Dietary overload lithium decreases the adipogenesis in abdominal adipose tissue of broiler chickens

Bai, Shiping; Pan, Shuqin; Zhang, Keying; Ding, Xuemei; Wang, Jianping; Zeng, Qiufeng; Xuan, Yue; Su, Zuowei

doi:10.1016/j.etap.2016.12.012

Cited by 8 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High-dose lithium treatment to chicks decreased abdominal adipose tissue after 35 but not 14 days. (Bai et al 2017) Our results are congruent with these findings that is, a 14 day regimen of lithium feeding did not alter fat mass. However, a significant reduction in fat mass, together with increased multilocular lipid droplet morphology, high mitochondrial content, and mRNA and protein expression of UCP1 in adipocytes, was observed in mice that consumed lithium for 14 days concurrent with sPRR-His administration for the final 7 days.…”

Section: Discussionsupporting

confidence: 90%

The soluble (Pro) renin receptor does not influence lithium‐induced diabetes insipidus but does provoke beiging of white adipose tissue in mice

Yang

Wang

et al. 2017

Physiological Reports

View full text Add to dashboard Cite

Earlier we reported that the recombinant soluble (pro) renin receptor sPRR‐His upregulates renal aquoporin‐2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy develop polyuria associated NDI that might be secondary to downregulation of renal AQP2. We hypothesized that sPRR‐His attenuates indices of NDI associated with lithium treatment. Eight‐week‐old male C57/BL6 mice consumed chow supplemented with LiCl (40 mmol/kg diets) for 14 days. For the last 7 days mice received either sPRR‐His [30 μg/(kg day), i.v.; sPRR] or vehicle (Veh) via minipump. Control (Con) mice consumed standard chow for 14 days. Compared to Con mice, 14‐d LiCl treatment elevated water intake and urine volume, and decreased urine osmolality, regardless of sPRR‐His or Veh administration. These data indicate that sPRR‐His treatment does not attenuate indices of NDI evoked by lithium. Unexpectedly, epididymal fat mass was lower, adipocyte UCP1 mRNA and protein expression were higher, and multilocular lipid morphology was enhanced, in LiCl‐fed mice treated with sPRR‐His versus vehicle. The beiging of white adipose tissue is a novel metabolic benefit of manipulating the sPRR in the context of lithium‐induced NDI.

show abstract

Section: Discussionsupporting

confidence: 90%

The soluble (Pro) renin receptor does not influence lithium‐induced diabetes insipidus but does provoke beiging of white adipose tissue in mice

Yang

Wang

et al. 2017

Physiological Reports

View full text Add to dashboard Cite

show abstract

“…Overall, adipogenesis in chicken comprises three different stages, including adipocyte proliferation, adipocyte differentiation, and lipid accumulation inside mature adipocytes. In which, several transcription factors, adipogenic-related genes, and miRNAs can regulate these three different stages through adipogenesis [40] (Figure 2). For instance, both transcription factors, including PPARγ, which participates in induction and stimulation of fat-specific genes and fatty acid synthesis, and PPARβ/δ, which participates in stimulation of fatty acid oxidation, are necessary to provide maximum lipid accumulation and differentiation during adipogenesis [35].…”

Section: Adipogenesis In Chickenmentioning

confidence: 99%

Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken

Nematbakhsh

Chong

Selamat

et al. 2021

Genes

View full text Add to dashboard Cite

In the poultry industry, excessive fat deposition is considered an undesirable factor, affecting feed efficiency, meat production cost, meat quality, and consumer’s health. Efforts to reduce fat deposition in economically important animals, such as chicken, can be made through different strategies; including genetic selection, feeding strategies, housing, and environmental strategies, as well as hormone supplementation. Recent investigations at the molecular level have revealed the significant role of the transcriptional and post-transcriptional regulatory networks and their interaction on modulating fat metabolism in chickens. At the transcriptional level, different transcription factors are known to regulate the expression of lipogenic and adipogenic genes through various signaling pathways, affecting chicken fat metabolism. Alternatively, at the post-transcriptional level, the regulatory mechanism of microRNAs (miRNAs) on lipid metabolism and deposition has added a promising dimension to understand the structural and functional regulatory mechanism of lipid metabolism in chicken. Therefore, this review focuses on the progress made in unraveling the molecular function of genes, transcription factors, and more notably significant miRNAs responsible for regulating adipogenesis, lipogenesis, and fat deposition in chicken. Moreover, a better understanding of the molecular regulation of lipid metabolism will give researchers novel insights to use functional molecular markers, such as miRNAs, for selection against excessive fat deposition to improve chicken production efficiency and meat quality.

show abstract

“…Dietary Ile supplementation markedly decreased lipid deposition in the abdomen as reported in a previous study of broilers ( Maynard et al, 2022 ). The formation of adipose tissue includes the differentiation of preadipocytes to adipocytes and the proliferation of adipocytes ( Bai et al, 2017 ). The PPARγ and C/EBPα are the main regulators of preadipocyte differentiation, while KI67, TOP2A , and TPX2 are markers of adipocyte proliferation.…”

Section: Discussionmentioning

confidence: 99%

Low-protein diets supplemented with isoleucine alleviate lipid deposition in broilers through activating 5′ adenosine monophosphate-activated protein kinase and janus kinase 2/signal transducer and activator of transcription 3 signaling pathways

Ma¹,

Zhang²,

Shi³

et al. 2023

Poultry Science

View full text Add to dashboard Cite

Dietary overload lithium decreases the adipogenesis in abdominal adipose tissue of broiler chickens

Cited by 8 publications

References 40 publications

The soluble (Pro) renin receptor does not influence lithium‐induced diabetes insipidus but does provoke beiging of white adipose tissue in mice

The soluble (Pro) renin receptor does not influence lithium‐induced diabetes insipidus but does provoke beiging of white adipose tissue in mice

Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken

Low-protein diets supplemented with isoleucine alleviate lipid deposition in broilers through activating 5′ adenosine monophosphate-activated protein kinase and janus kinase 2/signal transducer and activator of transcription 3 signaling pathways

Contact Info

Product

Resources

About