional Cretan dishes and two previous-day recalls were collected. The health status of the participants was also recorded. Simple correspondence analysis (SCA) was used to assess associations between differences in the food intake of daughters compared with their mothers and the prevalence of disease. Results: The younger women showed increased intakes of rusks and meat dishes and decreased consumption of green vegetables, pulses and wine compared with their mothers. When nutrients were accounted for, only sugar consumption of the younger women surpassed the intake reported by their mothers. SCA associated hypercholesterolaemia in the daughters with increased cheese and meat intakes; allergies and respiratory problems were associated with lower cheese, fish and oil intakes; being overweight was associated with higher baked goods, oils, desserts, fish and alcohol intakes; and Fe-deficiency anaemia was associated with lower consumption of green vegetables. Conclusions: Results showed that, although a trend towards a more Westernized diet was noted in the younger women, the differences between the two generations appear to be small. Therefore, in Crete, the MD is still the primary diet regime.

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Dietary patterns, cardiovascular risk factors and C-reactive protein in a healthy Italian population

Cited by 142 publications

References 26 publications

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

Nutrition transition and health status of Cretan women: evidence from two generations

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