Dietary patterns and colorectal cancer risk in Zimbabwe: A population based case-control study

Katsidzira, Leolin; Laubscher, Ria; Gangaidzo, Innocent T.; Swart, Rina; Makunike-Mutasa, Rudo; Manyanga, Tadios; Thomson, Sandie; Ramesar, Raj; Matenga, Jonathan; Rusakaniko, Simbarashe

doi:10.1016/j.canep.2018.09.005

Cited by 17 publications

(20 citation statements)

References 22 publications

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“…The high levels in both study groups are consistent with a diet that is predominatly plant based, but significantly lower levels in the urban participants may indicate an initial adaptation of the gut microbiota to dietary changes associated with urban lifestyle. We have previously shown that a traditional African diet, which is predominatly plant based, and associated with rural lifestyle, correlates with lower incidence of CRC in this population (27). We also detected significantly higher levels of Streptococcus bovis et rel.…”

Section: Discussionsupporting

confidence: 58%

Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

Katsidzira

Ocvirk

Wilson

et al. 2019

Nutrition and Cancer

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The incidence of colorectal cancer (CRC) is gradually rising in sub-Saharan Africa.This may be due to dietary changes associated with urbanisation, which may induce tumour-promoting gut microbiota composition and function. We compared faecal microbiota composition and activity in 10 rural and 10 urban Zimbabweans for evidence of a differential CRC risk. Dietary intake was assessed by a food frequency questionnaire. Faecal microbiota composition, metabolomic profile, functional microbial genes were analysed, and bile acids and short chain fatty acids quantified.Animal protein intake was higher among urban volunteers, but carbohydrate and fibre intake were similar. Bacteria related to Blautia obeum, Streptococcus bovis and Subdoligranulum variable were higher in urban residents, whereas bacteria related to Oscillospira guillermondii and Sporobacter termitidis were higher in rural volunteers. Faecal levels of primary bile acids, cholic acid and chenodeoxycholic acid (p<0.05), and secondary bile acids, deoxycholic acid (p<0.05) and ursodeoxycholic acid (p<0.001) were higher in urban residents. Faecal levels of acetate and propionate, but not butyrate, were higher in urban residents. The gut microbiota composition and activity among rural and urban Zimbabweans retain significant homogeneity (possibly due to retention of dietary fibre), but urban residents have subtle changes, which may indicate a higher CRC risk.

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Section: Discussionsupporting

confidence: 58%

Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

Katsidzira

Ocvirk

Wilson

et al. 2019

Nutrition and Cancer

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“…De siete estudios que evaluaron riesgo de cáncer de mama 19,26,27,28,29,30,31 , cuatro encontraron una asociación positiva. Así también, dos de tres estudios que evaluaron cáncer colorrectal encontraron mayor riesgo de cáncer 19,32,33 . Además, tres estudios evaluaron cáncer de próstata 19,34,35 , dos cáncer esofágico 36,37 , uno cáncer de tiroides 38 , uno cáncer hepático 39 , uno cáncer de pulmón 29 , uno leucemia linfocítica crónica 40 , uno cáncer gástrico 41 y uno mortalidad por cáncer 42 .…”

Section: Resultsunclassified

Relación entre consumo de alimentos procesados, ultraprocesados y riesgo de cáncer: una revisión sistemática

Díaz¹,

Glaves

2020

Rev. chil. nutr.

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Este trabajo fue recibido el 02 de abril de 2020. Aceptado con modificaciones: 25 de mayo de 2020. Aceptado para ser publicado: 24 de junio de 2020. RESUMEN La alimentación es un factor de riesgo modificable para el desarrollo de cáncer. El consumo de alimentos procesados y ultraprocesados se ha asociado a mayor riesgo de enfermedades crónicas no transmisibles. El objetivo de esta revisión es evaluar sistemáticamente la evidencia publicada sobre la relación entre el consumo de alimentos procesados y ultraprocesados con el desarrollo de distintos tipos de cáncer. Se realizó una búsqueda sistemática en la base de datos de Pubmed en los últimos 10 años. Se incluyeron estudios de cohorte, caso control o transversales que evaluaran riesgo de cáncer, no recidiva, en adultos y midieron la alimentación a través de encuestas o patrones dietarios. Dos autores revisaron de forma independiente títulos y resúmenes para seleccionar los artículos, posteriormente ambos realizaron una revisión de texto completo, extrajeron los datos y analizaron la calidad metodológica de los estudios incluidos. Los resultados contemplan las conclusiones de 18 estudios, cuatro estudios de cohorte, 13 caso-control y uno transversal. Catorce de los estudios incluidos asocian positivamente la ingesta de alimentos procesados y ultraprocesados con el desarrollo de algunos tipos de cáncer.

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“…In a more global world, the introduction of a Western diet with a high consumption of red processed meet or high glycaemic load carbohydrates with low intake of fruits and vegetables coupled with rising obesity, alcohol consumption and cigarette smoking may result in an increased risk of CRC in low middle income countries to the level seen in high income countries [4,[9][10][11][12]. It is difficult to unravel the relative contributions and interactions of each of these factors to an increased risk of CRC.…”

Section: Possible Reasons Behind the Rise In Incidence Of Crc In Ugandamentioning

confidence: 99%

Perspectives Associated with an Increase in the Incidence of Colorectal Adenocarcinoma in Uganda

Wismayer

2021

JAMMR

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This paper is a current review of work done on colorectal adenocarcinoma in Uganda highlighting the perspectives in the increased rate of cases observed in our hospitals. A steady increase of CRC in other Sub-Saharan African countries is currently being documented however this is associated with a higher CRC-associated morbidity and mortality. Reasons behind this increase may be the nutrition transition in Sub-Saharan Africa characterized by decreased consumption of dietary fibre, starch and plant proteins to a Western diet associated with consumption of fatty foods and red meat. The emergence of noncommunicable diseases such as diabetes and obesity coupled with increased alcohol consumption and smoking confers a higher risk to CRC. A shift in the demographics is observed in Uganda compared to high income countries with 22.8% of our CRC cases being diagnosed at <40years of age compared to 3-7% in high income countries. A challenge experienced with this early age onset is that it is associated with an aggressive biological behavior with a poor prognosis. The high proportion of left sided colon and rectal adenocarcinoma in Uganda makes our population more amenable to screening. However challenges experienced in Uganda and other Sub-Saharan African countries include the availability of endoscopic training and equipment, costs, availability of pathologic services and patient acceptance. The increased diagnosis of CRC cases that will result from screening will eventually require a parallel increase in surgical and oncological infrastructure to manage CRC patients. An improvement in diagnosing, screening and treating CRC by increasing surgical and endoscopic capacity with the aid of international medical and surgical societies should be a public health priority in Uganda given the observed epidemiological shifts. Future implementation of National screening programmes to detect CRC at an early stage is also necessary to reduce the mortality in the Ugandan population.

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Dietary patterns and colorectal cancer risk in Zimbabwe: A population based case-control study

Abstract: HighlightsThree main dietary patterns in Zimbabwe; traditional African, urban and processed foods.Traditional African diet associated with a reduced risk of colorectal cancer.No association between colorectal cancer and the urban or processed food patterns.

Cited by 17 publications

References 22 publications

Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

Relación entre consumo de alimentos procesados, ultraprocesados y riesgo de cáncer: una revisión sistemática

Perspectives Associated with an Increase in the Incidence of Colorectal Adenocarcinoma in Uganda

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