Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice

Abstract

Olacein (OLA), one of the main secoiridoids derived from extra virgin olive oil (EVOO), has been shown to modulate oxidative and inflammatory responses in various pathological conditions; however, its potential...

Oxidative Stress as a Target for Non-Pharmacological Intervention in MAFLD: Could There Be a Role for EVOO?

“…Several studies have focused on EVOO and its compounds, showing beneficial effects on body weight (quantitative reduction) [ 112 ], adipose tissue (quantitative reduction and positive metabolic modulation) [ 113 , 114 ], lipidic ratio (reduction of total cholesterol (TC), TC/high-density lipoproteins (HDL), and low-density lipoprotein (LDL) oxidation; increase of HDL concentrations) [ 115 , 116 ], glycemic metabolism (reduction of T2DM incidence, fasting glucose, and advanced glycosylated end-products, including glycated hemoglobin; activation of the glucagon-like peptide-1 (GLP-1) incretin-pattern) [ 117 , 118 , 119 , 120 ], and cardiovascular risk (reduction of LDL oxidation, systolic blood pressure, and cardiovascular events, improvement of nitric oxide (NO)-mediated endothelial function) [ 121 , 122 , 123 , 124 ]. To a further extent, but with a lesser degree of evidence (mostly preclinical studies), EVOO intake showed effectiveness in the reduction/modulation of autoimmune [ 125 , 126 , 127 , 128 , 129 ], inflammatory bowel [ 130 , 131 , 132 , 133 ], neurodegenerative [ 134 , 135 , 136 , 137 , 138 ], and neoplastic diseases [ 137 , 139 , 140 ], as well as gut microbiota alterations [ 141 , 142 , 143 , 144 ].…”