Abstract:While diet and nutrition are modifiable risk factors for many chronic and infectious diseases, their role in cancer prevention and control remains under investigation. The lack of clarity of some diet–cancer relationships reflects the ongoing debate about the relative contribution of genetic factors, environmental exposures, and replicative errors in stem cell division as determinate drivers of cancer risk. In addition, dietary guidance has often been based upon research assuming that the effects of diet and n… Show more
“…After all, recent studies suggest the use of drugs that act on orexinergic receptors also in the treatment of different cancers including colon, pancreas and prostate cancers [54] and neurodegenerative diseases [55,56] such as Alzheimer's disease (AD) where orexinergic system dysregulation promotes sleep-wake cycle impairment [57] and also interacts with CSF AD biomarkers, such as beta-amyloid and tau proteins. Along this line, the role of nutrition in sleep medicine [58] and secondary prevention strategies is continuously increasing both in oncology and neurodegeneration [59,60].…”
Section: The Relationship Between Orexin Rem Sleep and Appetitementioning
Orexin plays a significant role in the modulation of REM sleep, as well as in the regulation of appetite and feeding. This review explores, first, the current evidence on the role of orexin in the modulation of sleep and wakefulness and highlights that orexin should be considered essentially as a neurotransmitter inhibiting REM sleep and, to a much lesser extent, a wake promoting agent. Subsequently, the relationship between orexin, REM sleep, and appetite regulation is examined in detail, shedding light on their interconnected nature in both physiological conditions and diseases (such as narcolepsy, sleep-related eating disorder, idiopathic hypersomnia, and night eating syndrome). Understanding the intricate relationship between orexin, REM sleep, and appetite regulation is vital for unraveling the complex mechanisms underlying sleep-wake patterns and metabolic control. Further research in this field is encouraged in order to pave the way for novel therapeutic approaches to sleep disorders and metabolic conditions associated with orexin dysregulation.
“…After all, recent studies suggest the use of drugs that act on orexinergic receptors also in the treatment of different cancers including colon, pancreas and prostate cancers [54] and neurodegenerative diseases [55,56] such as Alzheimer's disease (AD) where orexinergic system dysregulation promotes sleep-wake cycle impairment [57] and also interacts with CSF AD biomarkers, such as beta-amyloid and tau proteins. Along this line, the role of nutrition in sleep medicine [58] and secondary prevention strategies is continuously increasing both in oncology and neurodegeneration [59,60].…”
Section: The Relationship Between Orexin Rem Sleep and Appetitementioning
Orexin plays a significant role in the modulation of REM sleep, as well as in the regulation of appetite and feeding. This review explores, first, the current evidence on the role of orexin in the modulation of sleep and wakefulness and highlights that orexin should be considered essentially as a neurotransmitter inhibiting REM sleep and, to a much lesser extent, a wake promoting agent. Subsequently, the relationship between orexin, REM sleep, and appetite regulation is examined in detail, shedding light on their interconnected nature in both physiological conditions and diseases (such as narcolepsy, sleep-related eating disorder, idiopathic hypersomnia, and night eating syndrome). Understanding the intricate relationship between orexin, REM sleep, and appetite regulation is vital for unraveling the complex mechanisms underlying sleep-wake patterns and metabolic control. Further research in this field is encouraged in order to pave the way for novel therapeutic approaches to sleep disorders and metabolic conditions associated with orexin dysregulation.
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