Dietary Patterns After the Weaning and Lactation Period Are Associated With Celiac Disease Autoimmunity in Children

Barroso, Mónica; Beth, Sytske A.; Voortman, Trudy; Jaddoe, Vincent W. V.; Zelm, Menno C. van; Moll, Henriëtte A.; Jong, Jessica C. Kiefte‐de

doi:10.1053/j.gastro.2018.02.024

Cited by 32 publications

(22 citation statements)

References 43 publications

(23 reference statements)

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“…The significance of the overall diet in the risk to develop CD autoimmunity was addressed in the study of Barroso et al in children around the age of 1 year within the Generation R prospective study [35]. After adjustments for potential confounders, a high adherence to a dietary pattern rich in vegetables; vegetable oils; pasta, rice, and other grains and poor in simple sugars, was significantly associated with lower odds of developing CD (OR: 0.67; 95% CI: 0.53-0.84) whereas the consumption of snacks and processed foods was associated with a non-significant increased risk.…”

Section: Additional Dietary Factorsmentioning

confidence: 99%

Coeliac disease: beyond genetic susceptibility and gluten. A narrative review

2019

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Coeliac disease (CD) is an immune-mediated disorder triggered by the ingestion of gluten in genetically susceptible individuals. However, only a small proportion of subjects harbouring CDrelated genetic risk develop the disease. Among the environmental factors that may influence CD risk, pre-and perinatal factors, delivery methods, parental lifestyle, infant feeding practices, seasonality, dietary factors, drug use, childhood infections and variability in gut microbiota are those most widely studied regarding the risk to develop CD. Although for many of these external factors the exact mechanism of action is unknown, most of them are thought to act by disrupting the intestinal barrier, facilitating contact between potential antigens and the immune system effector cells. Management of CD is relatively easy in patients with a definite diagnosis and requires a strict, lifelong, gluten-free diet. Better knowledge of environmental exposures apart from gluten can facilitate understanding of the pathogenesis of the disorder and the wide heterogeneity of its clinical spectrum. The purpose of this review is to discuss current knowledge on environmental CD risk factors, as well as possible interaction between them, on the grounds of the reliable scientific evidence available. KEY MESSAGESThe risk of developing CD is influenced not only by gluten ingestion but also by a number of environmental factors including childhood infections and variability in gut microbiota, preand perinatal factors, infant feeding practices, delivery methods, parental lifestyle, seasonality, dietary factors and drug use, acting mainly by disrupting intestinal permeability. Better knowledge of exposure to these factors can facilitate their identification, and subsequent elimination, in the individual patient.

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Section: Additional Dietary Factorsmentioning

confidence: 99%

Coeliac disease: beyond genetic susceptibility and gluten. A narrative review

2019

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“…Ten studies developed a prediction model for circulating 25 Inflammatory markers 3 1 (19) 0 0 2 (41,42) Insulinaemic markers 1 1 (2) 0 0 0 Vitamin D 10 5 (20)(21)(22)(23)(24) 2 (85,86) 3 (75)(76)(77) 0 Fatty acid 2 0 1 (5) 1 (78) 0 Carotenoids 1 1 (4) 0 0 0 Homocysteine 1 0 0 1 (3) 0 Dioxin and PCB 1 0 0 1 (79) (25)(26)(27) 0 0 (68) 9 (43)(44)(45)(46)(47)(48)(49)(50)(51) Chronic disease-related markers † 32 7 (6,(28)(29)(30)(31)(32)(33) 2 (87,88) 2 (80,81) (69-74) 15 (7,(52)(53)(54)(55)(56)…”

Section: Sex Consideration In Biomarker Prediction Indicesmentioning

confidence: 99%

Sex consideration in diet–biomarker-related indices: a systematic review

Song

Kim

2018

Public Health Nutr.

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“…Our study covered diet in the first half of pregnancy with data collection mid-pregnancy. Dietary patterns around one year of age was a significant predictor for CD in a recent study, with a lower risk in infants with a “prudent” diet consisting of less refined cereals and more fibre 8 .…”

Section: Discussionmentioning

confidence: 96%

“…Speculatively, it seems plausible that fibre intake in the child in early life has a stronger association to CD risk than the maternal fibre intake. Unfortunately, our study contained data on only maternal fibre and the comparable study only on infant fibre 8 , and a direct comparison could not be done.…”

Section: Discussionmentioning

confidence: 99%

“…In the PreventCD trial, gluten intake overall did not predict later CD but was positively associated with CD risk in a subgroup with the HLA-DQ2.5/DQ7 haplotype 7 . A low intake of refined cereals and sweet beverages at age 1 year has been associated with a reduced risk of celiac disease autoimmunity by age six years 8 . This may suggest that not only the individual’s gluten intake but also other dietary factors may modify the risk of disease.…”

Section: Introductionmentioning

confidence: 99%

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Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study

Lund-Blix

Tapia

Mårild

et al. 2020

Sci Rep

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Maternal diet can influence the developing immune system of the offspring. We hypothesized that maternal fibre and gluten intake during pregnancy were associated with the risk of celiac disease in the child. In the Norwegian Mother, Father and Child Cohort Study (MoBa, n = 85,898) higher maternal fibre intake (median 29.5 g/day) was associated with a lower risk of celiac disease in the offspring (adjusted relative risk 0.90, 95% CI 0.83 to 0.98 per 10 g/d increase). Gluten intake during pregnancy (median 13.0 g/d) was associated with a higher risk of childhood CD (adjusted relative risk = 1.21, 95% CI 1.02 to 1.43 per 10 g/d increase). These results were largely unaffected by adjustment for the child’s gluten intake at 18 months. In an independent study of 149 mother/child dyads, maternal fibre intake did not predict concentrations of total or sub-types of short-chain fatty acids in repeated infant stool samples, or fecal microbiome diversity in the mother or child. Our results suggest that high fibre and low gluten intake during pregnancy could be protective factors for celiac disease, although the mechanism is unknown.

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Dietary Patterns After the Weaning and Lactation Period Are Associated With Celiac Disease Autoimmunity in Children

Cited by 32 publications

References 43 publications

Coeliac disease: beyond genetic susceptibility and gluten. A narrative review

Coeliac disease: beyond genetic susceptibility and gluten. A narrative review

Sex consideration in diet–biomarker-related indices: a systematic review

Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study

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