Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China

Abstract

BackgroundWe investigated whether BCMO1 variants and dietary patterns are associated with lung cancer risk.MethodsCase-control study including 1166 lung cancer cases and 1179 frequency matched controls was conducted for three BCMO1 variants (rs6564851, rs12934922, and rs7501331) and four dietary patterns were investigated. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).ResultsThe rs6564851, rs12934922, and rs7501331 were not found to be associated with lung cancer risk (P > 0.05). In multivariable-adjusted models, compared to the lowest quartile of the score on the “fruits and vegetables” pattern, the highest quintile was associated with a 78.4% decreased risk (OR Q4 vs. Q1 = 0.216; 95% CI, 0.164–0.284; P for trend < 0.001). Other patterns were not found the association. The “fruits and vegetables” pattern was associated with a reduced risk of lung cancer with all 3 SNPs irrespective of genotypes (all P for trend< 0.001). The association for the “Frugal” pattern was associated with increased risk of lung cancer among smokers (P for interaction = 0.005). The protective effects of the “cereals/wheat and meat” pattern was more evident for squamous cell carcinoma and other histological type.ConclusionsWe did not observe associations of BCMO1 variants and lung cancer. Diets rich in fruits and vegetables may be protective against lung cancer.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4361-2) contains supplementary material, which is available to authorized users.

Adherence to Prudent and Mediterranean Dietary Patterns Is Inversely Associated with Lung Cancer in Moderate But Not Heavy Male Polish Smokers: A Case-Control Study

“…This prudent DP included whole grain products, fruits, nuts and seeds, vegetables, fish, legumes, fruits, vegetables, and vegetable-fruit juices, while it was negatively loaded by the consumption frequency of refined grain products, sugar, honey, and sweets. A beneficial effect was previously shown for many pro-healthy dietary patterns, which were rich, similar to the prudent DP, in fruits and vegetables [ 29 ], milk [ 32 ], low-fat foods [ 14 ], fish [ 70 ], pasta, rice, poultry, and oils [ 31 ].…”

“…The research in the world on the relationship between dietary patterns (DPs) and lung cancer, particularly the effects of the Mediterranean diet, is ambiguous and limited. Many studies have investigated the associations between dietary patterns and lung cancer risk [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Though the findings are not definitive, the majority of these studies suggest that a healthy diet is associated with a decreased risk of lung cancer.…”

“…Certainly, the effect is not due to single nutrients, but to a complex of components with synergistic and antagonistic interactions [ 47 ]. However, the evidence is still limited, because there are still only a few studies (including one study of Polish men) focusing on dietary patterns [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] and the Mediterranean diet [ 34 , 44 , 45 , 46 , 47 ] and the risk of lung cancer. To the authors’ knowledge, no studies have so far been published assessing the relationship between dietary patterns and the risk of lung cancer in Polish men who smoked moderately or heavily.…”

Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China

“…This is an ongoing case-control study and the detail of the questionnaire had been published previously [ 17 ]. All epidemiological data were obtained through face-to-face interviews using a standardized questionnaire, which collected information on baseline demographic characteristics, body mass index (BMI), smoking, passive smoking, alcohol consumption, tea drinking, history of lung diseases, family history of cancer, occupational physical activity, physical exercise, cooking oil fume exposure, and pollution near the residence.…”

Relationship between Air Pollution and Lung Cancer in Fujian Province: A Case-control study

“…Occupational physical activity was rated as low, moderate, or high intensity, as de ned by the Reference Standard of Labor Intensity recommended by the Chinese Nutrition Society in 2000. To check for exposure to cooking oil fumes, participants were enquired about whether their degree of exposure to fumes in the kitchen was none (no exposure), light, moderate, or heavy 20 .…”