Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

Wu, Jianmin; Zhao, Ying; Wang, Xian; Kong, Lingchang; Johnston, Lee J; Lin, Lu; Ma, Xi

doi:10.1080/10408398.2020.1828813

Cited by 73 publications

(40 citation statements)

References 128 publications

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“…Gut microbiota can cause heritable phenotypic changes through epigenetic modification of host genome (Stilling et al 2014; Krautkramer et al 2016; Grieneisen et al 2020). DNA methylation is an epigenetic mechanism known to play a critical role in re-establishing gut homeostasis in intestinal tissue (Ansari et al 2020; Wu et al 2020), suggesting this may be a bi-directional relationship. The observed changes in some phenotypic traits (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…food resources) could alter host DNA methylation, leading to beneficial phenotypic changes that increase host fitness (Stilling et al 2014; Krautkramer et al 2016; Grieneisen et al 2020). Second, environmental factors could alter host DNA methylation, which could affect the host’s ability to use local microbes or to maintain a balanced gut bacteria by supressing nonbeneficial microbes (Ansari et al 2020; Wu et al 2020). Future studies including, fecal transplantation and methylation manipulation experiments will be needed to illuminate the causal relationship and underlying mechanisms in this system.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, gut microbiota guides and/or facilitates epigenetic development of intestinal stem cells during the postnatal period and may influence lifelong gut health (Yu et al 2015). At the same time, host epigenetic status may affect gut microbiota: DNA methylation in intestinal tissue is known to contribute to the regulation of genes involved in cell proliferation, anti-bacteria metabolite production, anti-inflammation and to play a critical role in re-establishing gut homeostasis in mice (Ansari et al 2020; Wu et al 2020). These results suggest that it is important to examine the interaction between gut bacteria and host DNA methylation, and that this relationship can be bi-directional.…”

Section: Introductionmentioning

confidence: 99%

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Genetic similarity enhances the strength of the relationship between gut bacteria and host DNA methylation

Zhou

Tesfamicael²,

Sj³

et al. 2021

Preprint

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Factors such as host age, sex, diet, health status and genotype constitute the environmental envelope shaping microbial communities in the host’s gut. It has also been proposed that gut microbiota may be influenced by host epigenetics. Although the relationship between the host’s genotype/epigenotype and its associated microbiota has been the focus of a number of recent studies, the relative importance of these interactions and their biological relevance are still poorly understood. We used methylation-sensitive genotyping by sequencing to genotype and epigenotype invasive cane toads (Rhinella marina) from the species’ Australian range-core (three sites) and the invasion-front (three sites), and 16S rRNA gene sequencing to characterize their gut bacterial communities. We tested the effect of host genotype and epigenotype (i.e., methylome) on gut bacterial communities. Our results indicate that the genotypes, epigenotypes and gut communities of the range-core and invasion-front are significantly different from one another. We found a positive association between host pairwise genetic and epigenetic distances. More importantly, a positive relationship was found between the host’s epigenetic and gut bacterial pairwise distances. Interestingly, this association was stronger in individuals with low genetic differentiation. Our findings suggest that in range-expanding populations, where individuals are often genetically similar, the interaction between gut bacterial communities and host methylome may provide a mechanism through which invaders increase the plasticity of their response to novel environments, potentially increasing their invasion success.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic similarity enhances the strength of the relationship between gut bacteria and host DNA methylation

Zhou

Tesfamicael²,

Sj³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Lactobacillus and Bifidobacterium species in the intestinal symbiotic flora can synthesize folic acid to increase DNA methylation and mRNA m6A modification in the intestinal tract, thus ensuring the normal development of the intestinal tract. 72 Similarly, Jabs et al found that the intestinal microbiota affects the epithelial transcriptome of m6A in the cecum of mice. Changes in intestinal microbiota are associated with m6A modification in the cecum and to a lesser extent, affect m6A modification in the liver, affecting pathways related to metabolism, inflammation, and antimicrobial responses.…”

Section: Regulation Of Intestinal Mucosal Immunity By M6a Rna Modificationmentioning

confidence: 94%

The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer

Xu¹,

Huang²,

Ocansey³

et al. 2021

JIR

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Methylation, first proposed in DNAs, but later found in RNAs, serves as one of the most widespread epigenetic modifications in eukaryotes, where N6-methyladenosine (m6A) modification has been found to play an important role in a variety of cancers including colorectal cancer (CRC). Under the action of various enzymes and proteins, the regulatory role of m6A in RNAs and immune cells has also been gradually realized. This paper reviews the general biogenesis and effects of m6A, and its emerging crucial role in intestinal mucosal immunity via the regulation of RNAs and immune cells, and thus closely related to the occurrence and development of inflammatory bowel disease (IBD) and CRC. m6A-related genes and regulatory factors are expected to be potential predictive markers and therapeutic targets.

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“…The GM enhances the expression of the VDR in intestinal epithelial cells. Products such as short chain fatty acids (SCFA), specifically butyrate, enhance cathelicidin formation in colonocytes that are regulated by vitD [96][97][98]. The human cathelicidin gene (CAMP) encodes for a specific antimicrobial peptide LL-37 in coloncytes, and activation of this cathelicidin is vitD-mediated [99,100].…”

Section: Mediators Of Inflammationmentioning

confidence: 99%

Immunometabolism, Micronutrients, and Bariatric Surgery: The Use of Transcriptomics and Microbiota-Targeted Therapies

Galyean

Sawant

Shin

2020

Mediators of Inflammation

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Background. Obesity is associated with the gut microbiota and decreased micronutrient status. Bariatric surgery is a recommended therapy for obesity. It can positively affect the composition of the gut bacteria but also disrupt absorption of nutrients. Low levels of micronutrients can affect metabolic processes, like glycolysis, TCA cycle, and oxidative phosphorylation, that are associated with the immune system also known as immunometabolism. Methods. MEDLINE, PUBMED, and Google Scholar were searched. Articles involving gut microbiome, micronutrient deficiency, gut-targeted therapies, transcriptome analysis, micronutrient supplementation, and bariatric surgery were included. Results. Studies show that micronutrients play a pivotal role in the intestinal immune system and regulating immunometabolism. Research demonstrates that gut-targeting therapies may improve the microbiome health for bariatric surgery populations. There is limited research that examines the role of micronutrients in modulating the gut microbiota among the bariatric surgery population. Conclusions. Investigations are needed to understand the influence that micronutrient deficiencies have on the gut, particularly immunometabolism. Nutritional transcriptomics shows great potential in providing this type of analysis to develop gut-modulating therapies as well as more personalized nutrition recommendations for bariatric surgery patients.

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Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

Cited by 73 publications

References 128 publications

Genetic similarity enhances the strength of the relationship between gut bacteria and host DNA methylation

Genetic similarity enhances the strength of the relationship between gut bacteria and host DNA methylation

The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer

Immunometabolism, Micronutrients, and Bariatric Surgery: The Use of Transcriptomics and Microbiota-Targeted Therapies

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