Dietary Oxalate and Calcium Oxalate Nephrolithiasis

Khan, Saeed R.; Glenton, Patricia A.; Byer, Karen J.

doi:10.1016/j.juro.2007.06.046

Cited by 46 publications

(28 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From the above discussion, one can conclude that under normal conditions, crystals do not adhere to renal tubular epithelial cells and are readily excreted in the urine. However, with antecedent renal tubular epithelial damage and during the process of renal tubular repair,144–146 specific crystal-binding proteins are expressed at the apical surface of the renal epithelial cell, predisposing crystal adhesion and possibly stone formation. Whether this process has a pathogenic function in many clinical conditions associated with tubular nephrocalcinosis and nephrolithiasis deserves intense future investigation 130…”

Section: The Role Of Renal Tubular Crystal Retentionmentioning

confidence: 99%

Recent advances in the pathophysiology of nephrolithiasis

Sakhaee

2009

Kidney International

138

View full text Add to dashboard Cite

Over the past 10 years, major progress has been made in the pathogenesis of uric acid and calcium stones. These advances have led to our further understanding of a pathogenetic link between uric acid nephrolithiasis and the metabolic syndrome, the role of Oxalobacter formigenes in calcium oxalate stone formation, oxalate transport in Slc26a6-null mice, the potential pathogenetic role of Randall’s plaque as a precursor for calcium oxalate nephrolithiasis, and the role of renal tubular crystal retention. With these advances, we may target the development of novel drugs including (1) insulin sensitizers; (2) probiotic therapy with O. formigenes, recombinant enzymes, or engineered bacteria; (3) treatments that involve the upregulation of intestinal luminal oxalate secretion by increasing anion transporter activity (Slc26a6), luminally active nonabsorbed agents, or oxalate binders; and (4) drugs that prevent the formation of Randall’s plaque and/or renal tubular crystal adhesions.

show abstract

Section: The Role Of Renal Tubular Crystal Retentionmentioning

confidence: 99%

Recent advances in the pathophysiology of nephrolithiasis

Sakhaee

2009

Kidney International

138

View full text Add to dashboard Cite

show abstract

“…Calcium oxalate is the most common constituent of urinary stones in animal model of the urolithiasis which has been established by means of feeding Hyp, an endogenous precursor of oxalate (Khan et al, 2007). They reported that rats receiving Hyp for 42 days showed hyperoxaluria, calcium oxalate crystalluria and nephrolithiasis.…”

Section: Discussionmentioning

confidence: 99%

Twenty-eight-day oral toxicity study of L-hydroxyproline in rats with 14-day post-treatment observation period

Akiduki¹,

Kawada

Watanabe³

et al. 2019

Fundam. Toxicol. Sci.

View full text Add to dashboard Cite

Repeated-dose oral toxicity of L-hydroxyproline (Hyp) was assessed in male and female SD rats by gavage for 28 days at dose level of 40, 200, 1,000 or 4,000 mg/kg/day. The reversibility of treatment-related changes was also examined by providing 14-day recovery period in the control group and 4,000 mg/kg group. In the results, reduced body weight gain with decreased food consumption was noted in males at 4,000 mg/kg/day. The histopathological evaluation revealed increased incidences of focal dilatation of the renal tubules with narrowing of the tubular cell liner and focal interstitial fibroplasia in the kidney of males at 1,000 and 4,000 mg/kg and females at 4,000 mg/kg. The lack of kidney specific serum chemical or urinalysis findings supported that the renal changes were very mild. Based on the above results, it was concluded that the no observed adverse effect level (NOAEL) of Hyp was 200 mg/kg/day.

show abstract

“…Batas aman konsumsi kalsium oksalat bagi orang dewasa adalah 0.60-1.25 g per hari selama 6 minggu berturut-turut (Khan et al, 2007;Knudsen et al, 2008;Bazin et al, 2016;Bong et al, 2017;Siener et al, 2017;). Untuk itu, perlu dilakukan proses reduksi oksalat pada umbi kimpul agar selanjutnya dapat dikonsumsi tanpa menimbulkan rasa gatal dan juga aman bagi tubuh tanpa memberikan efek negatif terhadap kesehatan.…”

Section: Kadar Kalsium Oksalat Pada Umbi Kimpul Sebelum Dan Setelah Punclassified

Decrease of Oxalate on Construction Process of New Cocoyam (Xanthosoma Sagittifolium) in Various Consentration of Acetic Acid

Agustin

Estiasih²,

Krisna³

2017

JTP

View full text Add to dashboard Cite

ABSTRAKReduksi oksalat pada tanaman umbi-umbian sangat diperlukan terutama senyawa oksalat pada umbi kimpul yang seringkali menyebabkan rasa gatal pada rongga mulut dan tenggorokan saat dikonsumsi. Reduksi oksalat metode kimiawi yang sering digunakan adalah menggunakan asam kuat (HCl). Asam oksalat bersifat larut dalam air, sementara kalsium oksalat tidak larut dalam air tetapi larut dalam asam kuat. Penggunaan HCl menimbulkan rasa dan bau asam yang sangat kuat, sehingga diperlukan metode lain yaitu dengan menggunakan golongan asam lemah yang aman untuk dikonsumsi lebih lanjut, yaitu asam asetat. Tujuan penelitian ini adalah untuk mengetahui proporsi terbaik dalam menurunkan kadar kalsium oksalat pada umbi kimpul segar. Penelitian ini menggunakan rancangan percobaan Rancangan Acak Kelompok (RAK) faktorial yang terdiri dari 2 faktor, faktor I adalah konsentrasi asam asetat dalam 3 level (10%, 15%, dan 20%), serta faktor II adalah lama perendaman dalam 3 level (10 menit, 20 menit, dan 30 menit). Hasil penelitian menunjukkan bahwa perlakuan asam asetat dan lama perendaman dapat menurunkan kadar total oksalat pada umbi kimpul segar. Kadar total oksalat setelah perlakuan perendaman larutan asam asetat dapat menurunkan kadar total oksalat hingga 66% yaitu sebesar 443 mg/100 g. Hal ini didukung dengan hasil analisa karakteristik umbi kimpul yang diperoleh yaitu kadar air 59.51%, kadar abu 1.36%, kadar lemak 0.19%, kadar protein 2.28%, kadar karbohidrat 35.66%, kadar oksalat 1.313 mg/100 g, dan komposisi unsur kalsium oksalat pada umbi kimpul dengan perlakuan perendaman larutan asam asetat pada C sebesar 48.30%, O sebesar 49.59%, Ca sebesar 01.45%. Hasil analisa SEM didapatkan kalsium oksalat berbentuk jarum (raphide) dengan ukuran 3.944-11.47 μm ABSTRACT Oxalate reduction in tuber crops is necessary, especially oxalic compounds which cause itching in the oral cavity and throat. To reduce the oxalate, the commonly used method is chemical using strong acid (HCl). Oxalic acid is soluble in water, while calcium oxalate is insoluble in water, but dissolves in strong acids. The application of HCl cause a strong taste and smell of acids, so it takes other method in by using acetic acid. The purpose of this study was to determine the best proportion in decreasing calcium oxalate levels in cocoyam tubers. This study used a factorial Randomized Block Design (RBD) design consisting of 2 factors, factor I, was acetic acid concentration in 3 levels (10%, 15%, and 20%) and factor II, was soaking duration in 3 levels (10 minutes, 20 minutes, and 30 minutes). The results showed that the treatment of acetic acid and soaking time decrease the oxalate content in cocoyam tubers. Calcium oxalate level after treatment of soaking acetic acid solution decrease the calcium oxalate level up to 66% that is equal to 443 mg/100 g. Supported result of characteristic analysis of cocoyam tuber obtained such as water content 59.51%, ash content 1.36%, fat content 0.19%, protein content 2.28%, carbohydrate 35.66%, and calcium oxalate 1.313 mg/100 g, an...

show abstract

Dietary Oxalate and Calcium Oxalate Nephrolithiasis

Cited by 46 publications

References 20 publications

Recent advances in the pathophysiology of nephrolithiasis

Recent advances in the pathophysiology of nephrolithiasis

Twenty-eight-day oral toxicity study of L-hydroxyproline in rats with 14-day post-treatment observation period

Decrease of Oxalate on Construction Process of New Cocoyam (Xanthosoma Sagittifolium) in Various Consentration of Acetic Acid

Contact Info

Product

Resources

About